Search Results - "Kondo, Naoya"

A Red-Emitting Fluorescence Sensor for Detecting Boronic Acid-Containing Agents in Cells by Kondo, Naoya, Aoki, Erika, Takada, Shinya, Temma, Takashi

“…The amount and localization of boron-10 atoms delivered into tumor cells determines the therapeutic effect of boron neutron capture therapy (BNCT) and,…”
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Development of a switching-type fluorescence sensor for the detection of boronic acid-containing agents by Takada, Shinya, Kondo, Naoya, Hagimori, Masayori, Temma, Takashi

“…Since the therapeutic effect of boron neutron capture therapy is influenced by the intracellular distribution profile of boronoagents containing 10 B atoms, it…”
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Evaluation of 3-Borono-l-Phenylalanine as a Water-Soluble Boron Neutron Capture Therapy Agent by Kondo, Naoya, Hirano, Fuko, Temma, Takashi

“…Although 4-borono-l-phenylalanine (4-BPA) is currently the only marketed agent available for boron neutron capture therapy (BNCT), its low water solubility…”
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Development of a 2-(2-Hydroxyphenyl)-1H-benzimidazole-Based Fluorescence Sensor Targeting Boronic Acids for Versatile Application in Boron Neutron Capture Therapy by Kondo, Naoya, Takada, Shinya, Hagimori, Masayori, Temma, Takashi

“…Boron neutron capture therapy (BNCT) is an attractive approach to treating cancers. Currently, only one 10B-labeled boronoagent (Borofalan, BPA) has been…”
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Development of radioiodinated pyrimidinopyridone derivatives as targeted imaging probes of activated p38α for single photon emission computed tomography by Hashimoto, Tomoyuki, Kondo, Naoya, Hirata, Masahiko, Temma, Takashi

“…Objective p38α, a member of the mitogen-activated protein kinase superfamily, is ubiquitously expressed in a variety of mammalian cells. Activated p38α induces…”
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Indirectly radioiodinated exendin-4 as an analytical tool for in vivo detection of glucagon-like peptide-1 receptor in a disease setting by Kondo, Naoya, Oishi, Ayaka, Hirata, Masahiko, Temma, Takashi

“…Objective Glucagon-like peptide-1 receptor agonist (GLP-1RA) has been reported to have therapeutic effects on diabetes and various diseases. Precise detection…”
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Radiobrominated probe targeting activated p38α in inflammatory diseases by Hashimoto, Tomoyuki, Kondo, Naoya, Makino, Akira, Kiyono, Yasushi, Temma, Takashi

“…Objective p38α, a member of the mitogen-activated protein kinase superfamily, is activated by external stimuli, followed by nuclear translocation for the…”
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A report of three cases of patients with tubulointerstitial nephritis with IgM-positive plasma cells, treatment, and serum-IgM as a sensitive marker for relapse by Akagi, Ryota, Ishii, Akira, Kaneko, Keiichi, Kondo, Naoya, Yokoi, Hideki, Matsubara, Takeshi, Minamiguchi, Sachiko, Kanno, Yoshihiko, Yanagita, Motoko

“…Tubulointerstitial nephritis with IgM-positive plasma cells (IgMPC-TIN) is a newer disease about which there are many unclear points. Glucocorticoid therapy is…”
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Hypertrophic pachymeningitis in ANCA-associated vasculitis: a cross-sectional and multi-institutional study in Japan (J-CANVAS) by Shimojima, Yasuhiro, Kishida, Dai, Ichikawa, Takanori, Kida, Takashi, Yajima, Nobuyuki, Omura, Satoshi, Nakagomi, Daiki, Abe, Yoshiyuki, Kadoya, Masatoshi, Takizawa, Naoho, Nomura, Atsushi, Kukida, Yuji, Kondo, Naoya, Yamano, Yasuhiko, Yanagida, Takuya, Endo, Koji, Hirata, Shintaro, Matsui, Kiyoshi, Takeuchi, Tohru, Ichinose, Kunihiro, Kato, Masaru, Yanai, Ryo, Matsuo, Yusuke, Nishioka, Ryo, Okazaki, Ryota, Takata, Tomoaki, Ito, Takafumi, Moriyama, Mayuko, Takatani, Ayuko, Miyawaki, Yoshia, Ito-Ihara, Toshiko, Kawaguchi, Takashi, Kawahito, Yutaka, Sekijima, Yoshiki

“…Abstract Background This study investigated the characteristics of hypertrophic pachymeningitis (HP) in antineutrophil cytoplasmic antibody (ANCA)-associated…”
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Radioiodinated Peptidic Imaging Probes for in Vivo Detection of Membrane Type-1 Matrix Metalloproteinase in Cancers by Kondo, Naoya, Temma, Takashi, Shimizu, Yoichi, Ono, Masahiro, Saji, Hideo

“…Membrane type-1 matrix metalloproteinase (MT1-MMP) plays pivotal roles in tumor progression and metastasis, and holds great promise as an early biomarker for…”
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Synthesis and evaluation of [18F]FBNAF, a STAT3-targeting probe, for PET imaging of tumor microenvironment by Miyazaki, Anna, Kanai, Yasukazu, Wakamori, Keita, Mizuguchi, Serina, Futatsugi, Mikiya, Hirano, Fuko, Kondo, Naoya, Temma, Takashi

“…Background Signal transducer and activator of transcription 3 (STAT3) is a protein that regulates cell proliferation and differentiation, and it is attracting…”
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疾患におけるマトリックスメタロプロテアーゼ発現のインビボ定量法構築を目的とした核医学イメージングプローブの開発 by 近藤, 直哉

“…「1. はじめに」マトリックスメタロプロテアーゼ(matrix metalloproteinase; MMP)は主に細胞外マトリックス分解に関与する酵素であり, 種々の炎症性疾患において, その発現・活性の重症度との相関性や, 治療標的としての有効性が数多く報告されている. したがって,…”
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Acetaminophen administration and the risk of acute kidney injury: a self-controlled case series study by Hiragi, Shusuke, Yamada, Hiroyuki, Tsukamoto, Tatsuo, Yoshida, Kazuki, Kondo, Naoya, Matsubara, Takeshi, Yanagita, Motoko, Tamura, Hiroshi, Kuroda, Tomohiro

“…Acetaminophen (APAP) is frequently used for analgesia and is considered safer than nonsteroidal anti-inflammatory drugs (NSAIDs) for the kidneys. However,…”
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Miniaturized antibodies for imaging membrane type‐1 matrix metalloproteinase in cancers by Kondo, Naoya, Temma, Takashi, Shimizu, Yoichi, Watanabe, Hiroyuki, Higano, Keiichi, Takagi, Yoko, Ono, Masahiro, Saji, Hideo

“…Since membrane type‐1 matrix metalloproteinase (MT1‐MMP) plays pivotal roles in tumor progression and metastasis and holds great promise as an early biomarker…”
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Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models by Ameku, Tomonaga, Taura, Daisuke, Sone, Masakatsu, Numata, Tomohiro, Nakamura, Masahiro, Shiota, Fumihiko, Toyoda, Taro, Matsui, Satoshi, Araoka, Toshikazu, Yasuno, Tetsuhiko, Mae, Shin-Ichi, Kobayashi, Hatasu, Kondo, Naoya, Kitaoka, Fumiyo, Amano, Naoki, Arai, Sayaka, Ichisaka, Tomoko, Matsuura, Norio, Inoue, Sumiko, Yamamoto, Takuya, Takahashi, Kazutoshi, Asaka, Isao, Yamada, Yasuhiro, Ubara, Yoshifumi, Muso, Eri, Fukatsu, Atsushi, Watanabe, Akira, Sato, Yasunori, Nakahata, Tatsutoshi, Mori, Yasuo, Koizumi, Akio, Nakao, Kazuwa, Yamanaka, Shinya, Osafune, Kenji

“…Cardiovascular complications are the leading cause of death in autosomal dominant polycystic kidney disease (ADPKD), and intracranial aneurysm (ICA) causing…”
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Monoclonal gammopathy of renal significance (MGRS)-related AL amyloidosis complicated by amyloid myopathy: a case report by Ono, Erina, Ishii, Akira, Higashi, Yoshiaki, Koita, Natsuko, Ayaki, Takashi, Tanigaki, Katsuya, Takayanagi, Shunsuke, Kondo, Naoya, Sakai, Kaoru, Endo, Shuichiro, Yokoi, Hideki, Matsubara, Takeshi, Minamiguchi, Sachiko, Nishino, Ichizo, Takahashi, Ryosuke, Yanagita, Motoko

“…Lately, monoclonal gammopathy of renal significance (MGRS) has been defined as a group of renal disorders that are strongly associated with monoclonal protein,…”
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Investigation of a MMP-2 activity-dependent anchoring probe for nuclear imaging of cancer by Temma, Takashi, Hanaoka, Hirofumi, Yonezawa, Aki, Kondo, Naoya, Sano, Kohei, Sakamoto, Takeharu, Seiki, Motoharu, Ono, Masahiro, Saji, Hideo

“…Since matrix metalloproteinase-2 (MMP-2) is an important marker of tumor malignancy, we developed an original drug design strategy, MMP-2 activity dependent…”
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Long-term survival and renal dysfunction in a patient with recurrent colorectal cancer treated with Bevacizumab by Kataoka, Shigeki, Nishikawa, Yoshitaka, Funakoshi, Taro, Horimatsu, Takahiro, Kondo, Naoya, Matsubara, Takeshi, Yanagita, Motoko, Matsumoto, Shigemi, Muto, Manabu

“…Advances in cancer chemotherapy have increased the opportunities of treating patients with cancer with renal dysfunction. Here we report the case of a…”
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Comparison of 125I- and 111In-labeled peptide probes for in vivo detection of oxidized low-density lipoprotein in atherosclerotic plaques by Temma, Takashi, Kondo, Naoya, Yoda, Keiko, Nishigori, Kantaro, Onoe, Satoru, Shiomi, Masashi, Ono, Masahiro, Saji, Hideo

“…Objective Oxidized low-density lipoprotein (OxLDL) plays a pivotal role in atherosclerotic plaque destabilization, which suggests its potential as a nuclear…”
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In vivo imaging of membrane type‐1 matrix metalloproteinase with a novel activatable near‐infrared fluorescence probe by Shimizu, Yoichi, Temma, Takashi, Hara, Isao, Makino, Akira, Kondo, Naoya, Ozeki, Ei‐ichi, Ono, Masahiro, Saji, Hideo

“…Membrane type‐1 matrix metalloproteinase (MT1‐MMP) is a protease activating MMP‐2 that mediates cleavage of extracellular matrix components and plays pivotal…”
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