Search Results - "Kondej, Magda"

Current Concepts and Treatments of Schizophrenia by Stępnicki, Piotr, Kondej, Magda, Kaczor, Agnieszka A

“…Schizophrenia is a debilitating mental illness which involves three groups of symptoms, i.e., positive, negative and cognitive, and has major public health…”
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Multi-Target Approach for Drug Discovery against Schizophrenia by Kondej, Magda, Stępnicki, Piotr, Kaczor, Agnieszka A

“…Polypharmacology is nowadays considered an increasingly crucial aspect in discovering new drugs as a number of original single-target drugs have been…”
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Synthesis, Structural and Thermal Studies of 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1H-indole (D2AAK1_3) as Dopamine D2 Receptor Ligand by Kondej, Magda, Bartyzel, Agata, Pitucha, Monika, Wróbel, Tomasz, Silva, Andrea, Matosiuk, Dariusz, Castro, Marián, Kaczor, Agnieszka

“…Compound D2AAK1_3 was designed as a modification of the lead structure D2AAK1 (an in vivo active multi-target compound with nanomolar affinity to a number of…”
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The Antipsychotic D2AAK1 as a Memory Enhancer for Treatment of Mental and Neurodegenerative Diseases by Koszła, Oliwia, Sołek, Przemysław, Woźniak, Sylwia, Kędzierska, Ewa, Wróbel, Tomasz M, Kondej, Magda, Archała, Aneta, Stępnicki, Piotr, Biała, Grażyna, Matosiuk, Dariusz, Kaczor, Agnieszka A

“…The treatment of memory impairments associated with the central nervous system diseases remains an unmet medical need with social and economic implications…”
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N -(2-Hydroxyphenyl)-1-[3-(2-oxo-2,3-dihydro-1 H - benzimidazol-1-yl)propyl]piperidine-4-Carboxamide (D2AAK4), a Multi-Target Ligand of Aminergic GPCRs, as a Potential Antipsychotic by Kaczor, Agnieszka A, Targowska-Duda, Katarzyna M, Silva, Andrea G, Kondej, Magda, Biała, Grażyna, Castro, Marián

“…-(2-hydroxyphenyl)-1-[3-(2-oxo-2,3-dihydro-1 -benzimidazol -1-yl)propyl]piperidine-4-carboxamide (D2AAK4) is a multitarget ligand of aminergic G…”
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Development and validation of the HPLC method for varenicline determination in pharmaceutical preparation by Pietras, Rafal, Szymanska, Katarzyna, Kondej, Magda, Gladysz, Agata, Kowalczuk, Dorota

“…A simple and accurate reverse phase HPLC method has been developed and validated for quantification of varenicline in bulk drug and pharmaceutical dosage…”
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Experimental and computational structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles by Bartyzel, Agata, Kondej, Magda, Stępnicki, Piotr, Wróbel, Tomasz M., Kaczor, Agnieszka A.

“…•Four D2, 5-HT1A and 5-HT2A ligands were subjected to structural characterization.•Crystal structures were determined with single crystal X-ray…”
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Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs by Kondej, Magda, Wróbel, Tomasz M., Silva, Andrea G., Stępnicki, Piotr, Koszła, Oliwia, Kędzierska, Ewa, Bartyzel, Agata, Biała, Grażyna, Matosiuk, Dariusz, Loza, Maria I., Castro, Marián, Kaczor, Agnieszka A.

“…Schizophrenia is a complex disease with not fully understood pathomechanism, involving many neurotransmitters and their receptors. This is why it is best…”
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Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety by Kondej, Magda, Wróbel, Tomasz M., Targowska‐Duda, Katarzyna M., Leandro Martínez, Antón, Koszła, Oliwia, Stępnicki, Piotr, Zięba, Agata, Paz, Alba, Wronikowska‐Denysiuk, Olga, Loza, Maria I., Castro, Marián, Kaczor, Agnieszka A.

“…Schizophrenia is a complex disease which is best treated with multitarget drugs, such as atypical antipsychotics. Previously, using structure‐based virtual…”
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Multi-target derivatives of D2AAK1 as potential antipsychotics - the effect of the substitution in the indole moiety by Kondej, Magda, Wróbel, Tomasz M, Targowska-Duda, Katarzyna M, Martínez, Antón Leandro, Koszła, Oliwia, Stępnicki, Piotr, Zięba, Agata, Paz, Alba, Wronikowska-Denysiuk, Olga, Loza, Maria I, Castro, Marián, Kaczor, Agnieszka Anna

“…Schizophrenia is a complex disease which is best treated with multi-target drugs, such as atypical antipsychotics. Previously, using structure-based virtual…”
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Synthesis, Structural and Thermal Studies of 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1 H -indole (D2AAK1_3) as Dopamine D₂ Receptor Ligand by Kondej, Magda, Bartyzel, Agata, Pitucha, Monika, Wróbel, Tomasz M, Silva, Andrea G, Matosiuk, Dariusz, Castro, Marián, Kaczor, Agnieszka A

“…Compound D2AAK1_3 was designed as a modification of the lead structure D2AAK1 (an in vivo active multi-target compound with nanomolar affinity to a number of…”
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