Search Results - "Kondapalli, Chandana"
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PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
Published in Open biology (01-05-2012)“…Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive inherited Parkinson's disease (PD). We have exploited our recent discovery that…”
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Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy
Published in Nature communications (01-08-2022)“…During the early stages of Alzheimer’s disease (AD) in both mouse models and human patients, soluble forms of Amyloid-β 1–42 oligomers (Aβ42o) trigger loss of…”
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Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1
Published in The EMBO journal (12-11-2015)“…Mutations in the PTEN‐induced kinase 1 (PINK1) are causative of autosomal recessive Parkinson's disease (PD). We have previously reported that PINK1 is…”
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4
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65
Published in Biochemical journal (15-05-2014)“…We have previously reported that the Parkinson's disease-associated kinase PINK1 (PTEN-induced putative kinase 1) is activated by mitochondrial depolarization…”
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The Linker Region in Receptor Guanylyl Cyclases Is a Key Regulatory Module
Published in The Journal of biological chemistry (02-10-2009)“…Receptor guanylyl cyclases are multidomain proteins, and ligand binding to the extracellular domain increases the levels of intracellular cGMP. The…”
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Linker Region in Receptor Guanylyl Cyclases Is a Key Regulatory Module: MUTATIONAL ANALYSIS OF GUANYLYL CYCLASE C
Published in The Journal of biological chemistry (02-10-2009)“…Receptor guanylyl cyclases are multidomain proteins, and ligand binding to the extracellular domain increases the levels of intracellular cGMP. The…”
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Journal Article -
7
Phosphoproteomic screening identifies Rab GTP ases as novel downstream targets of PINK 1
Published in The EMBO journal (12-11-2015)“…Mutations in the PTEN ‐induced kinase 1 ( PINK 1) are causative of autosomal recessive Parkinson's disease ( PD ). We have previously reported that PINK 1 is…”
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Journal Article -
8
Investigation of regulation and downstream signaling pathway of parkinson's disease associated kinase, pink1
Published 01-01-2013Get full text
Dissertation