Search Results - "Konda, Prathyusha"

Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433 by Monro, Susan, Colón, Katsuya L, Yin, Huimin, Roque, John, Konda, Prathyusha, Gujar, Shashi, Thummel, Randolph P, Lilge, Lothar, Cameron, Colin G, McFarland, Sherri A

“…Transition metal complexes are of increasing interest as photosensitizers in photodynamic therapy (PDT) and, more recently, for photochemotherapy (PCT). In…”
Get full text

How splicing confers treatment resistance in prostate cancer by Konda, Prathyusha, Viswanathan, Srinivas R

“…A splice variant of the androgen receptor that drives prostate cancer resistance translocates into the nucleus using a different mechanism from the full-length…”
Get full text

Genome-guided discovery of cancer therapeutic targets by Konda, Prathyusha, Garinet, Simon, Van Allen, Eliezer M., Viswanathan, Srinivas R.

“…The success of precision oncology—which aims to match the right therapies to the right patients based on molecular status—is predicated on a robust pipeline of…”
Get full text

Closely related reovirus lab strains induce opposite expression of RIG-I/IFN-dependent versus -independent host genes, via mechanisms of slow replication versus polymorphisms in dsRNA binding σ3 respectively by Mohamed, Adil, Konda, Prathyusha, Eaton, Heather E., Gujar, Shashi, Smiley, James R., Shmulevitz, Maya

“…The Dearing isolate of Mammalian orthoreovirus (T3D) is a prominent model of virus-host relationships and a candidate oncolytic virotherapy. Closely related…”
Get full text

Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy by Konda, Prathyusha, Lifshits, Liubov M., Roque, John A., Cole, Houston D., Cameron, Colin G., McFarland, Sherri A., Gujar, Shashi

“…We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In…”
Get full text

After virus exposure, early bystander naïve CD8 T cell activation relies on NAD + salvage metabolism by Holay, Namit, Kennedy, Barry E, Murphy, J Patrick, Konda, Prathyusha, Giacomantonio, Michael, Brauer-Chapin, Tatjana, Paulo, Joao A, Kumar, Vishnupriyan, Kim, Youra, Elaghil, Mariam, Sisson, Gary, Clements, Derek, Richardson, Christopher, Gygi, Steven P, Gujar, Shashi

“…CD8 T cells play a central role in antiviral immunity. Type I interferons are among the earliest responders after virus exposure and can cause extensive…”
Get full text

NAD+ depletion enhances reovirus-induced oncolysis in multiple myeloma by Kennedy, Barry E., Giacomantonio, Michael, Murphy, J. Patrick, Cutler, Samuel, Sadek, Maryanne, Konda, Prathyusha, Paulo, Joao A., Pathak, Gopal P., Renkens, Saskia H.J., Grieve, Stacy, Pol, Jonathan, Gygi, Steven P., Richardson, Christopher, Gaston, Daniel, Reiman, Anthony, Kroemer, Guido, Elnenaei, Manal O., Gujar, Shashi A.

“…Cancer cell energy metabolism plays an important role in dictating the efficacy of oncolysis by oncolytic viruses. To understand the role of multiple myeloma…”
Get full text

ALDH1A3-regulated long non-coding RNA NRAD1 is a potential novel target for triple-negative breast tumors and cancer stem cells by Vidovic, Dejan, Huynh, Thomas T., Konda, Prathyusha, Dean, Cheryl, Cruickshank, Brianne M., Sultan, Mohammad, Coyle, Krysta M., Gujar, Shashi, Marcato, Paola

“…To discover novel therapeutic targets for triple-negative breast cancer (TNBC) and cancer stem cells (CSCs), we screened long non-coding RNAs (lncRNAs) most…”
Get full text

Dissection of tumor-intrinsic and tumor-extrinsic features of MiT/TFE translocation renal cell carcinoma via single-cell RNA sequencing by Konda, Prathyusha, Einstein, David J, Zhang, Cheng-Zhong, Choueiri, Toni, Viswanathan, Srinivas

Get full text

Tutorial: design, production and testing of oncolytic viruses for cancer immunotherapy by Gujar, Shashi, Pol, Jonathan G., Kumar, Vishnupriyan, Lizarralde-Guerrero, Manuela, Konda, Prathyusha, Kroemer, Guido, Bell, John C.

“…Oncolytic viruses (OVs) represent a novel class of cancer immunotherapy agents that preferentially infect and kill cancer cells and promote protective…”
Get full text

Improving MHC‐I Ligand Identifications from LC‐MS/MS Data by Incorporating Allelic Peptide Motifs by Konda, Prathyusha, Murphy, J. Patrick, Gujar, Shashi

“…MHC class I (MHC‐I)‐bound ligands play a pivotal role in CD8 T cell immunity and are hence of major interest in understanding and designing immunotherapies…”
Get full text

Cytokines in oncolytic virotherapy by Pol, Jonathan G., Workenhe, Samuel T., Konda, Prathyusha, Gujar, Shashi, Kroemer, Guido

“…Tumors represent a hostile environment for the effector cells of cancer immunosurveillance. Immunosuppressive receptors and soluble or membrane-bound ligands…”
Get full text

Improving MHC-I Ligand Identification by Incorporating Targeted Searches of Mass Spectrometry Data by Konda, Prathyusha, Murphy, J Patrick, Gujar, Shashi

“…Effective immunotherapies rely on specific activation of immune cells. Class I major histocompatibility complex (MHC-I) bound peptide ligands play a major role…”
Get more information

Near-infrared absorbing Ru() complexes act as immunoprotective photodynamic therapy (PDT) agents against aggressive melanoma by Lifshits, Liubov M, Roque III, John A, Konda, Prathyusha, Monro, Susan, Cole, Houston D, von Dohlen, David, Kim, Susy, Deep, Gagan, Thummel, Randolph P, Cameron, Colin G, Gujar, Shashi, McFarland, Sherri A

“…Mounting evidence over the past 20 years suggests that photodynamic therapy (PDT), an anticancer modality known mostly as a local treatment, has the capacity…”
Get full text

Immune Checkpoint Blockade Augments Changes Within Oncolytic Virus-induced Cancer MHC-I Peptidome, Creating Novel Antitumor CD8 T Cell Reactivities by Kim, Youra, Konda, Prathyusha, Murphy, J. Patrick, Paulo, Joao A., Gygi, Steven P., Gujar, Shashi

“…The combination cancer immunotherapies with oncolytic virus (OV) and immune checkpoint blockade (ICB) reinstate otherwise dysfunctional antitumor CD8 T cell…”
Get full text

Closely related reovirus lab strains induce opposite expression of RIG-I/IFN-dependent versus -independent host genes, via mechanisms of slow replication versus polymorphisms in dsRNA binding [sigma]3 respectively by Mohamed, Adil, Konda, Prathyusha, Eaton, Heather E, Gujar, Shashi, Smiley, James R, Shmulevitz, Maya, Ou, Jing-hsiung James, Boehme, Karl

“…The Dearing isolate of Mammalian orthoreovirus (T3D) is a prominent model of virus-host relationships and a candidate oncolytic virotherapy. Closely related…”
Get full text

RTN4 Knockdown Dysregulates the AKT Pathway, Destabilizes the Cytoskeleton, and Enhances Paclitaxel-Induced Cytotoxicity in Cancers by Pathak, Gopal P., Shah, Rashmi, Kennedy, Barry E., Murphy, J. Patrick, Clements, Derek, Konda, Prathyusha, Giacomantonio, Michael, Xu, Zhaolin, Schlaepfer, Isabel R., Gujar, Shashi

“…[Display omitted] Reticulon-4 (RTN4), commonly known as a neurite outgrowth inhibitor (Nogo), is emerging as an important player in human cancers. Clinically,…”
Get full text

MHC‑I Ligand Discovery Using Targeted Database Searches of Mass Spectrometry Data: Implications for T‑Cell Immunotherapies by Murphy, J. Patrick, Konda, Prathyusha, Kowalewski, Daniel J, Schuster, Heiko, Clements, Derek, Kim, Youra, Cohen, Alejandro M, Sharif, Tanveer, Nielsen, Morten, Stevanovic, Stefan, Lee, Patrick W, Gujar, Shashi

“…Class I major histocompatibility complex (MHC-I)-bound peptide ligands dictate the activation and specificity of CD8+ T cells and thus are important for…”
Get full text

Enhancing Mass Spectrometry-Based MHC-I Peptide Identification Through a Targeted Database Search Approach by Konda, Prathyusha, Murphy, J Patrick, Nielsen, Morten, Gujar, Shashi

“…MHC-bound peptide ligands dictate the activation and specificity of CD8+ T- cells-based and thus are important for devising T-cell immunotherapies. In recent…”
Get more information

Inhibition of Pyruvate Dehydrogenase Kinase Enhances the Antitumor Efficacy of Oncolytic Reovirus by Kennedy, Barry E, Murphy, John Patrick, Clements, Derek R, Konda, Prathyusha, Holay, Namit, Kim, Youra, Pathak, Gopal P, Giacomantonio, Michael A, Hiani, Yassine El, Gujar, Shashi

“…Oncolytic viruses (OV) such as reovirus preferentially infect and kill cancer cells. Thus, the mechanisms that dictate the susceptibility of cancer cells to…”
Get full text