Search Results - "Koncarevic, Alan"

Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle by Stevenson, Eric J, Giresi, Paul G, Koncarevic, Alan, Kandarian, Susan C

“…Muscular inactivity leads to atrophy, weakness, and decreased fatigue resistance. In order to provide a window into the dynamic processes that underlie muscle…”
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A Soluble Activin Receptor Type IIB Prevents the Effects of Androgen Deprivation on Body Composition and Bone Health by Koncarevic, Alan, Cornwall-Brady, Milton, Pullen, Abigail, Davies, Monique, Sako, Dianne, Liu, June, Kumar, Ravindra, Tomkinson, Kathleen, Baker, Theresa, Umiker, Ben, Monnell, Travis, Grinberg, Asya V, Liharska, Katia, Underwood, Kathryn W, Ucran, Jeffrey A, Howard, Elizabeth, Barberio, Joseph, Spaits, Matthew, Pearsall, Scott, Seehra, Jasbir, Lachey, Jennifer

“…Androgen deprivation, a consequence of hypogonadism, certain cancer treatments, or normal aging in men, leads to loss of muscle mass, increased adiposity, and…”
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Identification of a molecular signature of sarcopenia by Giresi, Paul G, Stevenson, Eric J, Theilhaber, Joachim, Koncarevic, Alan, Parkington, Jascha, Fielding, Roger A, Kandarian, Susan C

“…1 Department of Health Sciences, Boston University, Boston 2 Aventis Pharmaceuticals, Cambridge Genomics Center, Cambridge, Massachusetts Investigating the…”
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Transcriptional profile of a myotube starvation model of atrophy by Stevenson, Eric J, Koncarevic, Alan, Giresi, Paul G, Jackman, Robert W, Kandarian, Susan C

“…Department of Health Sciences, Boston University, Boston, Massachusetts Submitted 24 September 2004 ; accepted in final form 12 December 2004 Skeletal muscle…”
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A Novel Therapeutic Approach to Treating Obesity through Modulation of TGFβ Signaling by Koncarevic, Alan, Kajimura, Shingo, Cornwall-Brady, Milton, Andreucci, Amy, Pullen, Abigail, Sako, Dianne, Kumar, Ravindra, Grinberg, Asya V, Liharska, Katia, Ucran, Jeffrey A, Howard, Elizabeth, Spiegelman, Bruce M, Seehra, Jasbir, Lachey, Jennifer

“…Obesity results from disproportionately high energy intake relative to energy expenditure. Many therapeutic strategies have focused on the intake side of the…”
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ubiquitin-protein ligase Nedd4 targets Notch1 in skeletal muscle and distinguishes the subset of atrophies caused by reduced muscle tension by Koncarevic, Alan, Jackman, Robert W, Kandarian, Susan C

“…Ubiquitination-dependent proteolysis is a fundamental process underlying skeletal muscle atrophy. Thus, the role of ubiquitin ligases is of great interest…”
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Activation of an alternative NF‐ΚB pathway in skeletal muscle during disuse atrophy by Hunter, R. Bridge, Stevenson, Eric J., Koncarevic, Alan, Mitchell-Felton, Heather, Essig, David A., Kandarian, Susan C.

“…ABSTRACT Although cytokine‐induced nuclear factor KB (NF‐ΚB) pathways are involved in muscle wasting subsequent to disease, their potential role in disuse…”
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Testosterone stimulates muscle growth in association with PI3‐K/Akt signaling in subjects with HIV by Koncarevic, Alan, Morris, Carl A., Jasuja, Ravi, Flanagan, John, Montano, Monty, Bhasin, Shalender, LeBrasseur, Nathan K.

“…Recent evidence suggests androgens increase lean body mass and strength in subjects with HIV‐associated wasting. The molecular basis for the anabolic effects…”
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Ubiquitin -protein ligase Nedd4 regulates Notch1 in tension-sensitive models of skeletal muscle atrophy by Koncarevic, Alan

“…Skeletal muscle atrophy results from muscular inactivity as well as from disease states, and is characterized by enhanced ubiquitiniation-dependent proteolysis…”
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Role for IkappaBalpha, but not c-Rel, in skeletal muscle atrophy by Judge, Andrew R, Koncarevic, Alan, Hunter, R Bridge, Liou, Hsiou-Chi, Jackman, Robert W, Kandarian, Susan C

“…Skeletal muscle atrophy is associated with a marked and sustained activation of nuclear factor-kappaB (NF-kappaB) activity. Previous work showed that p50 is…”
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Ubiquitin-protein ligase Nedd4 regulates Notch1 in tension-sensitive models of skeletal muscle atrophy by Koncarevic, Alan

“…Skeletal muscle atrophy results from muscular inactivity as well as from disease states, and is characterized by enhanced ubiquitiniation-dependent proteolysis…”
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Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle by Stevenson, Eric J., Giresi, Paul G., Koncarevic, Alan, Kandarian, Susan C.

“…Muscular inactivity leads to atrophy, weakness, and decreased fatigue resistance. In order to provide a window into the dynamic processes that underlie muscle…”
Get full text

Activation of an alternative NF-kappaB pathway in skeletal muscle during disuse atrophy by Hunter, R Bridge, Stevenson, EricJ, Koncarevic, Alan, Mitchell-Felton, Heather, Essig, David A, Kandarian, Susan C

“…Although cytokine-induced nuclear factor kappaB (NF-kappaB) pathways are involved in muscle wasting subsequent to disease, their potential role in disuse…”
Get full text