Search Results - "Kon, Onn M."

Beyond the clot: perfusion imaging of the pulmonary vasculature after COVID-19 by Dhawan, Ranju T, Gopalan, Deepa, Howard, Luke, Vicente, Angelito, Park, Mirae, Manalan, Kavina, Wallner, Ingrid, Marsden, Peter, Dave, Surendra, Branley, Howard, Russell, Georgina, Dharmarajah, Nishanth, Kon, Onn M

“…A compelling body of evidence points to pulmonary thrombosis and thromboembolism as a key feature of COVID-19. As the pandemic spread across the globe over the…”
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Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium by Slater, Louise, Bartlett, Nathan W, Haas, Jennifer J, Zhu, Jie, Message, Simon D, Walton, Ross P, Sykes, Annemarie, Dahdaleh, Samer, Clarke, Deborah L, Belvisi, Maria G, Kon, Onn M, Fujita, Takashi, Jeffery, Peter K, Johnston, Sebastian L, Edwards, Michael R

“…The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I and MDA5 in viral infection is much debated. We investigated the…”
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Rhinovirus Infection Induces Degradation of Antimicrobial Peptides and Secondary Bacterial Infection in Chronic Obstructive Pulmonary Disease by MALLIA, Patrick, FOOTITT, Joseph, MESSAGE, Simon D, ITO, Kazuhiro, BARNES, Peter J, ADCOCK, Ian M, PAPI, Alberto, STANCIU, Luminita A, ELKIN, Sarah L, KON, Onn M, JOHNSON, Malcolm, JOHNSTON, Sebastian L, SOTERO, Rosa, JEPSON, Annette, CONTOLI, Marco, TRUJILLO-TORRALBO, Maria-Belen, KEBADZE, Tatiana, ANISCENKO, Julia, OLESZKIEWICZ, Gregory, GRAY, Katrina

“…Chronic obstructive pulmonary disease (COPD) exacerbations are associated with virus (mostly rhinovirus) and bacterial infections, but it is not known whether…”
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Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production by Message, Simon D, Laza-Stanca, Vasile, Mallia, Patrick, Parker, Hayley L, Zhu, Jie, Kebadze, Tatiana, Contoli, Marco, Sanderson, Gwen, Kon, Onn M, Papi, Alberto, Jeffery, Peter K, Stanciu, Luminita A, Johnston, Sebastian L

“…Acute exacerbations are the major cause of asthma morbidity, mortality, and health-care costs and are difficult to treat and prevent. The majority of asthma…”
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Rv3615c is a highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis infection by Millington, Kerry A, Fortune, Sarah M, Low, Jeffrey, Garces, Alejandra, Hingley-Wilson, Suzanne M, Wickremasinghe, Melissa, Kon, Onn M, Lalvani, Ajit

“…The 6-kDa early secretory antigenic target of Mycobacterium tuberculosis (ESAT-6) and the 10-kDa culture filtrate antigen (CFP-10), encoded in region of…”
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Proteomic Analysis of Kveim Reagent Identifies Targets of Cellular Immunity in Sarcoidosis by Eberhardt, Christian, Thillai, Muhunthan, Parker, Robert, Siddiqui, Nazneen, Potiphar, Lee, Goldin, Rob, Timms, John F, Wells, Athol U, Kon, Onn M, Wickremasinghe, Melissa, Mitchell, Donald, Weeks, Mark E, Lalvani, Ajit

“…Kveim-reagent (Kv) skin testing was a historical method of diagnosing sarcoidosis. Intradermal injection of treated sarcoidosis spleen tissue resulted in a…”
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Airway Inflammation and Illness Severity in Response to Experimental Rhinovirus Infection in Asthma by Zhu, Jie, MD, PhD, Message, Simon D., MD, PhD, Qiu, Yusheng, MD, PhD, Mallia, Patrick, MD, PhD, Kebadze, Tatiana, MD, Contoli, Marco, MD, Ward, Christine K., PhD, Barnathan, Elliot S., MD, Mascelli, Mary Ann, PhD, Kon, Onn M., MD, Papi, Alberto, MD, FCCP, Stanciu, Luminita A., MD, PhD, Jeffery, Peter K., PhD, DSc, Johnston, Sebastian L., PhD

“…Background The nature of bronchial mucosal inflammation and its physiologic and clinical significance in rhinovirus-induced asthma exacerbations is unclear. We…”
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Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD by Footitt, Joseph, PhD, Mallia, Patrick, PhD, Durham, Andrew L., PhD, Ho, W. Eugene, PhD, Trujillo-Torralbo, Maria-Belen, BSc, Telcian, Aurica G., PhD, Del Rosario, Ajerico, BSc, Chang, Cheng, PhD, Peh, Hong-Yong, MSc, Kebadze, Tatiana, MD, Aniscenko, Julia, Stanciu, Luminita, PhD, Essilfie-Quaye, Sarah, PhD, Ito, Kazuhiro, PhD, Barnes, Peter J., FCCP, Elkin, Sarah L., PhD, Kon, Onn M., MD, Wong, W. S. Fred, PhD, Adcock, Ian M., PhD, Johnston, Sebastian L., PhD

“…Background Respiratory virus infections are commonly associated with COPD exacerbations, but little is known about the mechanisms linking virus infection to…”
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Time to diagnosis of tuberculosis is greater in older patients: a retrospective cohort review by Abbara, Aula, Collin, Simon M, Kon, Onn M, Buell, Kevin, Sullivan, Adam, Barrett, Jessica, Corrah, Tumena, McGregor, Alastair, Hansel, Trevor, John, Laurence, Davidson, Robert N

“…Age-related immunosenescence influences the presentation of tuberculosis (TB) in older patients. Here, we explore the clinical and radiological presentation of…”
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PD-1 Expression and Cytokine Secretion Profiles of Mycobacterium tuberculosis-Specific CD4+ T-Cell Subsets; Potential Correlates of Containment in HIV-TB Co-Infection by Pollock, Katrina M, Montamat-Sicotte, Damien J, Grass, Lisa, Cooke, Graham S, Kapembwa, Moses S, Kon, Onn M, Sampson, Robert D, Taylor, Graham P, Lalvani, Ajit

“…HIV co-infection is an important risk factor for tuberculosis (TB) providing a powerful model in which to dissect out defective, protective and dysfunctional…”
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Rhinovirus induction of fractalkine (CX3CL1) in airway and peripheral blood mononuclear cells in asthma by Upton, Nadine, Jackson, David J, Nikonova, Alexandra A, Hingley-Wilson, Suzie, Khaitov, Musa, Del Rosario, Ajerico, Traub, Stephanie, Trujillo-Torralbo, Maria-Belen, Habibi, Max, Elkin, Sarah L, Kon, Onn M, Edwards, Michael R, Mallia, Patrick, Footitt, Joseph, Macintyre, Jonathan, Stanciu, Luminita A, Johnston, Sebastian L, Sykes, Annemarie

“…Rhinovirus infection is associated with the majority of asthma exacerbations. The role of fractalkine in anti-viral (type 1) and pathogenic (type 2) responses…”
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The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations by Laza-Stanca, Vasile, Message, Simon D, Edwards, Michael R, Parker, Hayley L, Zdrenghea, Mihnea T, Kebadze, Tatiana, Kon, Onn M, Mallia, Patrick, Stanciu, Luminita A, Johnston, Sebastian L

“…Rhinovirus infections are the major cause of asthma exacerbations. We hypothesised that IL-15, a cytokine implicated in innate and acquired antiviral immunity,…”
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An experimental model of rhinovirus induced chronic obstructive pulmonary disease exacerbations: a pilot study by Mallia, Patrick, Message, Simon D, Kebadze, Tatiana, Parker, Hayley L, Kon, Onn M, Johnston, Sebastian L

“…Acute exacerbations of COPD are a major cause of morbidity, mortality and hospitalisation. Respiratory viruses are associated with the majority of…”
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Effect of Treatment of Latent Tuberculosis Infection on the T Cell Response to Mycobacterium tuberculosis Antigens by Wilkinson, Katalin A., Kon, Onn M., Newton, Sandra M., Meintjes, Graeme, Davidson, Robert N., Pasvol, Geoffrey, Wilkinson, Robert J.

“…Most cases of latent tuberculosis infection (LTBI) do not cause symptoms during the lifetime of the infected person. Longitudinal analysis of the immune…”
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Soluble Major Histocompatibility Complex Class I-Related Chain B Molecules Are Increased and Correlate With Clinical Outcomes During Rhinovirus Infection in Healthy Subjects by Telcian, Aurica G., MD, PhD, Zdrenghea, Mihnea T., MD, PhD, Caramori, Gaetano, MD, PhD, Laza-Stanca, Vasile, MD, PhD, Message, Simon D., MD, PhD, Kebadze, Tatiana, MD, Kon, Onn M., MD, PhD, Groh, Veronika, PhD, Papi, Alberto, MD, PhD, FCCP, Johnston, Sebastian L., MD, PhD, Mallia, Patrick, MD, PhD, Stanciu, Luminita A., MD, PhD

“…BACKGROUND Surface major histocompatibility complex class I-related chain (MIC) A and B molecules are increased by IL-15 and have a role in the activation of…”
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An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis by O'Garra, Anne, Berry, Matthew P. R, Graham, Christine M, McNab, Finlay W, Xu, Zhaohui, Bloch, Susannah A. A, Oni, Tolu, Wilkinson, Katalin A, Banchereau, Romain, Skinner, Jason, Wilkinson, Robert J, Quinn, Charles, Blankenship, Derek, Dhawan, Ranju, Cush, John J, Mejias, Asuncion, Ramilo, Octavio, Kon, Onn M, Pascual, Virginia, Banchereau, Jacques, Chaussabel, Damien

“…Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of morbidity and mortality worldwide. Efforts to control it are…”
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Bronchial mucosal IFN-α/β and pattern recognition receptor expression in patients with experimental rhinovirus-induced asthma exacerbations by Zhu, Jie, Message, Simon D., Mallia, Patrick, Kebadze, Tatiana, Contoli, Marco, Ward, Christine K., Barnathan, Elliot S., Mascelli, Mary Ann, Kon, Onn M., Papi, Alberto, Stanciu, Luminita A., Edwards, Michael R., Jeffery, Peter K., Johnston, Sebastian L.

“…The innate immune system senses viral infection through pattern recognition receptors (PRRs), leading to type I interferon production. The role of type I…”
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Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza by Dunning, Jake, Blankley, Simon, Hoang, Long T., Cox, Mike, Graham, Christine M., James, Philip L., Bloom, Chloe I., Chaussabel, Damien, Banchereau, Jacques, Brett, Stephen J., Moffatt, Miriam F., O’Garra, Anne, Openshaw, Peter J. M.

“…Transcriptional profiles and host-response biomarkers are used increasingly to investigate the severity, subtype and pathogenesis of disease. We now describe…”
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Experimental Rhinovirus Infection as a Human Model of Chronic Obstructive Pulmonary Disease Exacerbation by MALLIA, Patrick, MESSAGE, Simon D, PAPI, Alberto, STANCIU, Luminita A, KON, Onn M, JOHNSON, Malcolm, JOHNSTON, Sebastian L, GIELEN, Vera, CONTOLI, Marco, GRAY, Katrina, KEBADZE, Tatiana, ANISCENKO, Julia, LAZA-STANCA, Vasile, EDWARDS, Michael R, SLATER, Louise

“…Respiratory virus infections are associated with chronic obstructive pulmonary disease (COPD) exacerbations, but a causative relationship has not been proven…”
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Role of deficient type III interferon-λ production in asthma exacerbations by Johnston, Sebastian L, Contoli, Marco, Message, Simon D, Laza-Stanca, Vasile, Edwards, Michael R, Wark, Peter A B, Bartlett, Nathan W, Kebadze, Tatiana, Mallia, Patrick, Stanciu, Luminita A, Parker, Hayley L, Slater, Louise, Lewis-Antes, Anita, Kon, Onn M, Holgate, Stephen T, Davies, Donna E, Kotenko, Sergei V, Papi, Alberto

“…Rhinoviruses are the major cause of asthma exacerbations, and asthmatics have increased susceptibility to rhinovirus and risk of invasive bacterial infections…”
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