Search Results - "Kon, Kazuyoshi"

Topics in alcohol-associated/related liver disease by Kon, Kazuyoshi

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Pathogenesis and epidemiology of alcohol-associated/related liver disease by Kon, Kazuyoshi

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Nonalcoholic fatty liver disease and alcohol-related liver disease: From clinical aspects to pathophysiological insights by Ikejima, Kenichi, Kon, Kazuyoshi, Yamashina, Shunhei

“…Two major causes of steatohepatitis are alcohol and metabolic syndrome. Although the underlying causes of alcoholrelated liver disease (ALD) and nonalcoholic…”
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Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease by Fukuo, Yuka, Yamashina, Shunhei, Sonoue, Hiroshi, Arakawa, Atsushi, Nakadera, Eisuke, Aoyama, Tomonori, Uchiyama, Akira, Kon, Kazuyoshi, Ikejima, Kenichi, Watanabe, Sumio

“…Aim Recent evidences indicate that hepatic steatosis suppresses autophagic proteolysis. The present study evaluated the correlation between autophagic function…”
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Proposal of Stroop test cut‐off values as screening for neuropsychological impairments in cirrhosis: A Japanese multicenter study by Kondo, Yasuteru, Iwasa, Motoh, Kawaratani, Hideto, Miyaaki, Hisamitsu, Hanai, Tatsunori, Kon, Kazuyoshi, Hirano, Hirotaka, Shimizu, Masahito, Yoshiji, Hitoshi, Okita, Kiwamu, Koike, Kazuhiko

“…Aim Despite its relevant clinical impact and high prevalence, covert hepatic encephalopathy (HE) still remains underdiagnosed. As patients with liver cirrhosis…”
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Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress by Kusama, Hiromi, Kon, Kazuyoshi, Ikejima, Kenichi, Arai, Kumiko, Aoyama, Tomonori, Uchiyama, Akira, Yamashina, Shunhei, Watanabe, Sumio

“…Background Acetaminophen (APAP) overdose induces severe oxidative stress followed by hepatocyte apoptosis/necrosis. Previous studies have indicated that…”
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Formation of p62‐positive inclusion body is associated with macrophage polarization in non‐alcoholic fatty liver disease by Fukushima, Hirofumi, Yamashina, Shunhei, Arakawa, Atsushi, Taniguchi, Gentaro, Aoyama, Tomonori, Uchiyama, Akira, Kon, Kazuyoshi, Ikejima, Kenichi, Watanabe, Sumio

“…Aim Hepatic inclusion composed of autophagy‐specific substrate p62 is one of the histological features of non‐alcoholic fatty liver disease (NAFLD) and can be…”
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Carbohydrate-deficient transferrin is a sensitive marker of alcohol consumption in fatty liver disease by Morinaga, Maki, Kon, Kazuyoshi, Uchiyama, Akira, Fukada, Hiroo, Fukuhara, Kyoko, Yaginuma, Reiko, Nakadera, Eisuke, Yamashina, Shunhei, Ikejima, Kenichi

“…Background The prevalence of nonalcoholic fatty liver disease (NAFLD) and alcohol-associated/related liver disease (ALD) with metabolic syndrome is increasing…”
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Mitochondrial permeability transition in acetaminophen‐induced necrosis and apoptosis of cultured mouse hepatocytes by Kon, Kazuyoshi, Kim, Jae‐Sung, Jaeschke, Hartmut, Lemasters, John J.

“…Acetaminophen overdose causes massive hepatic failure via mechanisms involving glutathione depletion, oxidative stress, and mitochondrial dysfunction. The…”
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Aging exacerbates high‐fat diet‐induced steatohepatitis through alteration in hepatic lipid metabolism in mice by Ishizuka, Kei, Kon, Kazuyoshi, Lee‐Okada, Hyeon‐Cheol, Arai, Kumiko, Uchiyama, Akira, Yamashina, Shunhei, Yokomizo, Takehiko, Ikejima, Kenichi

“…Background and Aim Aging is an independent risk factor for the progression of non‐alcoholic steatohepatitis. Here, we investigated the role of age‐related…”
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Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells by Wang, Xu, Ikejima, Kenichi, Kon, Kazuyoshi, Arai, Kumiko, Aoyama, Tomonori, Okumura, Kyoko, Abe, Wataru, Sato, Nobuhiro, Watanabe, Sumio

“…Background & Aims Specific induction of cell death in activated hepatic stellate cells (HSCs) is a promising therapeutic strategy for hepatic fibrosis. In this…”
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The Chemical Chaperone 4‐Phenylbutyric Acid Prevents Alcohol‐Induced Liver Injury in Obese KK‐Ay Mice by Suzuki, Maiko, Kon, Kazuyoshi, Ikejima, Kenichi, Arai, Kumiko, Uchiyama, Akira, Aoyama, Tomonori, Yamashina, Shunhei, Ueno, Takashi, Watanabe, Sumio

“…Background Co‐occurrence of metabolic syndrome and chronic alcohol consumption is increasing worldwide. The present study investigated the effect of the…”
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Inhibition of mTOR improves the impairment of acidification in autophagic vesicles caused by hepatic steatosis by Nakadera, Eisuke, Yamashina, Shunhei, Izumi, Kousuke, Inami, Yoshihiro, Sato, Toshifumi, Fukushima, Hirofumi, Kon, Kazuyoshi, Ikejima, Kenichi, Ueno, Takashi, Watanabe, Sumio

“…Recent investigations revealed that dysfunction of autophagy involved in the progression of chronic liver diseases such as alcoholic and nonalcoholic…”
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Lysosomal Iron Mobilization and Induction of the Mitochondrial Permeability Transition in Acetaminophen-Induced Toxicity to Mouse Hepatocytes by Kon, Kazuyoshi, Kim, Jae-Sung, Uchiyama, Akira, Jaeschke, Hartmut, Lemasters, John J.

“…Acetaminophen induces the mitochondrial permeability transition (MPT) in hepatocytes. Reactive oxygen species (ROS) trigger the MPT and play an important role…”
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Glycine prevents metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity by Takashima, Shiori, Ikejima, Kenichi, Arai, Kumiko, Yokokawa, Junko, Kon, Kazuyoshi, Yamashina, Shunhei, Watanabe, Sumio

“…Strategies for prevention and treatment of nonalcoholic steatohepatitis remain to be established. We evaluated the effect of glycine on metabolic…”
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The impact of PNPLA3 and JAZF1 on hepatocellular carcinoma in non-viral hepatitis patients with type 2 diabetes mellitus by Ueyama, Misuzu, Nishida, Nao, Korenaga, Masaaki, Korenaga, Keiko, Kumagai, Erina, Yanai, Hidekatsu, Adachi, Hiroki, Katsuyama, Hisayuki, Moriyama, Sumie, Hamasaki, Hidetaka, Sako, Akahito, Sugiyama, Masaya, Aoki, Yoshihiko, Imamura, Masatoshi, Murata, Kazumoto, Masaki, Naohiko, Kawaguchi, Takumi, Torimura, Takuji, Hyogo, Hideyuki, Aikata, Hiroshi, Ito, Kiyoaki, Sumida, Yoshio, Kanazawa, Akio, Watada, Hirotaka, Okamoto, Koji, Honda, Kenjiro, Kon, Kazuyoshi, Kanto, Tatsuya, Mizokami, Masashi, Watanabe, Sumio

“…Background Type 2 diabetes mellitus (T2DM) is an established independent risk factor for hepatocellular carcinoma (HCC). T2DM is associated with non-alcoholic…”
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Role of adipocytokines in hepatic fibrogenesis by Ikejima, Kenichi, Okumura, Kyoko, Kon, Kazuyoshi, Takei, Yoshiyuki, Sato, Nobuhiro

“…Obesity and insulin resistance are the key factors for progression of hepatic fibrosis in various chronic liver diseases including non‐alcoholic…”
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A Customized Online Nutrition Guidance System Is Effective for Treating Patients with Nonalcoholic Fatty Liver Disease by Supporting Continuity of Diet Therapy at Home: A Pilot Study by Aoyama, Tomonori, Takada, Hidekatsu, Uchiyama, Akira, Kon, Kazuyoshi, Yamashina, Shunhei, Ikejima, Kenichi, Ban, Hideyuki, Watanabe, Sumio

“…Continuity is required for diet therapy, but it depends on patients. We examined the utility of a new tool, the customized online nutrition guidance system, in…”
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L‐carnitine prevents metabolic steatohepatitis in obese diabetic KK‐Ay mice by Kon, Kazuyoshi, Ikejima, Kenichi, Morinaga, Maki, Kusama, Hiromi, Arai, Kumiko, Aoyama, Tomonori, Uchiyama, Akira, Yamashina, Shunhei, Watanabe, Sumio

“…Aim Pharmacological treatment for metabolic syndrome‐related non‐alcoholic steatohepatitis has not been established. We investigated the effect of L‐carnitine,…”
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Decreased Expression of Phosphatase and Tensin Homolog Is Related with the Development of Non-B and Non-C Hepatocellular Carcinoma by SORIN, YUSHI, KON, KAZUYOSHI, SONOUE, HIROSHI, UCHIYAMA, AKIRA, FUKUHARA, KYOKO, YAMASHINA, SHUNHEI, ARAKAWA, ATSUSHI, IKEJIMA, KENICHI

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