Search Results - "Komori, H Kiyomi"

Library construction for next-generation sequencing: overviews and challenges by Head, Steven R, Komori, H Kiyomi, LaMere, Sarah A, Whisenant, Thomas, Van Nieuwerburgh, Filip, Salomon, Daniel R, Ordoukhanian, Phillip

“…High-throughput sequencing, also known as next-generation sequencing (NGS), has revolutionized genomic research. In recent years, NGS technology has steadily…”
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H3K27 Methylation Dynamics during CD4 T Cell Activation: Regulation of JAK/STAT and IL12RB2 Expression by JMJD3 by LaMere, Sarah A, Thompson, Ryan C, Meng, Xiangzhi, Komori, H Kiyomi, Mark, Adam, Salomon, Daniel R

“…The changes to the epigenetic landscape in response to Ag during CD4 T cell activation have not been well characterized. Although CD4 T cell subsets have been…”
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Method for improved Illumina sequencing library preparation using NuGEN Ovation RNA-Seq System by Head, Steven R, Komori, H Kiyomi, Hart, G Traver, Shimashita, John, Schaffer, Lana, Salomon, Daniel R, Ordoukhanian, Phillip T

“…In this study, we tested the NuGEN Ovation RNA-Seq System for library preparation followed by next-generation sequencing on an Illumina GAIIx. The cDNA product…”
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The Selective Sphingosine 1-Phosphate Receptor Modulator Etrasimod Regulates Lymphocyte Trafficking and Alleviates Experimental Colitis by Al-Shamma, Hussien, Lehmann-Bruinsma, Karin, Carroll, Chris, Solomon, Michelle, Komori, H Kiyomi, Peyrin-Biroulet, Laurent, Adams, John

“…Lymphocyte trafficking out of secondary lymphoid organs is regulated by concentration gradient-dependent interactions between the membrane-derived…”
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The Long Third Complementarity-Determining Region of the Heavy Chain Is Important in the Activity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5 by ZWICK, Michael B, KOMORI, H. Kiyomi, STANFIELD, Robyn L, CHURCH, Sarah, MENG WANG, PARREN, Paul W. H. I, KUNERT, Renate, KATINGER, Hermann, WILSON, Ian A, BURTON, Dennis R

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Finding the active genes in deep RNA-seq gene expression studies by Hart, Traver, Komori, H Kiyomi, LaMere, Sarah, Podshivalova, Katie, Salomon, Daniel R

“…Early application of second-generation sequencing technologies to transcript quantitation (RNA-seq) has hinted at a vast mammalian transcriptome, including…”
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S759 Model-Predicted Lymphocyte Response and Recovery Profiles for the Sphingosine 1-Phosphate Receptor Modulators Ozanimod and Etrasimod by Lee, Caroline A., Waterhouse, Timothy, Heathman, Michael, Oh, D. Alex, Komori, H. Kiyomi, Grundy, John S.

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New opportunities for organ transplantation research: epigenetics is likely to be an important determinant of the host immune response by LaMere, Sarah A, Komori, H Kiyomi, Salomon, Daniel R

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Defining CD4 T cell memory by the epigenetic landscape of CpG DNA methylation by Komori, H Kiyomi, Hart, Traver, LaMere, Sarah A, Chew, Pamela V, Salomon, Daniel R

“…Memory T cells are primed for rapid responses to Ag; however, the molecular mechanisms responsible for priming remain incompletely defined. CpG methylation in…”
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S1137 The Impact of Etrasimod on the Transcriptome in Colon Biopsies Using RNA-Seq: Data from ELEVATE UC 52 and ELEVATE UC 12 Phase 3 Clinical Trials by Siegmund, Britta, Crosby, Catherine M., Ryan, Rathi D., Abreu, Maria T., Vermeire, Séverine, Dotan, Iris, Rabinowitz, Keren M., Guo, Xiang, Komori, H. Kiyomi, Goetsch, Martina, Woolcott, John C., Danese, Silvio

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S1138 Characterization of the Effect of Etrasimod on Peripheral Blood Mononuclear Cells: Data From ELEVATE UC 52 and ELEVATE UC 12 Phase 3 Clinical Trials by Siegmund, Britta, Ryan, Rathi D., Crosby, Catherine M., Abreu, Maria T., Vermeire, Séverine, Dotan, Iris, Rabinowitz, Keren M., Guo, Xiang, Komori, H. Kiyomi, Goetsch, Martina, Woolcott, John C., Danese, Silvio

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S928 Effect of Etrasimod on Circulating Lymphocytes in Patients With Moderately to Severely Active Ulcerative Colitis: Data From the Phase 3 ELEVATE UC 52 and ELEVATE UC 12 Trials by Danese, Silvio, Komori, H. Kiyomi, Ryan, Rathi D., Cataldi, Fabio, Lee, Caroline A., Goetsch, Martina, Siegmund, Britta

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Cutting edge: dendritic epidermal γδ T cell ligands are rapidly and locally expressed by keratinocytes following cutaneous wounding by Komori, H Kiyomi, Witherden, Deborah A, Kelly, Ryan, Sendaydiego, Kevin, Jameson, Julie M, Teyton, Luc, Havran, Wendy L

“…TCR-specific activation is pivotal to dendritic epidermal T cell (DETC) function during cutaneous wound repair. However, DETC TCR ligands are uncharacterized,…”
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Microdroplet PCR for Highly Multiplexed Targeted Bisulfite Sequencing by Komori, H Kiyomi, LaMere, Sarah A, Hart, Traver, Head, Steven R, Torkamani, Ali, Salomon, Daniel R

“…Many methods exist for examining CpG DNA methylation. However, many of these are qualitative, laborious to apply to a large number of genes simultaneously, or…”
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Application of microdroplet PCR for large-scale targeted bisulfite sequencing by Komori, H Kiyomi, LaMere, Sarah A, Torkamani, Ali, Hart, G Traver, Kotsopoulos, Steve, Warner, Jason, Samuels, Michael L, Olson, Jeff, Head, Steven R, Ordoukhanian, Phillip, Lee, Pauline L, Link, Darren R, Salomon, Daniel R

“…Cytosine methylation of DNA CpG dinucleotides in gene promoters is an epigenetic modification that regulates gene transcription. While many methods exist to…”
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Dendritic epidermal T-cell activation by Sharp, Leslie L, Jameson, Julie M, Witherden, Deborah A, Komori, H Kiyomi, Havran, Wendy L

“…Although gammadelta T cells compose a small proportion of lymphocytes in lymphoid compartments and peripheral blood, they are the major T-cell population…”
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Tu1724 EFFECT OF ETRASIMOD ON IMMUNE CELL SUBSETS IN COLONIC TISSUE OF PATIENTS WITH ULCERATIVE COLITIS: IMMUNOPHENOTYPING ANALYSIS OF COLON BIOPSY SAMPLES FROM THE PHASE 3 ELEVATE UC 52 AND ELEVATE UC 12 TRIALS by Siegmund, Britta, Komori, H. Kiyomi, Abreu, Maria T., Vermeire, Séverine, Dotan, Iris, Goetsch, Martina, Crosby, Catherine, Ryan, Rathi D., Woolcott, John, Danese, Silvio

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Su1736 CHARACTERIZATION OF PLASMA INFLAMMATORY PROTEIN ABUNDANCE IN PATIENTS WITH ULCERATIVE COLITIS TREATED WITH ETRASIMOD: AN EXPLORATORY ANALYSIS OF THE PHASE 3 ELEVATE UC 52 AND ELEVATE UC 12 TRIALS by Siegmund, Britta, Ryan, Rathi D., Abreu, Maria T., Vermeire, Séverine, Dotan, Iris, Goetsch, Martina, Crosby, Catherine, Woolcott, John, Komori, H. Kiyomi, Danese, Silvio

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APD588, a novel, selective S1P- receptor modulator, inhibits inflammation and airway hyperresponsiveness in the ovalbumin-induced model of allergic asthma by Crosby, Catherine Marie, Komori, H. Kiyomi, Christopher, Ronald, Adams, John W

“…Abstract Background FTY720 is a non-selective sphingosine-1-phosphate (S1P) receptor modulator that has shown efficacy in mouse asthma models. APD588 is an…”
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TCR-ligand interactions are required for murine epidermal Vγ3Vδ1 T cell development by Witherden, Deborah, Garijo, Olivia D, Kelly, Ryan, Komori, H. Kiyomi, Havran, Wendy L

“…Abstract Dendritic epidermal T cells (DETC), which bear the Vγ3Vδ1 T cell receptor (TCR), are the exclusive T cell population resident in the murine epidermis…”
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