Search Results - "Komor, Malgorzata"

Widespread and Functional RNA Circularization in Localized Prostate Cancer by Chen, Sujun, Huang, Vincent, Xu, Xin, Livingstone, Julie, Soares, Fraser, Jeon, Jouhyun, Zeng, Yong, Hua, Junjie Tony, Petricca, Jessica, Guo, Haiyang, Wang, Miranda, Yousif, Fouad, Zhang, Yuzhe, Donmez, Nilgun, Ahmed, Musaddeque, Volik, Stas, Lapuk, Anna, Chua, Melvin L.K., Heisler, Lawrence E., Foucal, Adrien, Fox, Natalie S., Fraser, Michael, Bhandari, Vinayak, Shiah, Yu-Jia, Guan, Jiansheng, Li, Jixi, Orain, Michèle, Picard, Valérie, Hovington, Hélène, Bergeron, Alain, Lacombe, Louis, Fradet, Yves, Têtu, Bernard, Liu, Stanley, Feng, Felix, Wu, Xue, Shao, Yang W., Komor, Malgorzata A., Sahinalp, Cenk, Collins, Colin, Hoogstrate, Youri, de Jong, Mark, Fijneman, Remond J.A., Fei, Teng, Jenster, Guido, van der Kwast, Theodorus, Bristow, Robert G., Boutros, Paul C., He, Housheng Hansen

“…The cancer transcriptome is remarkably complex, including low-abundance transcripts, many not polyadenylated. To fully characterize the transcriptome of…”
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Consensus molecular subtype classification of colorectal adenomas by Komor, Malgorzata A, Bosch, Linda JW, Bounova, Gergana, Bolijn, Anne S, Delis‐van Diemen, Pien M, Rausch, Christian, Hoogstrate, Youri, Stubbs, Andrew P, de Jong, Mark, Jenster, Guido, van Grieken, Nicole CT, Carvalho, Beatriz, Wessels, Lodewyk FA, Jimenez, Connie R, Fijneman, Remond JA, Meijer, Gerrit A, Dits, Natasja, Bottcher, Rene, Hiemstra, Annemieke C, Ylstra, Bauke, Sie, Daoud, van den Broek, Evert, van der Meer, David, Pepers, Floor, Caldenhoven, Eric, Janssen, Bart, van Workum, Wilbert, van Lieshout, Stef, Bangma, Chris H., van Leenders, Geert, van de Werken, Harmen

“…Consensus molecular subtyping is an RNA expression‐based classification system for colorectal cancer (CRC). Genomic alterations accumulate during CRC…”
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Overexpression of the miR-17-92 cluster in colorectal adenoma organoids causes a carcinoma-like gene expression signature by Martens-de Kemp, Sanne R., Komor, Malgorzata A., Hegi, Rosa, Bolijn, Anne S., Tijssen, Marianne, de Groen, Florence L.M., Depla, Annekatrien, van Leerdam, Monique, Meijer, Gerrit A., Fijneman, Remond J.A., Carvalho, Beatriz

“…Gain of chromosome arm 13q is one of the most prevalent DNA copy number alterations associated with colorectal adenoma-to-carcinoma progression. The oncogenic…”
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Proteins in stool as biomarkers for non‐invasive detection of colorectal adenomas with high risk of progression by Komor, Malgorzata A, Bosch, Linda JW, Coupé, Veerle MH, Rausch, Christian, Pham, Thang V, Piersma, Sander R, Mongera, Sandra, Mulder, Chris JJ, Dekker, Evelien, Kuipers, Ernst J, Wiel, Mark A, Carvalho, Beatriz, Fijneman, Remond JA, Jimenez, Connie R, Meijer, Gerrit A, Wit, Meike

“…Screening to detect colorectal cancer (CRC) in an early or premalignant state is an effective method to reduce CRC mortality rates. Current stool‐based…”
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Silencing Core Spliceosome Sm Gene Expression Induces a Cytotoxic Splicing Switch in the Proteasome Subunit Beta 3 mRNA in Non-Small Cell Lung Cancer Cells by Blijlevens, Maxime, Komor, Malgorzata A, Sciarrillo, Rocco, Smit, Egbert F, Fijneman, Remond J A, van Beusechem, Victor W

“…The core spliceosomal Sm proteins were recently proposed as cancer-selective lethal targets in non-small cell lung cancer (NSCLC). In contrast, the loss of the…”
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Molecular characterization of colorectal adenomas reveals POFUT1 as a candidate driver of tumor progression by Komor, Malgorzata A., Wit, Meike, Berg, Jose, Martens de Kemp, Sanne R., Delis‐van Diemen, Pien M., Bolijn, Anne S., Tijssen, Marianne, Schelfhorst, Tim, Piersma, Sander R., Chiasserini, Davide, Sanders, Joyce, Rausch, Christian, Hoogstrate, Youri, Stubbs, Andrew P., Jong, Mark, Jenster, Guido, Carvalho, Beatriz, Meijer, Gerrit A., Jimenez, Connie R., Fijneman, Remond J.A.

“…Removal of colorectal adenomas is an effective strategy to reduce colorectal cancer (CRC) mortality rates. However, as only a minority of adenomas progress to…”
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Identification of Differentially Expressed Splice Variants by the Proteogenomic Pipeline Splicify by Komor, Malgorzata A., Pham, Thang V., Hiemstra, Annemieke C., Piersma, Sander R., Bolijn, Anne S., Schelfhorst, Tim, Delis-van Diemen, Pien M., Tijssen, Marianne, Sebra, Robert P., Ashby, Meredith, Meijer, Gerrit A., Jimenez, Connie R., Fijneman, Remond J.A.

“…Proteogenomics, i.e. comprehensive integration of genomics and proteomics data, is a powerful approach identifying novel protein biomarkers. This is especially…”
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Evaluation of Cancer-Associated DNA Copy Number Events in Colorectal (Advanced) Adenomas by Carvalho, Beatriz, Diosdado, Begoña, Terhaar Sive Droste, Jochim S, Bolijn, Anne S, Komor, Malgorzata A, de Wit, Meike, Bosch, Linda J W, van Burink, Myrthe, Dekker, Evelien, Kuipers, Ernst J, Coupé, Veerle M H, van Grieken, Nicole C T, Fijneman, Remond J A, Meijer, Gerrit A

“…About 5% of colorectal adenomas are estimated to progress to colorectal cancer. However, it is important to identify which adenomas actually carry a high risk…”
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Fusion transcripts and their genomic breakpoints in polyadenylated and ribosomal RNA–minus RNA sequencing data by Hoogstrate, Youri, Komor, Malgorzata A, Böttcher, René, van Riet, Job, van de Werken, Harmen J G, van Lieshout, Stef, Hoffmann, Ralf, van den Broek, Evert, Bolijn, Anne S, Dits, Natasja, Sie, Daoud, van der Meer, David, Pepers, Floor, Bangma, Chris H, van Leenders, Geert J L H, Smid, Marcel, French, Pim J, Martens, John W M, van Workum, Wilbert, van der Spek, Peter J, Janssen, Bart, Caldenhoven, Eric, Rausch, Christian, de Jong, Mark, Stubbs, Andrew P, Meijer, Gerrit A, Fijneman, Remond J A, Jenster, Guido W

“…Abstract Background Fusion genes are typically identified by RNA sequencing (RNA-seq) without elucidating the causal genomic breakpoints. However,…”
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CRISPRs in the human genome are differentially expressed between malignant and normal adjacent to tumor tissue by van Riet, Job, Saha, Chinmoy, Strepis, Nikolaos, Brouwer, Rutger W. W., Martens-Uzunova, Elena S., van de Geer, Wesley S., Swagemakers, Sigrid M. A., Stubbs, Andrew, Halimi, Yassir, Voogd, Sanne, Tanmoy, Arif Mohammad, Komor, Malgorzata A., Hoogstrate, Youri, Janssen, Bart, Fijneman, Remond J. A., Niknafs, Yashar S., Chinnaiyan, Arul M., van IJcken, Wilfred F. J., van der Spek, Peter J., Jenster, Guido, Louwen, Rogier

“…Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) have been identified in bacteria, archaea and mitochondria of plants, but not in…”
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Abstract 4638: Colorectal adenoma-to-carcinoma progression: The role of miR-17-92 cluster by Kemp, Sanne R. Martens-de, Komor, Malgorzata A., Hegi, Rosa, Tijssen, Marianne, Bolijn, Anne S., Meijer, Gerrit A., Jimenez, Connie R., Fijneman, Remond J., Carvalho, Beatriz

“…Background Chromosomal instability plays an important role in the progression of colorectal adenoma to carcinoma. We previously observed that specific…”
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Abstract 1738: Characterization of structural variants within MACROD2 in the pathogenesis of colorectal cancer by Fijneman, Remond J A, Mekkes, Nienke, Broek, Evert van den, Stringer, Bas, Glas, Roel A., Komor, Malgorzata A., Rausch, Christian, Lieshout, Stef van, Cuppen, Edwin, Smith, Melissa L., Sebra, Robert P., Rowell, William J., Ashby, Meredith, Carvalho, Beatriz, Heringa, Jaap, Meijer, Gerrit A., Abeln, Sanne

“…Background: Cancer is caused by somatic DNA alterations, which comprise small nucleotide variants (SNVs), chromosome somatic copy number alterations (SCNAs)…”
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Abstract 1559: Proteogenomic analysis of alternative splicing in colorectal adenoma-to-carcinoma progression by Komor, Malgorzata A., Pham, Thang V., Piersma, Sander R., Bolijn, Anne S., Schelfhorst, Tim, Diemen, Pien M. Delis-van, Tijssen, Marianne, Hiemstra, Annemieke C., Wit, Meike de, Carvalho, Beatriz, Meijer, Gerrit A., Jimenez, Connie R., Fijneman, Remond J.

“…Background Early diagnosis of colorectal cancer (CRC) and identification of its precursor lesions (adenomas) is crucial in reducing CRC mortality rates. The…”
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Abstract 3676: CMS classification of colorectal adenomas by Komor, Malgorzata A., Bosch, Linda J., Bounova, Gergana, Bolijn, Anne S., Diemen, Pien Delis-van, Rausch, Christian, Hoogstrate, Youri, Stubbs, Andrew, Jong, Mark de, Jenster, Guido, Grieken, Nicole C. an, Carvalho, Beatriz, Wessels, Lodewyk, Jimenez, Connie R., Fijneman, Remond J., Meijer, Gerrit A., Consortium, NGS-ProToCol

“…Background Consensus molecular subtyping (CMS) is an RNA-expression-based classification of colorectal cancers (CRC). Genomic alterations, resulting in…”
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Abstract 848: Proteogenomic analysis of alternative splicing: the search for novel biomarkers for colorectal cancer by Komor, Malgorzata A., Hiemstra, Annemieke C., Pham, Thang V., Piersma, Sander R., Sebra, Robert P., Han, Bo W., Ashby, Meredith, Carvalho, Beatriz, Meijer, Gerrit A., Jimenez, Connie R., Fijneman, Remond JA

“…Introduction Early detection of colorectal cancer (CRC) and its precursor lesions (adenomas) is crucial to reduce mortality rates. The fecal immunochemical…”
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Abstract 1563: Stool proteomics reveals novel candidate biomarkers for colorectal cancer screening by Bosch, Linda JW, de Wit, Meike, Hiemstra, Annemieke C., Piersma, Sander, Pham, Thang, Oudgenoeg, Gideon, Scheffer, George, Mongera, Sandra, Komor, Malgorzata, Terhaar Sive Droste, Jochim, Oort, Frank A., van Turenhout, Sietze, Ben Larbi, Ilhame, Mulder, Chris JJ, Carvalho, Beatriz, Fijneman, Remond JA, Jimenez, Connie, Meijer, Gerrit A.

“…Introduction and objectives: Early detection of colorectal cancer (CRC) and its precursor lesions is an effective approach to reduce CRC mortality rates. The…”
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