Search Results - "Komoike, Yuta"

In vitro and in vivo studies of oxidative stress responses against acrylamide toxicity in zebrafish by Komoike, Yuta, Matsuoka, Masato

“…[Display omitted] •Acrylamide-induced stress response signaling pathways were explored in zebrafish.•Oxidative stress response-related genes were upregulated…”
Get full text

Experimental Evidence Shows Salubrinal, an eIF2α Dephosphorylation Inhibitor, Reduces Xenotoxicant-Induced Cellular Damage by Matsuoka, Masato, Komoike, Yuta

“…Accumulating evidence indicates that endoplasmic reticulum (ER) stress and the subsequent unfolded protein response (UPR) are involved in the pathogenesis of…”
Get full text

Intake of acrylamide at the dietary relevant concentration causes splenic toxicity in adult zebrafish by Komoike, Yuta, Nomura-Komoike, Kaori, Matsuoka, Masato

“…Acrylamide (AA) has recently been recognized as an immediate hazardous chemical compound owing to its various toxicities and unavoidable contamination of…”
Get full text

Developmental adverse effects of trace amounts of lead: Evaluation using zebrafish model by Komoike, Yuta, Matsuoka, Masato

“…Lead (Pb) is widely used as a raw material for various daily necessities in human civilization. However, Pb is a major toxicant and Pb poisoning has long been…”
Get full text

Exposure to tributyltin induces endoplasmic reticulum stress and the unfolded protein response in zebrafish by Komoike, Yuta, Matsuoka, Masato

“…•We examined whether exposure to TBT induces ER stress response in zebrafish.•Exposure to TBT in vivo induced organ-specific ER stress response.•Exposure to…”
Get full text

Effects of salubrinal on cadmium-induced apoptosis in HK-2 human renal proximal tubular cells by Komoike, Yuta, Inamura, Hisako, Matsuoka, Masato

“…Cadmium exposure is known to cause endoplasmic reticulum (ER) stress. In our current study, we examined the effects of salubrinal, a selective inhibitor of…”
Get full text

Germline gain-of-function mutations in RAF1 cause Noonan syndrome by Nishizawa, Tsutomu, Amo, Ryunosuke, Komoike, Yuta, Hirota, Hamao, Fujiwara, Yuko, Higashinakagawa, Toru, Katayama, Hiroshi, Razzaque, M Abdur, Furutani, Michiko, Momma, Kazuo, Muneuchi, Jun, Yagi, Hisato, Nakagawa, Masao, Mizuno, Katsumi, Tokuyama, Mika, Kamisago, Mitsuhiro, Matsuoka, Rumiko, Matsushima, Masaki

“…Noonan syndrome is characterized by short stature, facial dysmorphia and a wide spectrum of congenital heart defects. Mutations of PTPN11, KRAS and SOS1 in the…”
Get full text

Potential Teratogenicity of Methimazole: Exposure of Zebrafish Embryos to Methimazole Causes Similar Developmental Anomalies to Human Methimazole Embryopathy by Komoike, Yuta, Matsuoka, Masato, Kosaki, Kenjiro

“…While methimazole (MMI) is widely used in the therapy for hyperthyroidism, several groups have reported that maternal exposure to MMI results in a variety of…”
Get full text

Novel compound heterozygous mutations of POLR3A revealed by whole-exome sequencing in a patient with hypomyelination by Shimojima, Keiko, Shimada, Shino, Tamasaki, Akiko, Akaboshi, Shinjiro, Komoike, Yuta, Saito, Akira, Furukawa, Toru, Yamamoto, Toshiyuki

“…Abstract Objective Congenital white matter disorders are a heterogeneous group of hypomyelination disorders affecting the white matter of the brain. Recently,…”
Get full text

Single nucleotide variations in CLCN6 identified in patients with benign partial epilepsies in infancy and/or febrile seizures by Yamamoto, Toshiyuki, Shimojima, Keiko, Sangu, Noriko, Komoike, Yuta, Ishii, Atsushi, Abe, Shinpei, Yamashita, Shintaro, Imai, Katsumi, Kubota, Tetsuo, Fukasawa, Tatsuya, Okanishi, Tohru, Enoki, Hideo, Tanabe, Takuya, Saito, Akira, Furukawa, Toru, Shimizu, Toshiaki, Milligan, Carol J, Petrou, Steven, Heron, Sarah E, Dibbens, Leanne M, Hirose, Shinichi, Okumura, Akihisa

“…Nucleotide alterations in the gene encoding proline-rich transmembrane protein 2 (PRRT2) have been identified in most patients with benign partial epilepsies…”
Get full text

A functional analysis of GABARAP on 17p13.1 by knockdown zebrafish by Komoike, Yuta, Shimojima, Keiko, Liang, Jao-Shwann, Fujii, Hiroshi, Maegaki, Yoshihiro, Osawa, Makiko, Fujii, Sakiko, Higashinakagawa, Toru, Yamamoto, Toshiyuki

“…Array-based comparative genomic hybridization identified a 2.3-Mb microdeletion of 17p13.2p13.1 in a boy presenting with moderate mental retardation,…”
Get full text

Reduced PLP1 expression in induced pluripotent stem cells derived from a Pelizaeus-Merzbacher disease patient with a partial PLP1 duplication by Shimojima, Keiko, Inoue, Takahito, Imai, Yuki, Arai, Yasuhiro, Komoike, Yuta, Sugawara, Midori, Fujita, Takako, Ideguchi, Hiroshi, Yasumoto, Sawa, Kanno, Hitoshi, Hirose, Shinichi, Yamamoto, Toshiyuki

“…Pelizaeus-Merzbacher disease (PMD) is an X-linked recessive disorder characterized by dysmyelination of the central nervous system (CNS). We identified a rare…”
Get full text

Characterization of a novel KRAS mutation identified in Noonan syndrome by Razzaque, Md. Abdur, Komoike, Yuta, Nishizawa, Tsutomu, Inai, Kei, Furutani, Michiko, Higashinakagawa, Toru, Matsuoka, Rumiko

“…Noonan syndrome (NS) is the most common non‐chromosomal syndrome seen in children and is characterized by short stature, dysmorphic facial features, chest…”
Get full text

Endoplasmic reticulum stress-mediated neuronal apoptosis by acrylamide exposure by Komoike, Yuta, Matsuoka, Masato

“…Acrylamide (AA) is a well-known neurotoxic compound in humans and experimental animals. However, intracellular stress signaling pathways responsible for the…”
Get full text

Zebrafish gene knockdowns imply roles for human YWHAG in infantile spasms and cardiomegaly by Komoike, Yuta, Fujii, Katsunori, Nishimura, Akira, Hiraki, Yoko, Hayashidani, Michiko, Shimojima, Keiko, Nishizawa, Tsutomu, Higashi, Kouji, Yasukawa, Kumi, Saitsu, Hirotomo, Miyake, Noriko, Mizuguchi, Takeshi, Matsumoto, Naomichi, Osawa, Makiko, Kohno, Yoichi, Higashinakagawa, Toru, Yamamoto, Toshiyuki

“…Williams‐Beuren syndrome (WBS) is a neurodevelopmental disorder presenting with an elfin‐like face, supravalvular aortic stenosis, a specific…”
Get full text

Identification of a nuclear localization signal in mouse polycomb protein, M33 by Hirose, Sayako, Komoike, Yuta, Higashinakagawa, Toru

“…The mouse Polycomb group (PcG) protein M33 forms nuclear complexes with the products of other PcG members and maintains repressed states of developmentally…”
Get more information

Adaptive changes in TEF-1 gene expression during cold acclimation in the medaka by Yamasaki, Yukihiko, Komoike, Yuta, Higashinakagawa, Toru

“…How animals adaptively respond to a cold or hot environment has been questioned for a long time. Recently, with the aid of microarray analysis, various…”
Get more information

DNA Damage Response in Proliferating Müller Glia in the Mammalian Retina by Nomura-Komoike, Kaori, Saitoh, Fuminori, Komoike, Yuta, Fujieda, Hiroki

“…Müller glia, the principal glial cell type in the retina, have the potential to proliferate and regenerate neurons after retinal damage. However, unlike the…”
Get full text

Exposure to tributyltin induces endoplasmic reticulum stress and the unfolded protein response in zebrafish by KOMOIKE, Yuta, MATSUOKA, Masato

Get full text

Application of Zebrafish Model to Environmental Toxicology by Komoike, Yuta, Matsuoka, Masato

“…Recently, a tropical freshwater fish, the zebrafish, has been generally used as a useful model organism in various fields of life science worldwide. The…”
Get more information