Search Results - "Komissarov, Andrey A."

Effects of Extracellular DNA on Plasminogen Activation and Fibrinolysis by Komissarov, Andrey A., Florova, Galina, Idell, Steven

“…The increased levels of extracellular DNA found in a number of disorders involving dysregulation of the fibrinolytic system may affect interactions between…”
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Associations of D-Dimer on Admission and Clinical Features of COVID-19 Patients: A Systematic Review, Meta-Analysis, and Meta-Regression by Zhao, Runzhen, Su, Zhenlei, Komissarov, Andrey A, Liu, Shan-Lu, Yi, Guohua, Idell, Steven, Matthay, Michael A, Ji, Hong-Long

“…Dynamic D-dimer level is a key biomarker for the severity and mortality of COVID-19 (coronavirus disease 2019). How aberrant fibrinolysis influences the…”
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From Bedside to the Bench-A Call for Novel Approaches to Prognostic Evaluation and Treatment of Empyema by Karandashova, Sophia, Florova, Galina, Idell, Steven, Komissarov, Andrey A

“…Empyema, a severe complication of pneumonia, trauma, and surgery is characterized by fibrinopurulent effusions and loculations that can result in lung…”
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Intrapleural Fibrinolytic Interventions for Retained Hemothoraces in Rabbits by De Vera, Christian J, Jacob, Jincy, Sarva, Krishna, Christudas, Sunil, Emerine, Rebekah L, Florence, Jon M, Akiode, Oluwaseyi, Gorthy, Tanvi V, Tucker, Torry A, Singh, Karan P, Azghani, Ali O, Komissarov, Andrey A, Florova, Galina, Idell, Steven

“…Bleeding within the pleural space may result in persistent clot formation called retained hemothorax (RH). RH is prone to organization, which compromises…”
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A Novel Rabbit Model of Retained Hemothorax with Pleural Organization by De Vera, Christian J, Emerine, Rebekah L, Girard, René A, Sarva, Krishna, Jacob, Jincy, Azghani, Ali O, Florence, Jon M, Cook, Alan, Norwood, Scott, Singh, Karan P, Komissarov, Andrey A, Florova, Galina, Idell, Steven

“…Retained hemothorax (RH) is a commonly encountered and potentially severe complication of intrapleural bleeding that can organize with lung restriction. Early…”
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Targeting the PAI-1 Mechanism with a Small Peptide Increases the Efficacy of Alteplase in a Rabbit Model of Chronic Empyema by Florova, Galina, De Vera, Christian J, Emerine, Rebekah L, Girard, René A, Azghani, Ali O, Sarva, Krishna, Jacob, Jincy, Morris, Danna E, Chamiso, Mignote, Idell, Steven, Komissarov, Andrey A

“…The incidence of empyema is increasing and associated with a mortality rate of 20% in patients older than 65 years. Since 30% of patients with advanced empyema…”
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PAI-1 Drives Septation and Clinical Outcomes in Pleural Infection by Komissarov, Andrey A, Idell, Steven

“…Komissarov and Idell discuss the study by Bedawi and colleagues which demonstrated that PAI-1 is elevated in pleural fluids that were prospectively collected…”
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Precision targeting of the plasminogen activator inhibitor‐1 mechanism increases efficacy of fibrinolytic therapy in empyema by Florova, Galina, Girard, René A., Azghani, Ali O., Sarva, Krishna, Buchanan, Ann, Karandashova, Sophia, DeVera, Christian J., Morris, Danna, Chamiso, Mignote, Koenig, Kathleen, Cines, Douglas B., Idell, Steven, Komissarov, Andrey A.

“…Plasminogen activator inhibitor‐1 (PAI‐1) is an endogenous irreversible inhibitor of tissue‐type (tPA) and urokinase (uPA) plasminogen activators…”
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Lipoprotein receptor-related protein 1 regulates collagen 1 expression, proteolysis, and migration in human pleural mesothelial cells by Tucker, Torry A, Williams, LaTerrica, Koenig, Kathleen, Kothari, Hema, Komissarov, Andrey A, Florova, Galina, Mazar, Andrew P, Allen, Timothy C, Bdeir, Khalil, Mohan Rao, L Vijaya, Idell, Steven

“…The low-density lipoprotein receptor-related protein 1 (LRP-1) binds and can internalize a diverse group of ligands, including members of the fibrinolytic…”
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Perfluorochemical‐facilitated plasminogen activator delivery to the airways: A novel treatment for inhalational smoke‐induced acute lung injury by Wolfson, Marla R., Enkhbaatar, Perenlei, Fukuda, Satoshi, Nelson, Christina L., Williams, Robert O., Surasarang, Soraya Hengsawas, Sahakijpijarn, Sawittree, Calendo, Gennaro, Komissarov, Andrey A., Florova, Galina, Sarva, Krishna, Idell, Steven I., Shaffer, Thomas H.

“…Background Effective clinical management of airway clot and fibrinous cast formation of severe inhalational smoke‐induced acute lung injury (ISALI) is lacking…”
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The urokinase receptor supports tumorigenesis of human malignant pleural mesothelioma cells by Tucker, Torry A, Dean, Candice, Komissarov, Andrey A, Koenig, Kathy, Mazar, Andrew P, Pendurthi, Usha, Allen, Timothy, Idell, Steven

“…Malignant pleural mesothelioma (MPM) is a lethal neoplasm for which current therapy is unsatisfactory. The urokinase plasminogen activator receptor (uPAR) is…”
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Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator by Fukuda, Satoshi, Enkhbaatar, Perenlei, Nelson, Christina, Cox, Robert A., Wolfson, Marla R., Shaffer, Thomas H., Williams, Robert O., Surasarang, Soraya Hengsawas, Sawittree, Sahakijpijarn, Florova, Galina, Komissarov, Andrey A., Koenig, Kathleen, Sarva, Krishna, Ndetan, Harrison T., Singh, Karan P., Idell, Steven

“…Background Airway fibrin casts are clinically important complications of severe inhalational smoke-induced acute lung injury (ISIALI) for which reliable…”
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Fibrin turnover and pleural organization: bench to bedside by Komissarov, Andrey A, Rahman, Najib, Lee, Y C Gary, Florova, Galina, Shetty, Sreerama, Idell, Richard, Ikebe, Mitsuo, Das, Kumuda, Tucker, Torry A, Idell, Steven

“…Recent studies have shed new light on the role of the fibrinolytic system in the pathogenesis of pleural organization, including the mechanisms by which the…”
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Proteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: cutting edge and cleavage sites by Ji, Hong-Long, Zhao, Runzhen, Komissarov, Andrey A, Chang, Yongchang, Liu, Yongfeng, Matthay, Michael A

“…Plasminogen activator inhibitor 1 (PAI-1) level is extremely elevated in the edematous fluid of acutely injured lungs and pleurae. Elevated PAI-1 specifically…”
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Molecular mechanism of two nanobodies that inhibit PAI‐1 activity reveals a modulation at distinct stages of the PAI‐1/plasminogen activator interaction by Sillen, Machteld, Weeks, Stephen D., Zhou, Xiaohua, Komissarov, Andrey A., Florova, Galina, Idell, Steven, Strelkov, Sergei V., Declerck, Paul J.

“…Background Plasminogen activator inhibitor‐1 (PAI‐1), a key inhibitor of plasminogen activators (PAs) tissue‐type PA (tPA) and urokinase‐type PA (uPA) plays a…”
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Targeting of plasminogen activator inhibitor 1 improves fibrinolytic therapy for tetracycline-induced pleural injury in rabbits by Florova, Galina, Azghani, Ali, Karandashova, Sophia, Schaefer, Chris, Koenig, Kathleen, Stewart-Evans, Kris, Declerck, Paul J, Idell, Steven, Komissarov, Andrey A

“…Endogenous active plasminogen activator inhibitor 1 (PAI-1) was targeted in vivo with monoclonal antibodies (mAbs) that redirect its reaction with proteinases…”
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Dose dependency of outcomes of intrapleural fibrinolytic therapy in new rabbit empyema models by Komissarov, Andrey A, Florova, Galina, Azghani, Ali O, Buchanan, Ann, Boren, Jake, Allen, Timothy, Rahman, Najib M, Koenig, Kathleen, Chamiso, Mignote, Karandashova, Sophia, Henry, James, Idell, Steven

“…The incidence of empyema (EMP) is increasing worldwide; EMP generally occurs with pleural loculation and impaired drainage is often treated with intrapleural…”
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Targeting plasminogen activator inhibitor-1 in tetracycline-induced pleural injury in rabbits by Florova, Galina, Azghani, Ali O, Karandashova, Sophia, Schaefer, Chris, Yarovoi, Serge V, Declerck, Paul J, Cines, Douglas B, Idell, Steven, Komissarov, Andrey A

“…Elevated active plasminogen activator inhibitor-1 (PAI-1) has an adverse effect on the outcomes of intrapleural fibrinolytic therapy (IPFT) in…”
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Mechanisms of Conversion of Plasminogen Activator Inhibitor 1 from a Suicide Inhibitor to a Substrate by Monoclonal Antibodies by Komissarov, Andrey A, Declerck, Paul J, Shore, Joseph D

“…We have delineated two different reaction mechanisms of monoclonal antibodies (mAbs), MA-8H9D4 and either MA-55F4C12 or MA-33H1F7, that convert plasminogen…”
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Increased expression of plasminogen activator inhibitor-1 (PAI-1) is associated with depression and depressive phenotype in C57Bl/6J mice by Girard, René A., Chauhan, Prashant S., Tucker, Torry A., Allen, Tim, Kaur, Jaswinder, Jeffers, Ann, Koenig, Kathleen, Florova, Galina, Komissarov, Andrey A., Gaidenko, Tatiana A., Chamiso, Mignote B., Fowler, James, Morris, Danna E., Sarva, Krishna, Singh, Karan P., Idell, Steven, Idell, Richard D.

“…Plasminogen activator inhibitor 1 (PAI-1), which is elevated in numerous disease states, has been implicated as a stress-related protein involved in the…”
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