Search Results - "Komisarenko, S V"
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Mycobacterium tuberculosis antigens MPT63 and MPT83 increase phagocytic activity of murine peritoneal macrophages
Published in Ukrainian biochemical journal (01-09-2016)“…Macrophages (MΦ) are the most described and characterized target and host of mycobacteria. Like other cells of innate immunity MΦ have a wide range of receptor…”
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2
Scientists’ pursuit for SARS-COV-2 coronavirus: strategies against pandemic
Published in Ukrainian biochemical journal (24-12-2020)“…The SARS-CoV-2 coronavirus is the cause of the coronavirus disease 2019 (COVID-19), which in 2020 became pandemic and a global threat. As of January 10, 2021,…”
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FUNDAMENTAL DIFFERENCES BETWEEN NATURAL ANTIBODIES AND POLYREACTIVE IMMUNOGLOBULINS
Published in Ukrainian biochemical journal (01-09-2015)“…A problem of similarity and differences between so-called polyreactive immunoglobulins (PRIGs) and natural antibodies (NAbs), capable of cross-reacting with…”
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4
BIOLOGICAL AND IMMUNOCHEMICAL PROPERTIES OF POLYREACTIVE IMMUNOGLOBULINS
Published in Ukrainian biochemical journal (27-06-2015)“…A previously unknown phenomenon of acquired polyreactivity for serum immunoglobulins, which were subjected either to solutions of KSCN (3.0-5.0 M), low/high pH…”
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5
Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors
Published in Biochimie (01-11-2005)“…6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB) is a bifunctional enzyme, which is responsible for maintaining the cellular level of…”
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6
EFFECT OF DIPHTHERIA TOXIN T-DOMAIN ON ENDOSOMAL pH
Published in Ukrainian biochemical journal (01-07-2015)“…A key step in the mode of cytotoxic action of diphtheria toxin (DT) is the transfer of its catalytic domain (Cd) from endosomes into the cytosol. The main…”
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Age changes of human serum polyreactive immunoglobulins (PRIG) activity
Published in Ukrainian biochemical journal (01-09-2014)“…It has been determined that activity of serum polyreactive immunoglobulins (PRIG) changes with age in practically healthy people at the age from twenty five to…”
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Nobel prize winners Arvid Carlsson, Paul Greengard and Eric Kandel: the research of signal transduction in the nervous system
Published in Ukrainian biochemical journal (14-06-2023)“…For many decades, scientists have tried to unravel the mysteries of the nervous system – the complex phenomenon that receives messages, processes information,…”
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Interaction peculiarities of polyreactive immunoglobulins and various antigens
Published in Ukrainian biochemical journal (27-02-2014)“…The influence of twin 20, lysozyme and protamine on the capability of polyreactive immunoglobulins (PRIG) to attach to various antigens was investigated. Twin…”
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10
Unraveling the mystery of nitric oxide: Nobel prize winners Robert Furchgott, Louis Ignarro, and Ferid Murad
Published in Ukrainian biochemical journal (11-07-2022)“…In the 21st century, none of the scientists denies the determining role of the cardiovascular system and its central organ, the heart. The ongoing attempts to…”
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11
Standing on the shoulders of giants: James Watson, Francis Crick, Maurice Wilkins, Rosalind Franklin and the birth of molecular biology
Published in Ukrainian biochemical journal (10-09-2020)“…In the 20th century, DNA became a magnet, attracting representatives of various sciences. Prominent researchers competed among themselves to discover the…”
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12
A neoantigenic determinant in coiled coil region of human fibrin β-chain
Published in Thrombosis research (01-03-2009)“…Abstract Introduction The transformation of fibrinogen into fibrin by thrombin exposes neoantigenic determinants that are buried in fibrinogen. Fibrin-specific…”
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13
Immunological mechanisms of increased susceptibility to COVID-19 disease and its severe course in patients with diabetes mellitus type 2 and obesity
Published in Ukrainian biochemical journal (14-06-2023)“…In this review, we analyze and summarize literature data and the results of our own research related to the immunity status of patients with type 2 diabetes…”
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14
Effect of trifluoroethanol on antibodies binding properties
Published in Ukrainian biochemical journal (26-04-2023)“…The studies on the influence of organic co-solvents on the structure and function of antibodies are of key interest, especially in view of antibodies broad use…”
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15
Double Nobel prize winner: Frederick Sanger – the father of genomics
Published in Ukrainian biochemical journal (20-05-2021)“…This paper aims to outline briefly the main stages of Frederick Sanger’s scientific activity – the only person to have won two Nobel Prizes in Chemistry (1958,…”
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16
A legend in his own lifetime: double Nobel prize winner Linus Pauling
Published in Ukrainian biochemical journal (08-07-2021)“…Linus Pauling – a prominent American chemist, biochemist, chemical engineer, peace activist, author, and educator – was one of the scientists-humanists whose…”
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Nobel prize winner Erwin Schrodinger: the physicist, philosopher, and godfather of molecular biology and genetics
Published in Ukrainian biochemical journal (13-08-2020)“…The brilliant book “What is Life? The Physical Aspect of the Living Cell” authored by the prominent Nobel Prize-winning Austrian physicist Erwin Schrödinger…”
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Effect of the T-domain on intracellular transport of diphtheria toxin
Published in Ukrainian biochemical journal (01-05-2014)“…Subunit B of diphtheria toxin (DT), which consists of two domains: R (receptor-binding) and T (transmembrane), plays an important role in toxin-receptor…”
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19
Discovery of molecular and genetic mechanisms of cell cycle regulation: 2001 Nobel laureates leland Hartwell, Timothy Hunt and Paul Nurse
Published in Ukrainian biochemical journal (14-12-2023)“…Leland Hartwell, Paul Nurse and Timothy Hunt in 2001 were awarded the Nobel Prize for their discovery of molecular and genetic mechanisms of the cell cycle…”
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Prospects of genome editing using CRISPR/CAS or how to master genetic scissors. Nobel Prize in Chemistry 2020
Published in Ukrainian biochemical journal (22-02-2021)“…The Nobel Prize in Chemistry 2020 was awarded to two researchers in the field of molecular biology – the French Emmanuelle Charpentier, who now heads the Max…”
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