Search Results - "Komirishetty, Prashanth"

Melatonin prevents mitochondrial dysfunction and promotes neuroprotection by inducing autophagy during oxaliplatin‐evoked peripheral neuropathy by Areti, Aparna, Komirishetty, Prashanth, Akuthota, Manasaveena, Malik, Rayaz A., Kumar, Ashutosh

“…Oxaliplatin, an organoplatinum compound, is used in the treatment of colorectal cancer, but its clinical use can be limited due to the development of…”
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Rosmarinic Acid Mitigates Mitochondrial Dysfunction and Spinal Glial Activation in Oxaliplatin-induced Peripheral Neuropathy by Areti, Aparna, Komirishetty, Prashanth, Kalvala, Anil Kumar, Nellaiappan, Karthika, Kumar, Ashutosh

“…Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting complication which develops as a consequence of treatment with chemotherapeutic agents…”
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Neuroinflammation and Oxidative Stress in Diabetic Neuropathy: Futuristic Strategies Based on These Targets by Komirishetty, Prashanth, Areti, Aparna, Yerra, Veera Ganesh, Sandireddy, Reddemma, Kumar, Ashutosh

“…In Diabetes, the chronic hyperglycemia and associated complications affecting peripheral nerves are one of the most commonly occurring microvascular…”
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Dual Specificity Phosphatases Support Axon Plasticity and Viability by Chandrasekhar, Ambika, Komirishetty, Prashanth, Areti, Aparna, Krishnan, Anand, Zochodne, Douglas W.

“…In peripheral neuropathies, axonal degeneration (AxD) impairs the prognosis for recovery. Here, we describe a role for dual specificity phosphatases (DUSPs;…”
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Potential Therapeutic Benefits of Maintaining Mitochondrial Health in Peripheral Neuropathies by Areti, Aparna, Yerra, Veera Ganesh, Komirishetty, Prashanth, Kumar, Ashutosh

“…Background: Peripheral neuropathies are a group of diseases characterized by malfunctioning of peripheral nervous system. Neuropathic pain, one of the core…”
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PARP inhibition attenuates neuroinflammation and oxidative stress in chronic constriction injury induced peripheral neuropathy by Komirishetty, Prashanth, Areti, Aparna, Yerra, Veera Ganesh, PK, Ruby, Sharma, Shyam S., Gogoi, Ranadeep, Sistla, Ramakrishna, Kumar, Ashutosh

“…Peripheral nerve degeneration after nerve injury is accompanied with oxidative stress that may activate poly ADP-ribose polymerase (PARP, DNA repair enzyme)…”
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Poly(ADP-ribose) polymerase inhibition reveals a potential mechanism to promote neuroprotection and treat neuropathic pain by Komirishetty, Prashanth, Areti, Aparna, Gogoi, Ranadeep, Sistla, Ramakrishna, Kumar, Ashutosh

“…Neuropathic pain is triggered by the lesions to peripheral nerves which alter their structure and function. Neuroprotective approaches that limit the…”
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Survival of compromised adult sensory neurons involves macrovesicular formation by Krishnan, Anand, Areti, Aparna, Komirishetty, Prashanth, Chandrasekhar, Ambika, Cheng, Chu, Zochodne, Douglas W.

“…Adult neurons are recognized as post-mitotically arrested cells with limited regenerative potential. Given these restraints, it is perplexing how neurons…”
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Collaborative Roles for RAC1, ERM Proteins and PTEN During Adult Sensory Axon Regeneration by Areti, Aparna, Komirishetty, Prashanth, Zochodne, Douglas W

“…The role of local of growth cone (GC) manipulation in adult regenerative systems is largely unexplored despite substantial translational importance. Here we…”
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Carvedilol prevents functional deficits in peripheral nerve mitochondria of rats with oxaliplatin-evoked painful peripheral neuropathy by Areti, Aparna, Komirishetty, Prashanth, Kumar, Ashutosh

“…Oxaliplatin use as chemotherapeutic agent is frequently limited by cumulative neurotoxicity which may compromise quality of life. Reports relate this…”
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Combination strategy of PARP inhibitor with antioxidant prevent bioenergetic deficits and inflammatory changes in CCI-induced neuropathy by Komirishetty, Prashanth, Areti, Aparna, Gogoi, Ranadeep, Sistla, Ramakrishna, Kumar, Ashutosh

“…Neuropathic pain, a debilitating pain condition and the underlying pathogenic mechanisms are complex and interwoven amongst each other and still there is scant…”
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Morin Mitigates Chronic Constriction Injury (CCI)-Induced Peripheral Neuropathy by Inhibiting Oxidative Stress Induced PARP Over-Activation and Neuroinflammation by Komirishetty, Prashanth, Areti, Aparna, Sistla, Ramakrishna, Kumar, Ashutosh

“…Neuropathic pain is initiated or caused due to the primary lesion or dysfunction in the nervous system and is proposed to be linked to a cascade of events…”
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Combined PTEN Knockdown and Local Insulin in Chronic Experimental Diabetic Neuropathy by Pham, Vuong M, Komirishetty, Prashanth, Areti, Aparna, Poitras, Trevor, Thakor, Nitish, Zochodne, Douglas W

“…Diabetic polyneuropathy (DPN) renders progressive sensory neurodegeneration linked to hyperglycemia and its associated metabolopathy. We hypothesized that…”
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Manipulation of the Myc Interactome to Enhance Nerve Regeneration in a Murine Model by Poitras, Trevor M., Komirishetty, Prashanth, Areti, Aparna, Larouche, Matt, Krishnan, Anand, Chandrasekhar, Ambika, Munchrath, Easton, Zochodne, Douglas W.

“…Objective This study was undertaken to explore manipulation of the Myc protein interactome, members of an oncogene group, in enhancing the intrinsic growth of…”
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FeTMPyP a peroxynitrite decomposition catalyst ameliorated functional and behavioral deficits in chronic constriction injury induced neuropathic pain in rats by Komirishetty, Prashanth, Areti, Aparna, Arruri, Vijay Kumar, Sistla, Ramakrishna, Gogoi, Ranadeep, Kumar, Ashutosh

“…Neuropathic pain is a maladaptive pain phenotype that results from injury or damage to the somatosensory nervous system and is proposed to be linked to a…”
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Nrf2 and NF-κB modulation by Plumbagin attenuates functional, behavioural and biochemical deficits in rat model of neuropathic pain by Arruri, Vijay, Komirishetty, Prashanth, Areti, Aparna, Dungavath, Siva Kumar Naik, Kumar, Ashutosh

“…Plumbagin is known to exhibit a broad range of biological activities including anti-cancer, antimicrobial and has been widely used traditionally. Nuclear…”
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The Role of Protocadherin γ in Adult Sensory Neurons and Skin Reinnervation by Long, Rebecca M, Ong, Honyi, Wang, Wendy Xueyi, Komirishetty, Prashanth, Areti, Aparna, Chandrasekhar, Ambika, Larouche, Matt, Lefebvre, Julie L, Zochodne, Douglas W

“…The clustered protocadherins (cPcdhs) play a critical role in the patterning of several CNS axon and dendritic arbors, through regulation of homophilic self…”
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Boswellia ovalifoliolata abrogates ROS mediated NF-κB activation, causes apoptosis and chemosensitization in Triple Negative Breast Cancer cells by Thummuri, Dinesh, Jeengar, Manish Kumar, Shrivastava, Shweta, Areti, Aparna, Yerra, Veera Ganesh, Yamjala, Samyuktha, Komirishetty, Prashanth, Naidu, V.G.M, Kumar, Ashutosh, Sistla, Ramakrishna

“…Highlights • Boswellia ovalifoliolata (BL EthOH) showed cytotoxic activity against TNBC cells. • Cytotoxic activity of BL EthOH was found to be executed…”
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An evaluation of the CYP2D6 and CYP3A4 inhibition potential of metoprolol metabolites and their contribution to drug-drug and drug-herb interaction by LC-ESI/MS/MS by Borkar, Roshan M., Bhandi, Murali Mohan, Dubey, Ajay P., Ganga Reddy, V., Komirishetty, Prashanth, Nandekar, Prajwal P., Sangamwar, Abhay T., Kamal, Ahmed, Banerjee, Sanjay K., Srinivas, R.

“…The aim of the present study was to evaluate the contribution of metabolites to drug–drug interaction and drug–herb interaction using the inhibition of CYP2D6…”
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