Search Results - "Kombarova, T. I."

Biological properties and structure of the lipopolysaccharide of a vaccine strain of Francisella tularensis generated by inactivation of a quorum sensing system gene qseC by Mokrievich, A. N, Kondakova, A. N, Valade, E, Platonov, M. E, Vakhrameeva, G. M, Shaikhutdinova, R. Z, Mironova, R. I, Blaha, D, Bakhteeva, I. V, Titareva, G. M, Kravchenko, T. B, Kombarova, T. I, Vidal, D, Pavlov, V. M, Lindner, B, Dyatlov, I. A, Knirel, Yu. A

“…A knockout mutant with a deletion in a quorum sensing system gene qseC was generated from the vaccine strain Francisella tularensis 15 by site-directed…”
Get full text

Evaluation of the long-term memory T cell in mice after immunization with a live tularemia vaccine by Kartseva, A. S., Silkina, M. V., Titareva, G. M., Kombarova, T. I., Mironova, R. I., Firstova, V. V.

“…The vaccine strain F. tularensis 15 NIIEG induces long-lived cell-mediated immunity but exhibits a certain reactogenicity and genetic instability. Progress in…”
Get full text

Simulation of Bubonic Plague in BSL-2 Laboratory by Vagaiskaya, A. S., Trunyakova, A. S., Kombarova, T. I., Dentovskaya, S. V.

“…The causative agent of plague, Yersinia pestis , is classified as pathogenicity (hazard) group I agent, which means that the work with “wild type” strains…”
Get full text

SurA Is Required for Outer Membrane Biogenesis and Can Be Used as a New Molecular Target for Plague Therapy by Dentovskaya, S. V., Platonov, M. E., Shaikhutdinova, R. Z., Svetoch, T. E., Ivanov, S. A., Gapel’chenkova, T. V., Krasil’nikova, E. A., Trunyakova, A. S., Kombarova, T. I., Vagaiskaya, A. S., Lipatnikova, N. A., Mazurina, E. M., Kolombet, L. V., Anisimov, A. P.

“…The aim of this work was to determine the role of periplasmic chaperone SurA in the pathogenesis of bubonic and pneumonic plague. Yersinia pestis surA knockout…”
Get full text

Dynamics of Antibody Response to Yersinia pestis Proteins in Plague Affected Guinea Pigs by Gapel’chenkova, T. V., Shaikhutdinova, R. Z., Trunyakova, A. S., Svetoch, T. E., Kombarova, T. I., Platonov, M. E., Borzilov, A. I., Kopylov, P. Kh, Dentovskaya, S. V.

“…Designing of new means for the specific prevention of plague, especially protein subunit vaccines, is impossible without studying the role of individual…”
Get full text

Effect of 4-Hexylresorcinol on the Efficiency of Antibiotic Treatment of Experimental Sepsis Caused by Antibiotic-Resistant Klebsiella pneumoniae Strain in Mice by Shemyakin, I. G., Manzenyuk, O. Yu, El’-Registan, G. I., Firstova, V. V., Kombarova, T. I., Gneusheva, T. Yu, Kyazimov, E. I., Nikolaev, Yu. A.

“…High efficiency of a combined preparation including synergistic polymyxin B and 4-hexylresorcinol was shown for treatment of experimental sepsis caused by an…”
Get full text

Production and Characterization of Rat Monoclonal Antibodies against the PAL Antigen of Legionella spp by Zeninskaya, N. A., Riabko, A. K., Marin, M. A., Kombarova, T. I., Mitsevich, I. P., Yeruslanov, B. V., Firstova, V. V., Shemyakin, I. G.

“…The purpose of this work was to obtain genus-specific monoclonal antibodies against the Legionella spp. recombinant PAL protein, which will subsequently allow…”
Get full text

Characteristics of the Chromatographic Cleaning and Protectiveness of the LcrV Isoform of Yersinia pestis by Kopylov, P. Kh, Svetoch, T. E., Ivanov, S. A., Kombarova, T. I., Perovskaya, O. N., Titareva, G. M., Anisimov, A. P.

“…Electrophoretic, homogeneous, highly purified preparations of various isoforms of the immunodominant antigen V (LcrV protein) of Yersinia pestis have been…”
Get full text

Characterization of Immunogenic and Protective Properties of the Modified Variants of the Strain Francisella tularensis 15 NIIEG by Kartseva, A. S., Kalmantaeva, O. V., Silkina, M. V., Kombarova, T. I., Pavlov, V. M., Mokrievich, A. N., Firstova, V. V.

“…Francisella tularensis is an intracellular bacterium that causes tularemia. Progress in creating a safe and effective vaccine for the prevention of tularemia…”
Get full text

Virulence of HtpG+ and HtpG− strains of Yersinia pestis for Mice and Guinea Pigs by Krasil’nikova, E. A., Shaikhutdinova, R. Z., Svetoch, T. E., Platonov, M. E., Kombarova, T. I., Ivanov, S. A., Dentovskaya, S. V., Anisimov, A. P.

“…HtpG (high-temperature protein G) is a bacterial homologue of the highly conserved molecular chaperone Hsp90 of eukaryotes, which plays an important role in…”
Get full text

Features of humoral answer in experimental animal tularemia with different sensitivity to infection by Gorbatov, A. A., Titareva, G. M., Kombarova, T. I., Shaikhutdinova, R. Z., Kravchenko, T. V., Mironova, R. I., Bakhteeva, I. V., Aronova, N. V., Pavlovich, N. V., Mokrievich, A. N., Firstova, A. A.

“…Tularemia is an anthropozoonotic infection caused by Francisella tularensis. In clinical and sanitary-epidemiological practice, traditional diagnostics methods…”
Get full text

Selective Protective Potency of Yersinia pestis ΔnlpD Mutants by Dentovskaya, S V, Ivanov, S A, Kopylov, P Kh, Shaikhutdinova, R Z, Platonov, M E, Kombarova, T I, Gapel'chenkova, T V, Balakhonov, S V, Anisimov, A P

“…It has recently been shown that the NlpD lipoprotein is essential to Yersinia pestis virulence and that subcutaneous administration of the nlpD mutant could…”
Get full text

The Biological Properties of the Strain Francisella tularensis 15 NIIEG with Decreased Gene Expression sodB, Encoding Fe-Dependent Superoxide Dismutase by Sotnikova, M. A., Kravchenko, T. B., Bakhteeva, I. V., Mironova, R. I., Kombarova, T. I., Mokrievich, A. N., Pavlov, V. M.

“…Relevance. Superoxide anion has bactericidal properties and is also an important inducer of proinflammatory cytokines in macrophages. We have created F…”
Get full text

SELECTION OF PHYLOGENETICALLY CLOSELY-RELATED YERSINIA PESTIS STRAINS DIFFERING IN THEIR VIRULENCE FOR GUINEA PIGS by Anisimov, N. V., Kombarova, T. I., Platonov, M. E., Ivanov, S. A., Sukhova, M. A., Dentovskaya, S. V., Anisimov, A. P.

“…Genomic, transcriptome or (and) proteomic comparison of closely related virulent and avirulent microbial strains underlies the search for new pathogenicity…”
Get full text

Immunogenicity and Reactogenicity of Francisella tularensis Strain 15/23-1 recA - the Candidate for a New Live Tularemia Vaccine by Mokrievich, A. N., Titareva, G. M., Kombarova, T. I., Ganina, E. A., Kravchenko, T. B., Bakhteeva, I. V., Vakhrameeva, G. M., Mironova, R. I., Borzilov, A. I., Korobova, O. V., Pavlov, V. M., Dyatlov, I. A.

“…F. tularensis strain 15/23-1 recA is different from the vaccine strain F. tularensis line 15 NIIEG by lacking one from the two copies of iglC gene and recA…”
Get full text

Characteristics of Tularemia Agent Strains Isolated from Patients and Small Rodents during Tularemia Epidemic in Khanty-Mansiisk in 2013 by Pavlov, V. M., Kozlova, I. I., Mokrievich, A. N., Shutko, O. D., Timofeev, V. S., Mironova, R. I., Kuznetsova, T. S., Faizullina, N. M., Kudryavtseva, T. Yu, Kombarova, T. I., Dyatlov, I. A.

“…The paper contains the data on isolation of Francisella tularensis cultures from humans and rodents during tularemia epidemic in Khanty-Mansiisk in…”
Get full text

Construction and Investigation of the Variants of the Vaccine Strain Francisella tularensis Lacking iglC Genes. Communication 2 by Mokrievich, A. N., Vakhrameeva, G. M., Mironova, R. I., Kombarova, T. I., Bakhteeva, I. V., Titareva, G. M., Kravchenko, T. B., Dyatlov, I. A., Pavlov, V. M.

“…for BALB/c mice by an order while retaining protective properties. Strain Francisella tularensis 15 lacking two copies of the iglC gene cannot replicate in…”
Get full text

Construction and Investigation of the Vaccine Strain Francisella tularensis without iglC genes. Communication 1 by Mokrievich, A. N., Vakhrameeva, G. M., Mironova, R. I., Kombarova, T. I., Titareva, G. M., Kravchenko, T. B., Bakhteeva, I. V., Dyatlov, I. A., Pavlov, V. M.

“…Using site-specific mutagenesis constructed were the variants of the vaccine strain F. tularensis subsp. holarctica 15 with the deleted iglC genes. Identified…”
Get full text

Infectious Sensitivity of BALB/c Mice to Infestation with Photorhabdus asymbiotica and Photorhabdus temperata by Kirsheva, N. A., Ganina, E. A., Kombarova, T. I., Shaikhutdinova, R. Z., Dentovskaya, S. V., Anisimov, A. P.

“…) KOE). Identified are the patho-morphological changes in the organs of animals, inoculated with Photorhabdus spp. strains…”
Get full text

Immunobiological Properties of Francisella tularensis 15/10 Strain with Deleted recA Gene by Lapin, A. A., Mokrievich, A. N., Vakhrameeva, G. M., Kombarova, T. I., Bakhteeva, I. V., Dyatlov, I. A., Pavlov, V. M.

“…Deletion of recA gene in Francisella tularensis 15/10 genome leads to the increase in its sensitivity to ultraviolet irradiation, reduction of the homologous…”
Get full text