Search Results - "Komatsu, Koga"

Modulation of renal superoxide dismutase by telmisartan therapy in C57BL/6-Ins2(Akita) diabetic mice by Fujita, Hiroki, Fujishima, Hiromi, Morii, Tsukasa, Sakamoto, Takuya, Komatsu, Koga, Hosoba, Mihoko, Narita, Takuma, Takahashi, Keiko, Takahashi, Takamune, Yamada, Yuichiro

“…Renal superoxide excess, which is induced by an imbalance of the superoxide-producing enzyme NAD(P)H oxidase and the superoxide-scavenging enzyme superoxide…”
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Reduction of circulating superoxide dismutase activity in type 2 diabetic patients with microalbuminuria and its modulation by telmisartan therapy by Fujita, Hiroki, Sakamoto, Takuya, Komatsu, Koga, Fujishima, Hiromi, Morii, Tsukasa, Narita, Takuma, Takahashi, Takamune, Yamada, Yuichiro

“…Growing evidence indicates that oxidative stress induced by excessive superoxide has a central role in the pathogenesis of diabetic nephropathy (DN)…”
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Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in rats by Odashima, Masaru, Otaka, Michiro, Jin, Mario, Komatsu, Koga, Wada, Isao, Horikawa, Youhei, Matsuhashi, Tamotsu, Hatakeyama, Natsumi, Oyake, Jinko, Ohba, Reina, Watanabe, Sumio, Linden, Joel

“…AIM： To determine whether a specific adenosine A2A receptor agonist （ATL-146e） can ameliorate aspirin-induced gastric mucosal lesions in rats, and reduce…”
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Effect of cilostazol, a selective type-III phosphodiesterase inhibitor, on water-immersion stress-induced gastric mucosal injury in rats by Ohba, Reina, Otaka, Michiro, Odashima, Masaru, Jin, Mario, Komatsu, Koga, Konishi, Noriaki, Wada, Isao, Horikawa, Youhei, Matsuhashi, Tamotsu, Oyake, Jinko, Hatakeyama, Natsumi, Watanabe, Sumio

“…Cilostazol, a specific type-III phosphodiesterase inhibitor, is widely used for the treatment of ischemic symptoms of peripheral vascular disease. Recent…”
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Modulation of renal superoxide dismutase by telmisartan therapy in C57BL/6-Ins2Akita diabetic mice by Fujita, Hiroki, Fujishima, Hiromi, Morii, Tsukasa, Sakamoto, Takuya, Komatsu, Koga, Hosoba, Mihoko, Narita, Takuma, Takahashi, Keiko, Takahashi, Takamune, Yamada, Yuichiro

“…Renal superoxide excess, which is induced by an imbalance of the superoxide-producing enzyme NAD(P)H oxidase and the superoxide-scavenging enzyme superoxide…”
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Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells by Komatsu, Koga, Buchanan, F Gregory, Otaka, Michiro, Jin, Mario, Odashima, Masaru, Horikawa, Yohei, Watanabe, Sumio, Dubois, Raymond N

“…Constitutive activation of MEK1 (caMEK) can induce the oncogenic transformation of normal intestinal epithelial cells. To define the genetic changes that occur…”
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Small Intestinal Follicular Lymphoma with Multiple Tumor Formations Diagnosed by Double-Balloon Enteroscopy by Higuchi, Kazuyoshi, Komatsu, Koga, Wakamatsu, Hideki, Kawasaki, Hiromasa, Murata, Makoto, Miyazaki, Kenichi, Oikawa, Keisuke, Ohwada, Masanobu, Nanjo, Hiroshi, Otaka, Michiro, Watanabe, Sumio, Komatsu, Kanji

“…Follicular lymphoma of the small intestine remains relatively rare, especially in its early stage. Recently, double-balloon endoscopy has enabled observation…”
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Selective A2A adenosine agonist ATL-146e attenuates acute lethal liver injury in mice by Odashima, Masaru, Otaka, Michiro, Jin, Mario, Komatsu, Koga, Wada, Isao, Matsuhashi, Tamotsu, Horikawa, Youhei, Hatakeyama, Natsumi, Oyake, Jinko, Ohba, Reina, Linden, Joel, Watanabe, Sumio

“…D-Galactosamine (GalN)/lipopolysaccharide (LPS)-induced liver injury is an experimental model of fulminant hepatic failure in which tumor necrosis factor-alpha…”
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Protective effect of a novel rice extract against ethanol-induced gastric mucosal injury in rat by MATSUHASHI, Tamotsu, OTAKA, Michiro, WATANABE, Sumio, ODASHIMA, Masaru, JIN, Mario, KOMATSU, Koga, WADA, Isao, HORIKAWA, Youhei, OHBA, Reina, OYAKE, Jinko, HATAKEYAMA, Natsumi

“…The aim of this study was to investigate the protective action of rice extract on ethanol-induced mucosal damage in vivo and wound healing of epithelial cells…”
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MEK activation suppresses CPT11-induced apoptosis in rat intestinal epithelial cells through a COX-2-dependent mechanism by HORIKAWA, Youhei, OTAKA, Michiro, DUBOIS, Raymond N, WATANABE, Sumio, KOMATSU, Koga, JIN, Mario, ODASHIMA, Masaru, WADA, Isao, MATSUHASHI, Tamotsu, OHBA, Reina, OYAKE, Jinko, HATAKEYAMA, Natsumi

“…Resistance to chemotherapeutic agents is one of the distinct features of cancer cells. We evaluate the role of activated MEK-ERK signaling in…”
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DPP-4 inhibition with alogliptin on top of angiotensin II type 1 receptor blockade ameliorates albuminuria via up-regulation of SDF-1α in type 2 diabetic patients with incipient nephropathy by Hiroki Fujita, Hisanori Taniai, Hiroko Murayama, Haruyo Ohshiro, Hikaru Hayashi, Seiko Sato, Nyuko Kikuchi, Taiga Komatsu, Koga Komatsu, Kanji Komatsu, Takuma Narita, Yuichiro Yamada

“…[Abstract]. Dipeptidyl peptidase-4 (DPP-4) inhibitor is a new class of anti-diabetic drug which exerts its glucose-lowering action by suppressing the…”
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Rolipram, a specific type IV phosphodiesterase inhibitor, ameliorates aspirin-induced gastric mucosal injury in rats by ODASHIMA, Masaru, OTAKA, Michiro, HATAKEYAMA, Nastumi, WATANABE, Sumio, JIN, Mario, KOMATSU, Koga, KONISHI, Noriaki, WADA, Isao, HORIKAWA, Youhei, MATSUHASHI, Tamotsu, OHBA, Reina, OYAKE, Jinko

“…Inhibition of type IV phosphodiesterase (PDE IV) activity reduces the production of various proinflammatory cytokine and suppresses neutrophil activation…”
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Cre-loxP-mediated bax gene activation reduces growth rate and increases sensitivity to chemotherapeutic agents in human gastric cancer cells by Komatsu, K, Suzuki, S, Shimosegawa, T, Miyazaki, J I, Toyota, T

“…Dysregulation of apoptosis may be closely related to the development of cancer and its chemoresistance. Overexpression of Bax, an inducer of apoptosis, has led…”
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DPP-4 inhibition with alogliptin on top of angiotensin II type 1 receptor blockade ameliorates albuminuria via up-regulation of SDF-1α in type 2 diabetic patients with incipient nephropathy by Fujita, Hiroki, Taniai, Hisanori, Murayama, Hiroko, Ohshiro, Haruyo, Hayashi, Hikaru, Sato, Seiko, Kikuchi, Nyuko, Komatsu, Taiga, Komatsu, Koga, Komatsu, Kanji, Narita, Takuma, Yamada, Yuichiro

“…Dipeptidyl peptidase-4 (DPP-4) inhibitor is a new class of anti-diabetic drug which exerts its glucose-lowering action by suppressing the degradation of a gut…”
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Erythropoietic protoporphyria with severe liver dysfunction and acute pancreatitis by Komatsu, K, Shimosegawa, T, Uchi, M, Maruhama, Y, Toyota, T

“…A case of erythropoietic protoporphyria associated with severe hepatic dysfunction and acute pancreatitis is reported. The patient, a 33-year-old man, was…”
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Paradoxical Progression of Biliary Strictures against Recovery of Biochemical Parameters under Ursodeoxycholic Acid Treatment in a Case of Primary Sclerosing Cholangitis with Ulcerative Colitis by KOMATSU, Koga, SHJMOSEGAWA, Tooru, KIKUCHI, Satoru, UCHI, Midori, MARUHAMA, Yoshisuke, KISARA, Norihiro, UENO, Yoshiyuki, TOYOTA, Takayoshi

“…Ursodeoxycholic acid (UDCA) treatment-for primary sclerosing cholangitis (PSC) has been considered a rational therapy, though its effectiveness in the clinical…”
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Over-expression of 70-kDa heat shock protein confers protection against monochloramine-induced gastric mucosal cell injury by Oyake, Jinko, Otaka, Michiro, Matsuhashi, Tamotsu, Jin, Mario, Odashima, Masaru, Komatsu, Koga, Wada, Isao, Horikawa, Youhei, Ohba, Reina, Hatakeyama, Natsumi, Itoh, Hideaki, Watanabe, Sumio

“…The major heat shock protein, HSP70, is known to be involved in cytoprotection against environmental stresses mediated by their function as a “molecular…”
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Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats—Correlation of HSP72 expression with mucosal protection by Wada, Isao, Otaka, Michiro, Jin, Mario, Odashima, Masaru, Komatsu, Koga, Konishi, Noriaki, Matsuhashi, Tamotsu, Horikawa, Youhei, Ohba, Reina, Itoh, Hideaki, Watanabe, Sumio

“…The real mechanism of adaptive cytoprotection in the gastric mucosa is not well established. In the present study, we investigated the effect of acid…”
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Systemic stress increases serum leptin level by Konishi, Noriaki, Otaka, Michiro, Odashima, Masaru, Jin, Mario, Wada, Isao, Komatsu, Koga, Sato, Toshihiro, Kato, Sayuri, Matsuhashi, Tamotsu, Watanabe, Sumio

“…Background and Aim:  Leptin, the product of the obese (ob) gene, is a circulating peptide mainly synthesized by adipocytes. Leptin inhibits food intake and…”
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Oncogenic Potential of MEK1 in Rat Intestinal Epithelial Cells Is Mediated via Cyclooxygenase-2 by Komatsu, Koga, Buchanan, F. Gregory, Katkuri, Sharada, Morrow, Jason D., Inoue, Hiroyasu, Otaka, Michiro, Watanabe, Sumio, DuBois, Raymond N.

“…Background & Aims: The mitogen-activated protein kinase/extracellular signal-regulated protein kinase kinase (MEK) pathway plays an important role in the…”
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