Search Results - "Komatsu, Katsuichiro"
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Novel Antifungal Compound Z-705 Specifically Inhibits Protein Kinase C of Filamentous Fungi
Published in Applied and environmental microbiology (15-05-2019)“…The cell wall integrity signaling (CWIS) pathway is involved in fungal cell wall biogenesis. This pathway is composed of sensor proteins, protein kinase C…”
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2
Inhibition of bacterial undecaprenyl pyrophosphate synthase by small fungal molecules
Published in Journal of antibiotics (01-11-2016)“…Viridicatumtoxin and spirohexaline, small fungal molecules with a tetracyclic scaffold and an additional spirobicyclic ring in common, were found to inhibit…”
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3
Evaluation of the third solvent clusters fitting procedure for the prediction of protein-protein interactions based on the results at the CAPRI blind docking study
Published in Proteins, structure, function, and bioinformatics (01-07-2003)“…To predict protein–protein interactions, rough or coarse handling for the induced fit problem is proposed. Our method involves the overlap of two hydrophobic…”
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FAMSBASE: Modeling Database of 161 Genomes
Published in Genome Informatics (2003)Get full text
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Regioselective Synthesis of 14-Membered Biaryl Ethers : Total Synthesis of RA-VII and Deoxybouvardin
Published in Chemical & pharmaceutical bulletin (1995)“…In order to obtain a key compound (22a") for synthesis of RA-VII (1) and deoxybouvardin (2), construction of the 14-membered ring system was performed by means…”
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6
Electrostatic complementarities between guest ligands and host enzymes
Published in Journal of the Physical Society of Japan (01-01-1985)“…A method is described for visualizing electrostatic complementarity between a guest ligand and a host enzyme by using molecular graphics and drawing a…”
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van der Waals Volume and the Related Parameters for Hydrophobicity in Structure-Activity Studies
Published in Chemical & pharmaceutical bulletin (1976)“…The correlations of Hansch's hydrophobic constant (log P) with van der Waals volume (Vw) and with van der Waals surface area (Aw) were studied using 60…”
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Estimation of Hydrophobicity Based on the Solvent-Accessible Surface Area of Molecules
Published in Chemical & pharmaceutical bulletin (01-01-1985)“…A novel method of estimating Hansch's hydrophobic constant (log P) by making use of the solvent-accessible surface area (SA) with correction for the…”
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Searching for protein-protein interaction sites and docking by the methods of molecular dynamics, grid scoring, and the pairwise interaction potential of amino acid residues
Published in Proteins, structure, function, and bioinformatics (01-08-2005)“…In CAPRI Rounds 1 and 2, we assumed that because there are many ionic charges that weaken electrostatic interaction forces in living cells, the hydrophobic…”
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ELECTROSTATIC FORCES IN THE INHIBITION OF DIHYDROFOLATE REDUCTASE BY METHOTREXATE. A FIELD POTENTIAL STUDY
Published in Chemical & pharmaceutical bulletin (01-01-1984)“…Methotrexate (MTX) is a high affinity inhibitor of the reaction catalyzed by dihydrofolate reductase (DHFR) from Lactobacillus casei. MTX is a folic acid…”
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Electrostatic Interaction Energy and Solvent Accessibility in the Methotrexate-Reduced Nicotinamide Adenine Dinucleotide Phosphate-Dihydrofolate Reductase Ternary Complex
Published in Chemical & pharmaceutical bulletin (1987)“…The electrostatic interaction energies among dihydrofolate reductase (DHFR), coenzyme reduced nicotinamide adenine dinucleotide phosphate (NADPH) and…”
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12
AQUATIC TOXICITY. : A PREDICTIVE STRUCTURE-ACTIVITY MODEL
Published in Chemical & pharmaceutical bulletin (01-01-1985)“…A quantitative structure-toxicity model has been developed for the estimation of aquatic toxicity ratings for a wide variety of organic chemicals using the…”
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Adaptive Least-Squares Classification applied to Structure-Activity Correlation of Antitumor Mitomycin Derivatives
Published in Chemical & pharmaceutical bulletin (1977)“…An adaptive least-squares (ALS) classification which is capable of relating structure to activity rating of chemical compounds has been developed. The ALS…”
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14
Regioselective Synthesis of 14-Membered Biaryl Ethers
Published in Chemical & pharmaceutical bulletin (01-08-1995)“…In order to obtain a key compound (22a") for synthesis of RA-VII (1) and deoxybouvardin (2), construction of the 14-membered ring system was performed by means…”
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15
Adaptive least-squares method applied to structure-activity correlation of hypotensive N-alkyl-N''-cyano-N'-pyridylguanidines
Published in Journal of medicinal chemistry (01-01-1980)“…A method using an adaptive least-squares (ALS) technique has been developed for the discrimination of ordered categorical data. The method (ALS method) has the…”
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