Search Results - "Komarov, Alexander G."

Semisynthetic K⁺ channels show that the constricted conformation of the selectivity filter is not the C-type inactivated state by Devaraneni, Prasanna K., Komarov, Alexander G., Costantino, Corey A., Devereaux, Jordan J., Matulef, Kimberly, Valiyaveetil, Francis I.

“…C-type inactivation of K ⁺ channels plays a key role in modulating cellular excitability. During C-type inactivation, the selectivity filter of a K ⁺ channel…”
Get full text

Using protein backbone mutagenesis to dissect the link between ion occupancy and C-type inactivation in K⁺ channels by Matulef, Kimberly, Komarov, Alexander G., Costantino, Corey A., Valiyaveetil, Francis I.

“…K ⁺ channels distinguish K ⁺ from Na ⁺ in the selectivity filter, which consists of four ion-binding sites (S1–S4, extracellular to intracellular) that are…”
Get full text

The Physiological Properties of a Novel Family of VDAC-Like Proteins from Drosophila melanogaster by Komarov, Alexander G., Graham, Brett H., Craigen, William J., Colombini, Marco

“…VDAC, a major protein of the mitochondrial outer membrane, forms voltage-dependent, anion-selective channels permeable to most metabolites. Although multiple…”
Get full text

Modular Strategy for the Semisynthesis of a K+ Channel: Investigating Interactions of the Pore Helix by Komarov, Alexander G, Linn, Kellie M, Devereaux, Jordan J, Valiyaveetil, Francis I

“…Chemical synthesis is a powerful method for precise modification of the structural and electronic properties of proteins. The difficulties in the synthesis and…”
Get full text

Rectification Properties and pH-Dependent Selectivity of Meningococcal Class 1 Porin by Cervera, Javier, Komarov, Alexander G., Aguilella, Vicente M.

“…We studied the current rectification properties and selectivity of class 1 porin (PorA) from Neisseria meningitidis (strain H44/76 Δ3Δ4) reconstituted in…”
Get full text

New Insights into the Mechanism of Permeation through Large Channels by Komarov, Alexander G., Deng, Defeng, Craigen, William J., Colombini, Marco

“…The mitochondrial channel, VDAC, regulates metabolite flux across the outer membrane. The open conformation has a higher conductance and anionic selectivity,…”
Get full text

Engineering K+ channels using semisynthesis by Komarov, Alexander G, Costantino, Corey A, Valiyaveetil, Francis I

“…Potassium channels conduct K(+) ions selectively and at very high rates. Central to the function of K(+) channels is a structural unit called the selectivity…”
Get more information

Protein Backbone Mutagenesis Reveals a Novel Link between Ion Occupancy and C-type Inactivation in K+ Channels by Matulef, Kimberly, Komarov, Alexander G., Valiyaveetil, Francis I.

Get full text

Semisynthesis of K+ channels by Komarov, Alexander G, Linn, Kellie M, Devereaux, Jordan J, Valiyaveetil, Francis I

“…The ability to selectively conduct K(+) ions is central to the function of K(+) channels. Selection for K(+) and rejection of Na(+) takes place in a conserved…”
Get more information

A modular strategy for the semi-synthesis of a K+ channel: Investigating interactions of the pore helix by Komarov, Alexander G., Linn, Kellie M., Devereaux, Jordan J., Valiyaveetil, Francis I.

“…Chemical synthesis is a powerful method for precise modification of the structural and electronic properties of proteins. The difficulties in the synthesis and…”
Get full text

Mitochondrial VDAC and bacterial PorA /C1: Ion permeation and selectivity by Komarov, Alexander G

“…VDAC and PorA/C1 are large diameter channels with properties reminiscent of those found in narrow channels. VDAC, located in the mitochondrial outer membrane,…”
Get full text