Search Results - "Komano, Jun"

Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping by Gee, Peter, Lung, Mandy S. Y., Okuzaki, Yuya, Sasakawa, Noriko, Iguchi, Takahiro, Makita, Yukimasa, Hozumi, Hiroyuki, Miura, Yasutomo, Yang, Lucy F., Iwasaki, Mio, Wang, Xiou H., Waller, Matthew A., Shirai, Nanako, Abe, Yasuko O., Fujita, Yoko, Watanabe, Kei, Kagita, Akihiro, Iwabuchi, Kumiko A., Yasuda, Masahiko, Xu, Huaigeng, Noda, Takeshi, Komano, Jun, Sakurai, Hidetoshi, Inukai, Naoto, Hotta, Akitsu

“…Prolonged expression of the CRISPR-Cas9 nuclease and gRNA from viral vectors may cause off-target mutagenesis and immunogenicity. Thus, a transient delivery…”
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The Role of Human Mobility Flow in the Region-to-Region Spread of Respiratory Syncytial Virus Infection among Infants: An Infographic Analysis by Sasaki, Hide, Seoka, Ryo, Yagi, Mayuko, Komano, Jun

“…The region-to-region spread of human infectious diseases is considered to be dependent on the human mobility flow (HMF). However, it has been hard to obtain…”
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Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1 by Saitoh, Tatsuya, Komano, Jun, Saitoh, Yasunori, Misawa, Takuma, Takahama, Michihiro, Kozaki, Tatsuya, Uehata, Takuya, Iwasaki, Hidenori, Omori, Hiroko, Yamaoka, Shoji, Yamamoto, Naoki, Akira, Shizuo

“…Neutrophils contribute to pathogen clearance by producing neutrophil extracellular traps (NETs), which are genomic DNA-based net-like structures that capture…”
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Development and Crosslinking Properties of Psoralen-Conjugated Triplex-Forming Oligonucleotides as Antigene Tools Targeting Genome DNA by Mikame, Yu, Eshima, Honoka, Toyama, Haruki, Nakao, Juki, Matsuo, Misaki, Yamamoto, Tsuyoshi, Hari, Yoshiyuki, Komano, Jun A, Yamayoshi, Asako

“…Psoralen-conjugated triplex-forming oligonucleotides (Ps-TFOs) have been utilized for genome editing and anti-gene experiments for over thirty years. However,…”
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Development of 7SK snRNA Mimics That Inhibit HIV Transcription by Yamayoshi, Asako, Fukumoto, Hiroyuki, Hayashi, Rie, Kishimoto, Kyosuke, Kobori, Akio, Koyanagi, Yoshio, Komano, Jun A., Murakami, Akira

“…The 332‐nucleotide small nuclear RNA (snRNA) 7SK is a highly conserved non‐coding RNA that regulates transcriptional elongation. By binding with positive…”
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Current prevention and control of health care-associated infections in long-term care facilities for the elderly in Japan by Kariya, Naoko, Sakon, Naomi, Komano, Jun, Tomono, Kazunori, Iso, Hiroyasu

“…Residents of long-term care facilities for the elderly are vulnerable to health care-associated infections. However, compared to medical institutions,…”
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Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response by Kozaki, Tatsuya, Komano, Jun, Kanbayashi, Daiki, Takahama, Michihiro, Misawa, Takuma, Satoh, Takashi, Takeuchi, Osamu, Kawai, Taro, Shimizu, Shigeomi, Matsuura, Yoshiharu, Akira, Shizuo, Saitoh, Tatsuya

“…The innate immune system senses RNA viruses by pattern recognition receptors (PRRs) and protects the host from virus infection. PRRs mediate the production of…”
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Bejel, a Nonvenereal Treponematosis, among Men Who Have Sex with Men, Japan by Kawahata, Takuya, Kojima, Yoko, Furubayashi, Keiichi, Shinohara, Koh, Shimizu, Tsunehiro, Komano, Jun, Mori, Haruyo, Motomura, Kazushi

“…Bejel, an endemic treponematosis caused by infection with Treponema pallidum subspecies endemicum, has not been reported in eastern Asia and the Pacific…”
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Regional and temporal genotype profiling of Clostridioides difficile in a multi-institutional study in Japan by Sagisaka, Yusaku, Ishibashi, Miyako, Hosokawa, Daisuke, Nakagawa, Hikaru, Yonogi, Shinya, Minami, Kenta, Suzuki, Youichi, Ogawa, Taku, Ukimura, Akira, Nakano, Takashi, Komano, Jun

“…Clostridioides difficile , a cause of healthcare-associated infections, poses a significant global health threat. This multi-institutional retrospective study…”
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Impact of Genotype-Specific Herd Immunity on the Circulatory Dynamism of Norovirus: A 10-Year Longitudinal Study of Viral Acute Gastroenteritis by Sakon, Naomi, Yamazaki, Kenji, Nakata, Keiko, Kanbayashi, Daiki, Yoda, Tomoko, Mantani, Masanobu, Kase, Tetsuo, Takahashi, Kazuo, Komano, Jun

“…Human norovirus is a major cause of viral acute gastroenteritis worldwide. However, the transition of endemic norovirus genotypes remains poorly understood…”
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Relationship between biochemical markers and measles viral load in patients with immunologically naive cases and secondary vaccine failure: LDH is one of the potential auxiliary indicators for secondary vaccine failure by Kurata, Takako, Kanbayashi, Daiki, Komano, Jun, Motomura, Kazushi

“…This study investigated the correlation between biochemical markers and viral load among 38 measles cases, including 15 immunologically naive patients and 23…”
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VuuB and IutB reduce ferric-vulnibactin in Vibrio vulnificus M2799 by Okai, Naoko, Miyamoto, Katsushiro, Tomoo, Koji, Tsuchiya, Takahiro, Komano, Jun, Tanabe, Tomotaka, Funahashi, Tatsuya, Tsujibo, Hiroshi

“…Vibrio vulnificus , a pathogenic bacterium that causes serious infections in humans, requires iron for growth. Clinical isolate, V. vulnificus M2799, secretes…”
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Clinical perspectives of Treponema pallidum subsp. Endemicum infection in adults, particularly men who have sex with men in the Kansai area, Japan: A case series by Shinohara, Koh, Furubayashi, Keiichi, Kojima, Yoko, Mori, Haruyo, Komano, Jun, Kawahata, Takuya

“…Bejel, caused by Treponema pallidum subsp. Endemicum (TEN), is a locally transmitted disease among children and juveniles in hot and dry regions. The number of…”
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Global Spread of Norovirus GII.17 Kawasaki 308, 2014-2016 by Chan, Martin C W, Hu, Yunwen, Chen, Haili, Podkolzin, Alexander T, Zaytseva, Ekaterina V, Komano, Jun, Sakon, Naomi, Poovorawan, Yong, Vongpunsawad, Sompong, Thanusuwannasak, Thanundorn, Hewitt, Joanne, Croucher, Dawn, Collins, Nikail, Vinjé, Jan, Pang, Xiaoli L, Lee, Bonita E, de Graaf, Miranda, van Beek, Janko, Vennema, Harry, Koopmans, Marion P G, Niendorf, Sandra, Poljsak-Prijatelj, Mateja, Steyer, Andrej, White, Peter A, Lun, Jennifer H, Mans, Janet, Hung, Tin-Nok, Kwok, Kirsty, Cheung, Kelton, Lee, Nelson, Chan, Paul K S

“…Analysis of complete capsid sequences of the emerging norovirus GII.17 Kawasaki 308 from 13 countries demonstrated that they originated from a single haplotype…”
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Antiviral activity of acid beta-glucosidase 1 on enterovirus 71, a causative agent of hand, foot and mouth disease by Nakata, Keiko, Takeda, Satoshi, Tanaka, Atsushi, Kwang, Jimmy, Komano, Jun

“…Enterovirus 71 (EV71) is a causative agent of hand, foot and mouth disease (HFMD). EV71 causes fever, rash, diarrhoea and, in some cases, acute…”
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Epstein-Barr Virus Provides a Survival Factor to Burkitt's Lymphomas by Kennedy, Gregory, Komano, Jun, Sugden, Bill

“…Epstein-Barr virus (EBV) has been causally associated with at least five human malignancies. The exact contributions made by EBV to these cancers remain…”
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Zinc-finger antiviral protein mediates retinoic acid inducible gene I—like receptor-independent antiviral response to murine leukemia virus by Lee, Hanna, Komano, Jun, Saitoh, Yasunori, Yamaoka, Shoji, Kozaki, Tatsuya, Misawa, Takuma, Takahama, Michihiro, Satoh, Takashi, Takeuchi, Osamu, Yamamoto, Naoki, Matsuura, Yoshiharu, Saitoh, Tatsuya, Akira, Shizuo

“…When host cells are infected by an RNA virus, pattern-recognition receptors (PRRs) recognize the viral RNA and induce the antiviral innate immunity. Toll-like…”
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Foodborne Outbreaks Caused by Human Norovirus GII.P17-GII.17-Contaminated Nori, Japan, 2017 by Sakon, Naomi, Sadamasu, Kenji, Shinkai, Takayuki, Hamajima, Yousuke, Yoshitomi, Hideaki, Matsushima, Yuki, Takada, Rika, Terasoma, Fumio, Nakamura, Asako, Komano, Jun, Nagasawa, Koo, Shimizu, Hideaki, Katayama, Kazuhiko, Kimura, Hirokazu

“…Seven foodborne norovirus outbreaks attributable to the GII.P17-GII.17 strain were reported across Japan in 2017, causing illness in a total of 2,094 persons…”
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A novel cell-based high throughput assay to determine neutralizing antibody titers against circulating strains of rubella virus by Kanbayashi, Daiki, Kurata, Takako, Takahashi, Kazuo, Kase, Tetsuo, Komano, Jun

“…•A novel high throughput neutralization assay against rubella virus was established.•Correlations between IgG, HI, and neutralization antibody titers were…”
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Cytokine signatures of transformed B cells with distinct Epstein–Barr virus latencies as a potential diagnostic tool for B cell lymphoma by Miyauchi, Kosuke, Urano, Emiko, Yoshiyama, Hironori, Komano, Jun

“…Immunocompromised individuals, including those infected with human immunodeficiency virus (HIV), are at increased risk of Epstein–Barr virus (EBV)‐associated…”
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