Search Results - "Komáromy, András M."

Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement by Cideciyan, Artur V., Jacobson, Samuel G., Beltran, William A., Sumaroka, Alexander, Swider, Malgorzata, Iwabe, Simone, Roman, Alejandro J., Olivares, Melani B., Schwartz, Sharon B., Komáromy, András M., Hauswirth, William W., Aguirre, Gustavo D.

“…Leber congenital amaurosis (LCA) associated with retinal pigment epithelium-specific protein 65 kDa (RPE65) mutations is a severe hereditary blindness…”
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Long-Term Structural Outcomes of Late-Stage RPE65 Gene Therapy by Gardiner, Kristin L., Cideciyan, Artur V., Swider, Malgorzata, Dufour, Valérie L., Sumaroka, Alexander, Komáromy, András M., Hauswirth, William W., Iwabe, Simone, Jacobson, Samuel G., Beltran, William A., Aguirre, Gustavo D.

“…The form of hereditary childhood blindness Leber congenital amaurosis (LCA) caused by biallelic RPE65 mutations is considered treatable with a gene therapy…”
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Ocular injury progression and cornea histopathology from chloropicrin vapor exposure: Relevant clinical biomarkers in mice by Ebenezar, Okoyeocha OM, Roney, Andrew, Goswami, Dinesh G., Petrash, J. Mark, Sledge, Dodd, Komáromy, András M., Liby, Karen T., Tewari-Singh, Neera

“…Ocular tissue is highly sensitive to chemical exposures. Chloropicrin (CP), a choking agent employed during World War I and currently a popular pesticide and…”
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Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects by Guziewicz, Karina E, Zangerl, Barbara, Komáromy, András M, Iwabe, Simone, Chiodo, Vincent A, Boye, Sanford L, Hauswirth, William W, Beltran, William A, Aguirre, Gustavo D

“…Mutations in the BEST1 gene constitute an underlying cause of juvenile macular dystrophies, a group of retinal disorders commonly referred to as…”
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Efficacy of the positioning system when measuring canine intraocular pressures with the Reichert® Tono‐Vera® Vet rebound tonometer by Cabble, Ava, Bajric, Shayla, Kapeller, Lydia E., Harman, Christine D., Jacobson, Amanda L., Palanivel, Hemalatha, Taylor, David A., Komáromy, András M.

“…Objective To compare intraocular pressure (IOP) measurements in dogs taken with the Reichert® Tono‐Vera® Vet rebound tonometer with and without the automatic…”
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Comparison of three rebound tonometers in normal and glaucomatous dogs by Hodgson, Kimberly J., Harman, Christine D., Bajric, Shayla, Cabble, Ava, Anderson, Amanda L., Palanivel, Hemalatha, Taylor, David A., Komáromy, András M.

“…Objective The objectives of the study were to compare intraocular pressure (IOP) readings across a wide range and obtained via three rebound tonometers in…”
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A novel missense mutation in ADAMTS10 in Norwegian Elkhound primary glaucoma by Ahonen, Saija J, Kaukonen, Maria, Nussdorfer, Forrest D, Harman, Christine D, Komáromy, András M, Lohi, Hannes

“…Primary glaucoma is one of the most common causes of irreversible blindness both in humans and in dogs. Glaucoma is an optic neuropathy affecting the retinal…”
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Iris angiography in ADAMTS10 mutant dogs with open‐angle glaucoma (ADAMTS10‐OAG) by Pytak, Richard A., Pirie, Christopher G., Harman, Christine D., Anderson, Amanda L., Yao, Shay Xuejing, Komáromy, András M.

“…Objective To evaluate anterior segment angiographic findings in hypertensive ADAMTS10‐open‐angle glaucoma (ADAMTS10‐OAG) eyes as compared to normotensive…”
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A Novel Genome-Wide Association Study Approach Using Genotyping by Exome Sequencing Leads to the Identification of a Primary Open Angle Glaucoma Associated Inversion Disrupting ADAMTS17 by Forman, Oliver P, Pettitt, Louise, Komáromy, András M, Bedford, Peter, Mellersh, Cathryn

“…Closed breeding populations in the dog in conjunction with advances in gene mapping and sequencing techniques facilitate mapping of autosomal recessive…”
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Assessment of Early Glaucomatous Optic Neuropathy in the Dog by Spectral Domain Optical Coherence Tomography (SD-OCT) by Oh, Annie, Harman, Christine D, Koehl, Kristin L, Huang, Jiayan, Teixeira, Leandro B C, Occelli, Laurence M, Storey, Eric S, Ying, Gui-Shuang, Komáromy, András M

“…Inherited primary open-angle glaucoma (POAG) in Beagle dogs is a well-established large animal model of glaucoma and is caused by a G661R missense mutation in…”
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CNGB3 Missense Variant Causes Recessive Achromatopsia in Original Braunvieh Cattle by Häfliger, Irene M, Marchionatti, Emma, Stengård, Michele, Wolf-Hofstetter, Sonja, Paris, Julia M, Jacinto, Joana G P, Watté, Christine, Voelter, Katrin, Occelli, Laurence M, Komáromy, András M, Oevermann, Anna, Goepfert, Christine, Borgo, Angelica, Roduit, Raphaël, Spengeler, Mirjam, Seefried, Franz R, Drögemüller, Cord

“…Sporadic occurrence of inherited eye disorders has been reported in cattle but so far pathogenic variants were found only for rare forms of cataract but not…”
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Validation of the eyeTelemed IOPvet indentation tonometer for use in dogs by Kapeller, Lydia E, Cabble, Ava G, Buckman, Phillip N, Harman, Christine D, Jacobson, Amanda L, Lawrence, Frank R, Komáromy, András M

“…To assess the accuracy of canine intraocular pressure (IOP) estimates from the eyeTelemed IOPvet indentation tonometer. Part 1 included 54 eyes from 28 Beagle…”
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Assessment of Rod, Cone, and Intrinsically Photosensitive Retinal Ganglion Cell Contributions to the Canine Chromatic Pupillary Response by Yeh, Connie Y, Koehl, Kristin L, Harman, Christine D, Iwabe, Simone, Guzman, José M, Petersen-Jones, Simon M, Kardon, Randy H, Komáromy, András M

“…The purpose of this study was to evaluate a chromatic pupillometry protocol for specific functional assessment of rods, cones, and intrinsically photosensitive…”
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Prophylactic anti‐glaucoma therapy in dogs with primary glaucoma: A practitioner survey of current medical protocols by Plummer, Caryn E., Bras, Dineli, Grozdanic, Sinisa, Komáromy, András M., McLellan, Gillian, Miller, Paul, Sapienza, John S., Teixeira, Leandro, Webb, Terah

“…Aim To examine the use of prophylactic anti‐glaucoma medications in the normotensive fellow eye in dogs with unilateral overt primary glaucoma by veterinary…”
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Outer retinal thickness and visibility of the choriocapillaris in four distinct retinal regions imaged with spectral domain optical coherence tomography in dogs and cats by Mischi, Elisa, Soukup, Petr, Harman, Christine D., Oikawa, Kazuya, Kowalska, Malwina E., Hartnack, Sonja, McLellan, Gillian J., Komáromy, András M., Pot, Simon A.

“…Purpose To evaluate the outer retinal band thickness and choriocapillaris (CC) visibility in four distinct retinal regions in dogs and cats imaged with…”
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Ocular pulse amplitude (OPA) in canine ADAMTS10 -open-angle glaucoma ( ADAMTS10 -OAG) by Raphtis, Vanessa A, Sharma, Dhruv, Wang, Sichao, Kim, Jae Y, Jacobson, Amanda L, Harman, Christine D, Komáromy, András M

“…The role of ocular rigidity and biomechanics remains incompletely understood in glaucoma, including assessing an individual's sensitivity to intraocular…”
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Primary angle-closure glaucoma with goniodysgenesis in a Beagle dog by Park, Shin Ae, Sledge, Dodd, Monahan, Colleen, Bartoe, Joshua T, Komáromy, András M

“…Open angle glaucoma is the only type of primary glaucoma reported in Beagles. This case report describes a primary angle-closure glaucoma in a Beagle and its…”
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Localized alopecia and suppression of hypothalamic-pituitary-adrenal (HPA) axis in dogs following treatment with difluprednate 0.05% ophthalmic emulsion (Durezol®) by Quantz, Katelin, Anderson, Amanda L, Harman, Christine D, Noland, Erica L, Del Valle, Jacquelyn M, Occelli, Laurence M, Burn, Jessica B, Petersen-Jones, Simon M, Langlois, Daniel K, Pirie, Chris G, Petersen, Annette D, Komáromy, András M

“…Despite the common use of topical ophthalmic corticosteroids in dogs, detailed reports on systemic and dermatologic adverse effects are limited. Nine…”
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A cyclic nucleotide-gated channel mutation associated with canine daylight blindness provides insight into a role for the S2 segment tri-Asp motif in channel biogenesis by Tanaka, Naoto, Delemotte, Lucie, Klein, Michael L, Komáromy, András M, Tanaka, Jacqueline C

“…Cone cyclic nucleotide-gated channels are tetramers formed by CNGA3 and CNGB3 subunits; CNGA3 subunits function as homotetrameric channels but CNGB3 exhibits…”
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Presumed neuroprotective therapies prescribed by veterinary ophthalmologists for canine degenerative retinal and optic nerve diseases by Hopper, Ryan G., Montiani‐Ferreira, Fabiano, Silva Pereira, Jorge, Fritz, Michele C., Ruggiero, Vickie J., Sapienza, John S., Kato, Kumiko, Komáromy, András M.

“…Objective To investigate veterinary ophthalmologists’ use of presumed neuroprotective therapies for degenerative retinal and optic nerve diseases in dogs…”
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