Search Results - "Kolyvanov, G. B."

Preclinical Pharmacokinetics of GZK-111, a Dipeptide with Neuroprotective Activity by Litvin, A. A., Kolyvanov, G. B., Bochkov, P. O., Shevchenko, R. V., Podol’ko, A. L., Kolyasnikova, K. N., Zherdev, V. P.

“…We studied the pharmacokinetics of GZK-111 (N-phenylacetyl-glycyl-L-proline ethyl ether), a compound with neuroprotective activity, and its metabolite CPG…”
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Metabolism of a New Dipeptide Neuroprotector in Rats by Kolyvanov, G. B., Bochkov, P. O., Litvin, A. A., Shevchenko, R. V., Podol’ko, A. L., Kravtsova, O. Yu, Kolyasnikova, K. N., Zherdev, V. P.

“…Metabolism of a new neuroprotector GZK-111 ( N -phenylacetylglycyl- L -proline ethyl ester) in rat blood plasma was studied by HPLC-mass spectrometry. Four…”
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Comparative Analysis of Tissue Availability for Afobazole and Compound M-11 by Viglinskaya, A. O, Bastrygin, D. V, Kolyvanov, G. B, Litvin, A. A, Zherdev, V. P, Mozhaeva, T. Ya

“…Comparative analysis of pharmacokinetic parameters of afobazole and its main metabolite M-11 after single intraperitoneal injections of their solutions (25…”
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Comparative Preclinical Pharmacokinetics and Bioavailability of Antidepressant GSB-106 Tablet Form by Kolyvanov, G. B., Zherdev, V. P., Gribakina, O. G., Bochkov, P. O., Shevchenko, R. V., Litvin, A. A., Blynskaya, E. V., Bueva, V. V.

“…Pharmacokinetics and relative bioavailability of antidepressant GSB-106 (hexamethylendiamide bis -( N -monosuccinyl- L -seryl- L -lysine) were determined in…”
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Elimination Half-Life of Short Peptide Drugs in Humans Extrapolated From Animal Pharmacokinetic Pharmacokinetic Studies by Litvin, A. A., Shevchenko, R. V., Kolyvanov, G. B., Bochkov, P. O., Smirnov, V. V., Raskin, S. Yu, Gribakina, O. G., Zherdev, V. P., Kolik, L. G., Gudasheva, T. A., Ivashkina, N. Yu

“…Results from an interspecies scaling study of the elimination half-lives of the anxiolytic GB-115 and the antipsychotic dilept in rats, rabbits, and humans are…”
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Excretion of afobazole and its metabolites with urine and feces in rats by Viglinskaya, A. O, Kolyvanov, G. B, Litvin, A. A, Zherdev, V. P, Seredenin, S. B

“…The amount of afobazole and identified metabolites was measured in the urine and feces of rats after intraperitoneal and peroral administration of the drug in…”
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Metabolism of a Novel Anxiolytic GML-1 in Rats by Novitskii, A. A., Bochkov, P. O., Shevchenko, R. V., Gribakina, O. G., Litvin, A. A., Kolyvanov, G. B., Zherdev, V. P.

“…Metabolism of a novel anxiolytic GML-1 ( N -benzyl- N -methyl-1-phenylpyrrolo[1,2-a]pirazin-3-carboxamide) in rat blood plasma was studied by HPLC-mass…”
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Comparative Pharmacokinetics and Relative Bioavailability of a New Anxiolytic GML-1 in Tablet Form by Novitskiy, A. A., Litvin, A. A., Shevchenko, R. V., Bochkov, P. O., Gribakina, O. G., Kolyvanov, G. B., Zherdev, V. P., Alekseev, K. V., Blynskaya, E. V., Yudina, D. V., Smirnov, V. V.

“…An open, single, crossover, pharmacokinetic study of GML-1 (dose 50 mg/kg) in rabbits after its oral administration in tablets and alone as a substance is…”
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Quantification of Hexamethylenediamide Bis(N-Monosuccinyl-L-Seryl-L-Lysine) (GSB-106) in the Blood Plasma by HPLC–MS by Grybakina, O. G., Lopatina, N. B., Blynskaya, E. V., Bochkov, P. O., Shevchenko, R. V., Litvin, A. A., Kolyvanov, G. B., Zherdev, V. P., Kondakov, S. E.

“…The technique of the quantitative determination of GSB-106 in the blood plasma of rats is developed and validated. The analysis is performed by HPLC–MS. The…”
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Comparison of Pharmacokinetics and Relative Bioavailability of Tablets and Substance of New Dipeptide Neuroleptic Dilept by Shevchenko, R. V., Litvin, A. A., Kolyvanov, G. B., Zherdev, V. P., Smirnov, V. V.

“…We studied pharmacokinetics of dilept after single cross-administration of tablets and substance of dilept in a dose of 40 mg to rabbits. The following…”
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Pharmacokinetics of a potential antiepileptic drug GIZh-298 by G. B. Kolyvanov, A. A. Litvin, O. Yu. Kravtsova, O. G. Gribakina, V. P. Zherdev

“…GIZh-298 pharmacokinetics was studied in rats after different dosage regimens.The aim of this study was to study GIZh-298 pharmacokinetics after its multiple…”
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Experimental pharmacokinetics of a new antiparkinsonian drug ADK-1113 by O. Yu. Kravtsova, D. A. Dvoryaninov, G. B. Kolyvanov, A. A. Litvin, O. G. Gribakina, V. P. Zherdev

“…The pharmacokinetics of a new antiparkinsonian drug ADK-1113 after single intravenous and intragastric administrations in mice at doses of 10 and 20 mg/kg was…”
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Excretion of Himantane and Its Metabolites with the Urine and Feces in Rats by Litvin, E. A., Bastrygin, D. V., Kolyvanov, G. B., Alekseyev, K. V., Zherdev, V. P.

“…The levels of himantane and its metabolites in daily urine and feces of rats were measured after intraperitoneal and oral dose of 25 mg/kg. The injected dose…”
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Absolute Bioavailability of Himantane in Rabbits by Litvin, E. A., Bastrygin, D. V., Kolyvanov, G. B., Alekseev, K. V., Zherdev, V. P.

“…Pharmacokinetic parameters of himantane and its metabolites in the blood plasma of rabbits were compared after single administration of himantane solution in a…”
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In vivo evaluation of the metabolic ratio of CYP2C9 and CYP1A2 drug markers after administration of afobazole in comparison to standard inducers and inhibitors of cytochromes by Novitskaia, Ia G, Gribakina, O G, Kolyvanov, G B, Zherdev, V P, Smirnov, V V, Seredenin, S B

“…The effect of subchronic peroral administration in effective doses of afobazole (5 mg/kg), and cytochrome P450 inductors (rifampicin, 13.4 mg/kg; phenytoin,…”
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Excretion of Compound M-11 and Its Metabolites with Urine and Feces in Rats by Bastrygin, D. V., Viglinskaya, A. O., Kolyvanov, G. B., Litvin, A. A., Bochkov, P. O., Mozhaeva, T. Ya, Zherdev, V. P.

“…The excretion of compound M-11 and its metabolites with the urine and feces was studied in rats after intraperitoneal and oral administration in a dose of 25…”
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Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GK-2 in rats. Part 2. Kinetics of distribution in organs and tissues by G. B. Kolyvanov, A. A. Litvin, P. O. Bochkov, O. Yu. Kravtsova, O. G. Gribakina, P. Yu. Povarnina, V. P. Zherdev

“…Relevance. To introduce the GK-2 compound into clinical practice, it is necessary to conduct a preclinical study of its pharmacokinetics, in particular, the…”
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Pharmacokinetic evaluation of a new prolonged dosage form of afobazole in comparison to commercially available tablets by Bochkov, P O, Litvin, A A, Kolyvanov, G B, Zherdev, V P, Blynskaia, E V, Grushevskaia, L N, Illarionov, A A

“…Afobazole pharmacokinetics upon oral administration of tablets prepared according to various technologies was studied in rabbits. The main pharmacokinetic…”
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Quantification of a potential anticonvulsant drug GIZh-298 in rat plasma by liquid chromatography-mass spectrometry by P. O. Bochkov, O. Yu. Kravtsova, G. B. Kolyvanov, A. A. Litvin, S. S. Boyko, V. P. Zherdev

“…GIZh-298 is a new derivative of 4-phenylpyrrolidone with anticonvulsant and nootropic effects. A selective and sensitive HPLC-MS technique for the quantitative…”
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Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in rats. Part 1. Single and multiple intravascular and extravascular administration. Testing the hypothesis of linearity of pharmacokinetics by O. Yu. Kravtsova, O. G. Gribakina, G. B. Kolyvanov, A. A. Litvin, P. O. Bochkov, P. Yu. Povarnina, V. P. Zherdev

“…The pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in the rat blood plasma after different routes of administration was studied. The…”
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