Search Results - "Kolybo, D V"

Nobel laureate Ilya I. Metchnikoff (1845-1916). Life story and scientific heritage by Ezepchuk, Yu V, Kolybo, D V

“…A century of science after I. Metchnikoff’s death demonstrated the truth in many of his views and judgments in the field of immunology, pathology,…”
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EFFECT OF DIPHTHERIA TOXIN T-DOMAIN ON ENDOSOMAL pH by Labyntsev, A J, Korotkevych, N V, Kolybo, D V, Komisarenko, S V

“…A key step in the mode of cytotoxic action of diphtheria toxin (DT) is the transfer of its catalytic domain (Cd) from endosomes into the cytosol. The main…”
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Effect of the T-domain on intracellular transport of diphtheria toxin by Labyntsev, A J, Kolybo, D V, Yurchenko, E S, Kaberniuk, A A, Korotkevych, N V, Komisarenko, S V

“…Subunit B of diphtheria toxin (DT), which consists of two domains: R (receptor-binding) and T (transmembrane), plays an important role in toxin-receptor…”
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IMMUNOBIOLOGY OF DIPHTHERIA. RECENT APPROACHES FOR THE PREVENTION, DIAGNOSIS, AND TREATMENT OF DISEASE by Kolybo, D V, Labyntsev, A A, Romaniuk, S I, Kaberniuk, A A, Oliinyk, O M, Korotkevich, N V, Komisarenko, S V

“…Diphtheria is a highly contagious life-threatening disease caused by the toxigenic strains of Corynebacterium diphtheria, which are transformed by a…”
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Role of the heparin-binding domain in intracellular trafficking of sHB-EGF by Krynina, O. I., Manoilov, K. Yu, Kolybo, D. V., Komisarenko, S. V.

“…Heparin-binding EGF-like growth factor (HB-EGF) is a member of the epidermal growth factor fami­ly that was proven as a potent mitogen and chemoattractant…”
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Production of recombinant SARS-COV-2 proteins and diphtheria toxoid CRM197-based fusion by Krynina, O. I., Romaniuk, S. I., Gorbatiuk, O. B., Korchynskyi, O. H., Rebriiev, А. V.

“…The quickly emerged global COVID-19 pandemic raised a desperate need in the development of protecting vaccines targeting this disease. Therefore, a generation…”
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Influence of human HB-EGF secreted form on cells with different EGFR and ErbB4 quantity by Krynina, O. I., Korotkevych, N. V., Labyntsev, A. J., Romaniuk, S. I., Kolybo, D. V., Komisarenko, S. V.

“…HB-EGF is one of the most potent ligands of EGFR and ErbB4 receptors. This growth factor plays a pivotal role in many cellular processes, but its effect…”
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Specificity and sensitivity of the new test for serological evaluation of tuberculosis using MPT83-MPT63 fusion antigen by Siromolot, A. A., Chudina, T. O., Danilova, I. S., Rekalova, O. M., Kolybo, D. V., Komisarenko, S. V.

“…The aim of this work was to characterize the experimental test-system based on MPT83-MPT63 fusion antigen with reference commercial diagnostics and investigate…”
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Particular Features of Diphtheria Toxin Internalization by Resistant and Sensitive Mammalian Cells by Manoilov, K. Y., Labyntsev, A. Ju, Korotkevych, N. V., Maksymovych, I. S., Kolybo, D. V., Komisarenko, S. V.

“…Several mammalian species are resistant to diphtheria toxin (DT). The DT receptor, proHB-EGF in resistant and sensitive species, has a different primary…”
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Enhancement of internalization of diphtheria toxin recombinant fragments in sensitive cells mediated by toxin’s T-domain by Manoilov, K. Yu, Labyntsev, A. J., Korotkevych, N. V., Kolybo, D. V.

“…Subunit B of diphtheria toxin (DT) and its R-domain differ by the presence of T-domain. The aim of the present work was to analyze the interaction of these…”
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RECOGNITION OF Mycobacterium tuberculosis ANTIGENS MPT63 AND MPT83 WITH MURINE POLYCLONAL AND scFv ANTIBODIES by Siromolot, A. A.

“…The goal of this study was to characterize serum immunoglobulin G (IgG) antibody responses during experimental immunization of laboratory mice by purified…”
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Changes in proHB-EGF expression after functional activation of the immune system cells by Chudina, T. O., Labintsev, A. J., Romaniuk, S. I., Kolybo, D. V., Komisarenko, S. V.

“…The level of proHB-EGF expression on J774, Raji, KG-1 cells derived from different types of human and mouse immune system cells under the standard in vitro…”
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ADJUVANT PROPERTIES OF NANOPARTICLES IMMOBILIZED RECOMBINANT DIPHTHERIA TOXOID FRAGMENT by Chudina, T. O.

“…The aim of the research was to compare the characteristics of nanoparticles with different chemical structure and size (colloidal gold Gold 1 and Gold 2,…”
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Necessity of translocation domain for realisation of cytostatic effect of non-toxic derivatives of diphtheria toxin by Manoilov, K. Y.

“…The aim of the work was to evaluate in vitro the cytostatic effect of recombinant fragments of the non-toxic point mutant of diphtheria toxin -- CRM197, which…”
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Recombinant diphtheria toxin derivatives: Perspectives of application by Romaniuk, S. I., Kolybo, D. V., Komisarenko, S. V.

“…Diphtheria toxin (DT) is a unique bacterial protein which consists of three domains with various biological functions. Using genetic engineering for the…”
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CYTOSTATIC EFFECT OF DOXORUBICIN-HYDROCHLORIDE WITH CRM197, AN INHIBITOR OF HB-EGF, IN SQUAMOUSCELL CARCINOMA by Radevych, I I, Siromolot, A A, Kolybo, D V

“…Cancer is one of the greatest threats to public health, its lethality comparable only to that of cardiovascular diseases, with the approach to its prevention…”
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HEPARIN-BINDING EGF–LIKE GROWTH FACTOR AS A PROSPECTIVE MEDIATOR OF TISSUE REPAIR AND REGENERATION by Didan, A.V.

“…Aim. To obtain bioactive recombinant human HB-EGF and investigate its proliferation capacity. Methods. The pET32(a)-HB-EGF cloning plasmid was extracted from…”
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Heparin-binding EGF-like growth factor: mechanisms of biological activity and potential therapeutic applications by Dronko, L. M., Lutsenko, T. M., Korotkevych, N. V., Vovk, I. O., Zhukova, D. A., Romaniuk, S. I., Siromolot, A. A., Labyntsev, A. J., Kolybo, D. V.

“…The diphtheria toxin receptor on sensitive mammalian cells is known as the membrane anchored precursor of heparin-binding EGF-like growth factor (HB-EGF). When…”
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EPITOPES IDENTIFICATION OF BROADLY NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST Corynebacterium diphtheriae EXOTOXIN by Kulyk, Ya.S.

“…Background. Better and high-potency vaccines against diphtheria are urgently needed to provide broader protection against diverse strains and subtypes…”
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OBTAINING OF RECOMBINANT ANALOGUE OF HUMAN SHB-EGF BY TRANSPOSON-TRANSPOSASE GENETIC SYSTEM by Korotkevych, N V, Labyntsev, A Yu, Kolybo, D V, Komisarenko, S V

“…The goal of this work was to obtain the recombinant soluble form of heparin-binding EGF-like growth factor sHB-EGF in eukaryotic cells based on transposon…”
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