Search Results - "Kolthur‐Seetharam, Ullas"

Drosophila Sirtuin 6 mediates developmental diet‐dependent programming of adult physiology and survival by Shukla, Namrata, Kolthur‐Seetharam, Ullas

“…Organisms in the wild experience unpredictable and diverse food availability throughout their lifespan. Over‐/under‐nutrition during development and in…”
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Improving In Vivo Tumor Accumulation and Efficacy of Platinum Antitumor Agents by Electronic Tuning of the Kinetic Lability by M, Manikandan, Chhatar, Sushanta, Gadre, Shubhankar, Paul, Subhadeep, Vaidya, Shreyas P., Khatri, Subhash, Duari, Prakash, Kode, Jyoti, Ingle, Arvind, Kolthur‐Seetharam, Ullas, Patra, Malay

“…The impact of kinetic lability or reactivity on in vitro cytotoxicity, stability in plasma, in vivo tumor and tissue accumulation, and antitumor efficacy of…”
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A Rationally Designed Bimetallic Platinum (II)‐Ferrocene Antitumor Agent Induces Non‐Apoptotic Cell Death and Exerts in Vivo Efficacy by Gadre, Shubhankar, Manikandan, M., Duari, Prakash, Chhatar, Sushant, Sharma, Astha, Khatri, Subhash, Kode, Jyoti, Barkume, Madan, Kasinathan, Nirmal Kumar, Nagare, Manasi, Patkar, Meena, Ingle, Arvind, Kumar, Mukesh, Kolthur‐Seetharam, Ullas, Patra, Malay

“…Despite phenomenal clinical success, the efficacy of platinum anticancer drugs is often compromised due to inherent and acquired drug resistant phenotypes in…”
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SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart by Khan, Danish, Sarikhani, Mohsen, Dasgupta, Subhajit, Maniyadath, Babukrishna, Pandit, Anwit S., Mishra, Sneha, Ahamed, Faiz, Dubey, Abhinav, Fathma, Nowrin, Atreya, Hanudatta S., Kolthur‐Seetharam, Ullas, Sundaresan, Nagalingam R.

“…Sirtuins are a family of enzymes, which govern a number of cellular processes essential for maintaining physiological balance. SIRT6, a nuclear sirtuin, is…”
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Multiple Functional Protein–Protein Interaction Interfaces Allosterically Regulate ATP‐Binding in Cyclin‐Dependent Kinase‐1 by Vishwakarma, Krishna Kant, Kolthur, Ullas Seetharam, Venkatramani, Ravindra

“…ABSTRACT The ATP‐dependent phosphorylation activity of cyclin‐dependent kinase 1 (CDK1), an essential enzyme for cell cycle progression, is regulated by…”
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Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets by Ramachandran, Deepti, Roy, Upasana, Garg, Swati, Ghosh, Sanchari, Pathak, Sulabha, Kolthur-Seetharam, Ullas

“…MicroRNA mir-9 is speculated to be involved in insulin secretion because of its ability to regulate exocytosis. Sirt1 is an NAD-dependent protein deacetylase…”
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Dendritic Fibrous Nanosilica (DFNS) for RNA Extraction from Cells by Maity, Ayan, Sandra, U. S, Kolthur-Seetharam, Ullas, Polshettiwar, Vivek

“…Efficient RNA extraction is critical for all downstream molecular applications and techniques. Despite the availability of several commercial kits, there is an…”
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G9a and Sirtuin6 epigenetically modulate host cholesterol accumulation to facilitate mycobacterial survival by Prakhar, Praveen, Bhatt, Bharat, Lohia, Gaurav Kumar, Shah, Awantika, Mukherjee, Tanushree, Kolthur-Seetharam, Ullas, Sundaresan, Nagalingam R, Rajmani, Raju S, Balaji, Kithiganahalli Narayanaswamy

“…Cholesterol derived from the host milieu forms a critical factor for mycobacterial pathogenesis. However, the molecular circuitry co-opted by Mycobacterium…”
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LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11 by Muralidharan, Bhavana, Khatri, Zeba, Maheshwari, Upasana, Gupta, Ritika, Roy, Basabdatta, Pradhan, Saurabh J, Karmodiya, Krishanpal, Padmanabhan, Hari, Shetty, Ashwin S, Balaji, Chinthapalli, Kolthur-Seetharam, Ullas, Macklis, Jeffrey D, Galande, Sanjeev, Tole, Shubha

“…In the developing cerebral cortex, sequential transcriptional programs take neuroepithelial cells from proliferating progenitors to differentiated neurons with…”
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Metabolic choreography of gene expression: nutrient transactions with the epigenome by Maniyadath, Babukrishna, Sandra, U S, Kolthur-Seetharam, Ullas

“…Eukaryotic complexity and thus their ability to respond to diverse cues are largely driven by varying expression of gene products, qualitatively and…”
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Central metabolic sensing remotely controls nutrient-sensitive endocrine response in Drosophila via Sir2/Sirt1-upd2-IIS axis by Banerjee, Kushal K, Deshpande, Rujuta S, Koppula, Pranavi, Ayyub, Champakali, Kolthur-Seetharam, Ullas

“…Endocrine signaling is central in coupling organismal nutrient status with maintenance of systemic metabolic homeostasis. While local nutrient sensing within…”
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dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner by Banerjee, Kushal Kr, Ayyub, Champakali, Ali, Syed Zeeshan, Mandot, Vinesh, Prasad, Nagaraj G., Kolthur-Seetharam, Ullas

“…Sir2, an evolutionarily conserved NAD+-dependent deacetylase, has been implicated as a key factor in mediating organismal life span. However, recent…”
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Loss of Hepatic Oscillatory Fed microRNAs Abrogates Refed Transition and Causes Liver Dysfunctions by Maniyadath, Babukrishna, Chattopadhyay, Tandrika, Verma, Srikant, Kumari, Sujata, Kulkarni, Prineeta, Banerjee, Kushal, Lazarus, Asmitha, Kokane, Saurabh S., Shetty, Trupti, Anamika, Krishanpal, Kolthur-Seetharam, Ullas

“…Inability to mediate fed-fast transitions in the liver is known to cause metabolic dysfunctions and diseases. Intuitively, a failure to inhibit futile…”
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Fat Body dSir2 Regulates Muscle Mitochondrial Physiology and Energy Homeostasis Nonautonomously and Mimics the Autonomous Functions of dSir2 in Muscles by Banerjee, Kushal K., Ayyub, Champakali, Sengupta, Samudra, Kolthur-Seetharam, Ullas

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Control of AIF-mediated Cell Death by the Functional Interplay of SIRT1 and PARP-1 in Response to DNA Damage by Kolthur-Seetharam, Ullas, Dantzer, Françoise, McBurney, Michael W., Murcia1, Gilbert de, Sassone-Corsi, Paolo

“…Cell survival after genotoxic stress is determined by a counterbalance of pro- and anti-death factors. Sirtuins (SIRTs) are deacetylases that promote cell…”
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Identification of a Tissue-Restricted Isoform of SIRT1 Defines a Regulatory Domain that Encodes Specificity by Deota, Shaunak, Chattopadhyay, Tandrika, Ramachandran, Deepti, Armstrong, Eric, Camacho, Beatriz, Maniyadath, Babukrishna, Fulzele, Amit, Gonzalez-de-Peredo, Anne, Denu, John M., Kolthur-Seetharam, Ullas

“…The conserved NAD+-dependent deacylase SIRT1 plays pivotal, sometimes contrasting, roles in diverse physiological and pathophysiological conditions. In this…”
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Histone Deacetylase SIRT1 Controls Male Fertility in Mice Through Regulation of Hypothalamic-Pituitary Gonadotropin Signaling by Kolthur-Seetharam, Ullas, Teerds, Katja, Rooij, Dirk G. de, Wendling, Olivia, McBurney, Michael, Sassone-Corsi, Paolo, Davidson, Irwin

“…Sirtuins (SIRTs) are class-III NAD-dependent histone deacetylases (HDACs) that regulate various physiological processes. Inactivation of SIRT1 in the mouse…”
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Metabolic regulation of CTCF expression and chromatin association dictates starvation response in mice and flies by Sen, Devashish, Maniyadath, Babukrishna, Chowdhury, Shreyam, Kaur, Arshdeep, Khatri, Subhash, Chakraborty, Arnab, Mehendale, Neelay, Nadagouda, Snigdha, Sandra, U.S., Kamat, Siddhesh S., Kolthur-Seetharam, Ullas

“…Coordinated temporal control of gene expression is essential for physiological homeostasis, especially during metabolic transitions. However, the interplay…”
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Intervention by picroside II on FFAs induced lipid accumulation and lipotoxicity in HepG2 cells by Dhami-Shah, Hiteshi, Vaidya, Rama, Talwadekar, Manasi, Shaw, Eisha, Udipi, Shobha, Kolthur-Seetharam, Ullas, Vaidya, Ashok D.B.

“…Accumulation of free fatty acids (FFAs) in hepatocytes is a hallmark of liver dysfunction and non-alcoholic fatty liver disease (NAFLD). Excessive deposition…”
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SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK by Ho, Linh, Titus, Allen Sam, Banerjee, Kushal Kr, George, Suji, Lin, Wei, Deota, Shaunak, Saha, Asish K., Nakamura, Ken, Gut, Philipp, Verdin, Eric, Kolthur-Seetharam, Ullas

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