Sub-wavelength-resolution imaging of biological tissues using THz solid immersion microscopy

Sub-wavelength-resolution imaging of biological tissues using THz solid immersion microscopy

We have proposed a method of THz solid immersion microscopy, which yields imaging soft biological tissues with the sub-wavelength resolution up to 0.2-wavelengths. To achieve this advanced resolution, it employs a solid immersion phenomenon - i.e. a reduction in the dimensions of the THz beam causti...

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Bibliographic Details
Published in:2018 International Conference Laser Optics (ICLO) p. 519
Main Authors: Chernomyrdin, N.V., Tuchin, V.V., Zaytsev, K.I., Kucheryavenko, A.S., Kolontaeva, G.S., Schadko, A.O., Beshplav, S.-I.T., Malakhov, K.M., Komandin, G.A., Karasik, V.E., Spector, I.E.
Format: Conference Proceeding
Language:English
Published: IEEE 01-06-2018
Subjects:
Biological tissues
Detectors
Microscopy
solid immersion microscopy
Solids
Spatial resolution
sub-wavelength spatial resolution
terahertz imaging
terahertz microscopy
terahertz radiation
terahertz technology
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Summary:We have proposed a method of THz solid immersion microscopy, which yields imaging soft biological tissues with the sub-wavelength resolution up to 0.2-wavelengths. To achieve this advanced resolution, it employs a solid immersion phenomenon - i.e. a reduction in the dimensions of the THz beam caustic by its formation on a small distance behind the medium featuring high refractive index. We have assembled an experimental setup, which realizes the principles of the THz solid immersion microscopy, and proposed an approach for handling the soft tissue at the object plane. This setup uses a backwardwave oscillator, as a source of continuous-wave THz radiation, and a Golay cell, as a detector of the THz field intensity. We have examined the resolution of the THz solid immersion microscopy using both numerical simulations and experimental studies. Finally, in order to highlight the prospective of the proposed THz imaging modality, we have applied the experimental setup for imaging of representative examples of biological tissues.
ISBN:9781538636114
1538636115
DOI:10.1109/LO.2018.8435491