Methods for combination treatment of metastatic uveal melanoma

Uveal melanoma (UM) is a rare primary malignant tumor originating from uveal melanocytes (choroid (90%), ciliary body (6%), iris (4%)) of the eye. According to the aggregate data, the tumor incidence is 5.2 cases per 1 million population. In Russia this value varies between 6.23–8 cases per 1 millio...

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Bibliographic Details
Published in:	Bulletin of RSMU no. 2023(6)
Main Authors:	Kolomiets, KV, Ponomareva, ES, Posypina, YaR, Mihailov, II, Mandzhiev, CB, Povetkina, EV, Tuguz, RR, Bulgakov, SM, Repunova, VI
Format:	Journal Article
Language:	English
Published:	01-12-2023
Online Access:	Get full text
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Summary:	Uveal melanoma (UM) is a rare primary malignant tumor originating from uveal melanocytes (choroid (90%), ciliary body (6%), iris (4%)) of the eye. According to the aggregate data, the tumor incidence is 5.2 cases per 1 million population. In Russia this value varies between 6.23–8 cases per 1 million adult population across the regions. UM most often spreads to the liver (89–93%). The clinical case of using transarterial chemoembolization (carboplatin) in combination with immunotherapy (nivolumab + ipilimumab) in patients with metastatic liver disease from UM is provided. The disease control within 12 months has been achieved, which, in turn, demonstrates the possibility and efficacy of multidisciplinary approach.
ISSN:	2500-1094 2542-1204
DOI:	10.24075/brsmu.2023.051