Search Results - "Kolls, Jay. K."

Contributions of the intestinal microbiome in lung immunity by McAleer, Jeremy P., Kolls, Jay K.

“…The intestine is a critical site of immune cell development that not only controls intestinal immunity but extra‐intestinal immunity as well. Recent findings…”
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Directing traffic: IL-17 and IL-22 coordinate pulmonary immune defense by McAleer, Jeremy P., Kolls, Jay K.

“…Summary Respiratory infections and diseases are among the leading causes of death worldwide, and effective treatments probably require manipulating the…”
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SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery by Mulay, Apoorva, Konda, Bindu, Garcia, Gustavo, Yao, Changfu, Beil, Stephen, Villalba, Jaquelyn M., Koziol, Colin, Sen, Chandani, Purkayastha, Arunima, Kolls, Jay. K., Pociask, Derek A., Pessina, Patrizia, de Aja, Julio Sainz, Garcia-de-Alba, Carolina, Kim, Carla F., Gomperts, Brigitte, Arumugaswami, Vaithilingaraja, Stripp, Barry R.

“…Coronavirus disease 2019 (COVID-19) is the latest respiratory pandemic caused by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Although…”
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Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation by Atarashi, Koji, Suda, Wataru, Luo, Chengwei, Kawaguchi, Takaaki, Motoo, Iori, Narushima, Seiko, Kiguchi, Yuya, Yasuma, Keiko, Watanabe, Eiichiro, Tanoue, Takeshi, Thaiss, Christoph A., Sato, Mayuko, Toyooka, Kiminori, Said, Heba S., Yamagami, Hirokazu, Rice, Scott A., Gevers, Dirk, Johnson, Ryan C., Segre, Julia A., Chen, Kong, Kolls, Jay K., Elinav, Eran, Morita, Hidetoshi, Xavier, Ramnik J., Hattori, Masahira, Honda, Kenya

“…Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a…”
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Oncogenic Kras Activates a Hematopoietic-to-Epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia by McAllister, Florencia, Bailey, Jennifer M., Alsina, Janivette, Nirschl, Christopher J., Sharma, Rajni, Fan, Hongni, Rattigan, Yanique, Roeser, Jeffrey C., Lankapalli, Rachana H., Zhang, Hao, Jaffee, Elizabeth M., Drake, Charles G., Housseau, Franck, Maitra, Anirban, Kolls, Jay K., Sears, Cynthia L., Pardoll, Drew M., Leach, Steven D.

“…Many human cancers are dramatically accelerated by chronic inflammation. However, the specific cellular and molecular elements mediating this effect remain…”
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Regulation of Dendritic Cell Function by Vitamin D by Barragan, Myriam, Good, Misty, Kolls, Jay K

“…Studies over the last two decades have revealed profound immunomodulatory aspects of vitamin D on various aspects of the immune system. This review will…”
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The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice by Deshmukh, Hitesh S, Liu, Yuhong, Menkiti, Ogechukwu R, Mei, Junjie, Dai, Ning, O'Leary, Claire E, Oliver, Paula M, Kolls, Jay K, Weiser, Jeffrey N, Worthen, G Scott

“…Here, Hitesh S. Deshmukh et al. report that in neonates, establishment of the intestinal microbiota is associated with neutrophil development…”
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Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation by Kumar, Pawan, Monin, Leticia, Castillo, Patricia, Elsegeiny, Waleed, Horne, William, Eddens, Taylor, Vikram, Amit, Good, Misty, Schoenborn, Alexi A., Bibby, Kyle, Montelaro, Ronald C., Metzger, Dennis W., Gulati, Ajay S., Kolls, Jay K.

“…Interleukin-17 (IL-17) and IL-17 receptor (IL-17R) signaling are essential for regulating mucosal host defense against many invading pathogens. Commensal…”
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TH17 cells in asthma and COPD by Alcorn, John F, Crowe, Christopher R, Kolls, Jay K

“…Asthma and chronic obstructive pulmonary disease (COPD) represent two classes of chronic obstructive lung disorders that may share some similar immunologic…”
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The immunology of influenza virus-associated bacterial pneumonia by Robinson, Keven M, Kolls, Jay K, Alcorn, John F

“…Graphical abstract…”
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Interleukin‐22 treatment ameliorates alcoholic liver injury in a murine model of chronic‐binge ethanol feeding: Role of signal transducer and activator of transcription 3 by Ki, Sung Hwan, Park, Oygi, Zheng, Mingquan, Morales‐Ibanez, Oriol, Kolls, Jay K., Bataller, Ramon, Gao, Bin

“…Interleukin‐22 (IL‐22), a recently identified member of the IL‐10 family of cytokines that is produced by Th17 and natural killer cells, plays an important…”
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Microbiological Laboratory Testing in the Diagnosis of Fungal Infections in Pulmonary and Critical Care Practice. An Official American Thoracic Society Clinical Practice Guideline by Hage, Chadi A, Carmona, Eva M, Epelbaum, Oleg, Evans, Scott E, Gabe, Luke M, Haydour, Qusay, Knox, Kenneth S, Kolls, Jay K, Murad, M Hassan, Wengenack, Nancy L, Limper, Andrew H

“…Fungal infections are of increasing incidence and importance in immunocompromised and immunocompetent patients. Timely diagnosis relies on appropriate use of…”
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The role of Th17 cytokines in primary mucosal immunity by Kolls, Jay K, Khader, Shabaana A

“…Abstract The T helper type 17 (Th17) lineage of CD4+ T-cells produce several effector molecules including IL-17A, IL-17F, IL-21, and IL-22. In addition to…”
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Unexpected role for IL-17 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection by Gopal, Radha, Monin, Leticia, Slight, Samantha, Uche, Uzodinma, Blanchard, Emmeline, Fallert Junecko, Beth A, Ramos-Payan, Rosalio, Stallings, Christina L, Reinhart, Todd A, Kolls, Jay K, Kaushal, Deepak, Nagarajan, Uma, Rangel-Moreno, Javier, Khader, Shabaana A

“…Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), infects one third of the world's population. Among these infections, clinical…”
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The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin by Weaver, Casey T, Elson, Charles O, Fouser, Lynette A, Kolls, Jay K

“…The recent discovery of a new CD4+ T cell subset, Th17, has transformed our understanding of the pathogenetic basis of an increasing number of chronic…”
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Th17 Cells Mediate Clade-Specific, Serotype-Independent Mucosal Immunity by Chen, Kong, McAleer, Jeremy P., Lin, Yuan, Paterson, David L., Zheng, Mingquan, Alcorn, John F., Weaver, Casey T., Kolls, Jay K.

“…The interleukin-17 (IL-17) family of cytokines phylogenetically predates the evolution of T cells in jawed vertebrates, suggesting that the ontogeny of the…”
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Pharmacotherapy and adjunctive treatment for idiopathic pulmonary fibrosis (IPF) by Saito, Shigeki, Alkhatib, Ala, Kolls, Jay K, Kondoh, Yasuhiro, Lasky, Joseph A

“…Idiopathic pulmonary fibrosis (IPF) is an advancing and fatal lung disease with increasing incidence and prevalence. Nintedanib and pirfenidone were approved…”
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Proinflammatory T helper type 17 cells are effective B-cell helpers by Mitsdoerffer, Meike, Lee, Youjin, Jäger, Anneli, Kim, Hye-Jung, Korn, Thomas, Kolls, Jay K., Cantor, Harvey, Bettelli, Estelle, Kuchroo, Vijay K.

“…T helper type 17 (TH17) cells are highly proinflammatory effector T cells that are characterized by the production of high amounts of IL-17A, IL-17F, IL-21,…”
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Th17 cytokines and mucosal immunity by Dubin, Patricia J, Kolls, Jay K

“…The T-helper 17 (Th17) lineage is a recently described subset of memory T cells that is characterized by its CD4⁺ status and its ability to make a…”
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MCPIP1 Endoribonuclease Activity Negatively Regulates Interleukin-17-Mediated Signaling and Inflammation by Garg, Abhishek V., Amatya, Nilesh, Chen, Kong, Cruz, J. Agustin, Grover, Prerna, Whibley, Natasha, Conti, Heather R., Hernandez Mir, Gerard, Sirakova, Tatiana, Childs, Erin C., Smithgall, Thomas E., Biswas, Partha S., Kolls, Jay K., McGeachy, Mandy J., Kolattukudy, Pappachan E., Gaffen, Sarah L.

“…Interleukin-17 (IL-17) induces pathology in autoimmunity and infections; therefore, constraint of this pathway is an essential component of its regulation. We…”
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