Search Results - "Kolls, Jay"

Neutrophilic Inflammation in Asthma and Association with Disease Severity by Ray, Anuradha, Kolls, Jay K.

“…Asthma is a chronic inflammatory disorder of the airways. While the local infiltration of eosinophils and mast cells, and their role in the disease have long…”
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Diagnosing Pneumocystis jirovecii pneumonia: A review of current methods and novel approaches by Bateman, Marjorie, Oladele, Rita, Kolls, Jay K

“…Abstract Pneumocystis jirovecii can cause life-threatening pneumonia in immunocompromised patients. Traditional diagnostic testing has relied on staining and…”
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Interluekin-17A (IL17A) by Chen, Kong, Kolls, Jay K.

“…The discovery of the key roles of interleukin-17A (IL-17A) and IL-17A producing cells in inflammation, autoimmune diseases and host defense has led to the…”
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Regulation of Dendritic Cell Function by Vitamin D by Barragan, Myriam, Good, Misty, Kolls, Jay K

“…Studies over the last two decades have revealed profound immunomodulatory aspects of vitamin D on various aspects of the immune system. This review will…”
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Contributions of the intestinal microbiome in lung immunity by McAleer, Jeremy P., Kolls, Jay K.

“…The intestine is a critical site of immune cell development that not only controls intestinal immunity but extra‐intestinal immunity as well. Recent findings…”
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The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation by Ouyang, Wenjun, Kolls, Jay K., Zheng, Yan

“…T helper 17 (Th17) cells belong to a recently identified T helper subset, in addition to the traditional Th1 and Th2 subsets. These cells are characterized as…”
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Updates on T helper type 17 immunity in respiratory disease by Iwanaga, Naoki, Kolls, Jay K.

“…Summary Interleukin‐17 (IL‐17)‐producing cells play a critical role in mucosal immunity including the respiratory tract. This review will highlight recent…”
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SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery by Mulay, Apoorva, Konda, Bindu, Garcia, Gustavo, Yao, Changfu, Beil, Stephen, Villalba, Jaquelyn M., Koziol, Colin, Sen, Chandani, Purkayastha, Arunima, Kolls, Jay. K., Pociask, Derek A., Pessina, Patrizia, de Aja, Julio Sainz, Garcia-de-Alba, Carolina, Kim, Carla F., Gomperts, Brigitte, Arumugaswami, Vaithilingaraja, Stripp, Barry R.

“…Coronavirus disease 2019 (COVID-19) is the latest respiratory pandemic caused by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Although…”
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Directing traffic: IL-17 and IL-22 coordinate pulmonary immune defense by McAleer, Jeremy P., Kolls, Jay K.

“…Summary Respiratory infections and diseases are among the leading causes of death worldwide, and effective treatments probably require manipulating the…”
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Unexpected role for IL-17 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection by Gopal, Radha, Monin, Leticia, Slight, Samantha, Uche, Uzodinma, Blanchard, Emmeline, Fallert Junecko, Beth A, Ramos-Payan, Rosalio, Stallings, Christina L, Reinhart, Todd A, Kolls, Jay K, Kaushal, Deepak, Nagarajan, Uma, Rangel-Moreno, Javier, Khader, Shabaana A

“…Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), infects one third of the world's population. Among these infections, clinical…”
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Oncogenic Kras Activates a Hematopoietic-to-Epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia by McAllister, Florencia, Bailey, Jennifer M., Alsina, Janivette, Nirschl, Christopher J., Sharma, Rajni, Fan, Hongni, Rattigan, Yanique, Roeser, Jeffrey C., Lankapalli, Rachana H., Zhang, Hao, Jaffee, Elizabeth M., Drake, Charles G., Housseau, Franck, Maitra, Anirban, Kolls, Jay K., Sears, Cynthia L., Pardoll, Drew M., Leach, Steven D.

“…Many human cancers are dramatically accelerated by chronic inflammation. However, the specific cellular and molecular elements mediating this effect remain…”
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T Cell-Mediated Host Immune Defenses in the Lung by Chen, Kong, Kolls, Jay K

“…Evidence has increasingly shown that the lungs are a major site of immune regulation. A robust and highly regulated immune response in the lung protects the…”
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Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation by Atarashi, Koji, Suda, Wataru, Luo, Chengwei, Kawaguchi, Takaaki, Motoo, Iori, Narushima, Seiko, Kiguchi, Yuya, Yasuma, Keiko, Watanabe, Eiichiro, Tanoue, Takeshi, Thaiss, Christoph A., Sato, Mayuko, Toyooka, Kiminori, Said, Heba S., Yamagami, Hirokazu, Rice, Scott A., Gevers, Dirk, Johnson, Ryan C., Segre, Julia A., Chen, Kong, Kolls, Jay K., Elinav, Eran, Morita, Hidetoshi, Xavier, Ramnik J., Hattori, Masahira, Honda, Kenya

“…Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a…”
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Th17 cell based vaccines in mucosal immunity by Kumar, Pawan, Chen, Kong, Kolls, Jay K

“…Highlights • Th17 responses show protection against both bacterial and fungal pathogens. • Mucosal and systemic vaccines can elicit protective Th17 responses…”
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Early Antibiotics in Cystic Fibrosis: Lessons from the Cystic Fibrosis Pig Model by Lu, Shiping, Kolls, Jay K.

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Th17 Cells Mediate Clade-Specific, Serotype-Independent Mucosal Immunity by Chen, Kong, McAleer, Jeremy P., Lin, Yuan, Paterson, David L., Zheng, Mingquan, Alcorn, John F., Weaver, Casey T., Kolls, Jay K.

“…The interleukin-17 (IL-17) family of cytokines phylogenetically predates the evolution of T cells in jawed vertebrates, suggesting that the ontogeny of the…”
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The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice by Deshmukh, Hitesh S, Liu, Yuhong, Menkiti, Ogechukwu R, Mei, Junjie, Dai, Ning, O'Leary, Claire E, Oliver, Paula M, Kolls, Jay K, Weiser, Jeffrey N, Worthen, G Scott

“…Here, Hitesh S. Deshmukh et al. report that in neonates, establishment of the intestinal microbiota is associated with neutrophil development…”
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Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation by Kumar, Pawan, Monin, Leticia, Castillo, Patricia, Elsegeiny, Waleed, Horne, William, Eddens, Taylor, Vikram, Amit, Good, Misty, Schoenborn, Alexi A., Bibby, Kyle, Montelaro, Ronald C., Metzger, Dennis W., Gulati, Ajay S., Kolls, Jay K.

“…Interleukin-17 (IL-17) and IL-17 receptor (IL-17R) signaling are essential for regulating mucosal host defense against many invading pathogens. Commensal…”
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Host defenses against bacterial lower respiratory tract infection by Eddens, Taylor, Kolls, Jay K

“…Highlights ► Pattern recognition receptors respond to a wide variety of bacterial pathogens in the lung. ► IL-23 stimulates innate production of IL-17 and…”
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TH17 cells in asthma and COPD by Alcorn, John F, Crowe, Christopher R, Kolls, Jay K

“…Asthma and chronic obstructive pulmonary disease (COPD) represent two classes of chronic obstructive lung disorders that may share some similar immunologic…”
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