Search Results - "Kollipara, Rahul K"

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs by Borromeo, Mark D., Savage, Trisha K., Kollipara, Rahul K., He, Min, Augustyn, Alexander, Osborne, Jihan K., Girard, Luc, Minna, John D., Gazdar, Adi F., Cobb, Melanie H., Johnson, Jane E.

“…Small cell lung carcinoma (SCLC) is a high-grade pulmonary neuroendocrine tumor. The transcription factors ASCL1 and NEUROD1 play crucial roles in promoting…”
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Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation by Carreira-Rosario, Arnaldo, Bhargava, Varsha, Hillebrand, Jens, Kollipara, Rahul K., Ramaswami, Mani, Buszczak, Michael

“…RNA-binding Fox (Rbfox) proteins have well-established roles in regulating alternative splicing, but specific Rbfox isoforms lack nuclear localization signals…”
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Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence by Fletcher-Sananikone, Eliot, Kanji, Suman, Tomimatsu, Nozomi, Di Cristofaro, Luis Fernando Macedo, Kollipara, Rahul K, Saha, Debabrata, Floyd, John R, Sung, Patrick, Hromas, Robert, Burns, Terry C, Kittler, Ralf, Habib, Amyn A, Mukherjee, Bipasha, Burma, Sandeep

“…Glioblastomas (GBM) are routinely treated with ionizing radiation (IR) but inevitably recur and develop therapy resistance. During treatment, the tissue…”
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Lsd1 restricts the number of germline stem cells by regulating multiple targets in escort cells by Eliazer, Susan, Palacios, Victor, Wang, Zhaohui, Kollipara, Rahul K, Kittler, Ralf, Buszczak, Michael

“…Specialized microenvironments called niches regulate tissue homeostasis by controlling the balance between stem cell self-renewal and the differentiation of…”
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Inhibition of Cancer Cell Proliferation by PPARγ Is Mediated by a Metabolic Switch that Increases Reactive Oxygen Species Levels by Srivastava, Nishi, Kollipara, Rahul K., Singh, Dinesh K., Sudderth, Jessica, Hu, Zeping, Nguyen, Hien, Wang, Shan, Humphries, Caroline G., Carstens, Ryan, Huffman, Kenneth E., DeBerardinis, Ralph J., Kittler, Ralf

“…The nuclear receptor peroxisome-proliferation-activated receptor gamma (PPARγ), a transcriptional master regulator of glucose and lipid metabolism, inhibits…”
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Comprehensive functional characterization of cancer–testis antigens defines obligate participation in multiple hallmarks of cancer by Maxfield, Kimberly E., Taus, Patrick J., Corcoran, Kathleen, Wooten, Joshua, Macion, Jennifer, Zhou, Yunyun, Borromeo, Mark, Kollipara, Rahul K., Yan, Jingsheng, Xie, Yang, Xie, Xian-Jin, Whitehurst, Angelique W.

“…Tumours frequently activate genes whose expression is otherwise biased to the testis, collectively known as cancer–testis antigens (CTAs). The extent to which…”
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Intrinsic DNA binding properties demonstrated for lineage-specifying basic helix-loop-helix transcription factors by Casey, Bradford H, Kollipara, Rahul K, Pozo, Karine, Johnson, Jane E

“…During development, transcription factors select distinct gene programs, providing the necessary regulatory complexity for temporal and tissue-specific gene…”
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Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin by Kim, Hyeonwoo, Rodriguez-Navas, Carlos, Kollipara, Rahul K., Kapur, Payal, Pedrosa, Ivan, Brugarolas, James, Kittler, Ralf, Ye, Jin

“…Some cancer cells exhibit elevated levels of free fatty acids (FAs) as well as high levels of β-catenin, a transcriptional co-activator that promotes their…”
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Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer by Wang, Shan, Kollipara, Rahul K., Srivastava, Nishi, Li, Rui, Ravindranathan, Preethi, Hernandez, Elizabeth, Freeman, Eva, Humphries, Caroline G., Kapur, Payal, Lotan, Yair, Fazli, Ladan, Gleave, Martin E., Plymate, Stephen R., Raj, Ganesh V., Hsieh, Jer-Tsong, Kittler, Ralf

“…The transcription factor E-twenty-six related gene (ERG), which is overexpressed through gene fusion with the androgen-responsive gene transmembrane protease,…”
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Global chromatin landscapes identify candidate noncoding modifiers of cardiac rhythm by Bhattacharyya, Samadrita, Kollipara, Rahul K, Orquera-Tornakian, Gabriela, Goetsch, Sean, Zhang, Minzhe, Perry, Cameron, Li, Boxun, Shelton, John M, Bhakta, Minoti, Duan, Jialei, Xie, Yang, Xiao, Guanghua, Evers, Bret M, Hon, Gary C, Kittler, Ralf, Munshi, Nikhil V

“…Comprehensive cis-regulatory landscapes are essential for accurate enhancer prediction and disease variant mapping. Although cis-regulatory element (CRE)…”
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HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing by Liu, Haoming, Liang, Chunyang, Kollipara, Rahul K., Matsui, Masayuki, Ke, Xiong, Jeong, Byung-Cheon, Wang, Zhiqiang, Yoo, Kyoung Shin, Yadav, Gaya P., Kinch, Lisa N., Grishin, Nicholas V., Nam, Yunsun, Corey, David R., Kittler, Ralf, Liu, Qinghua

“…Recent studies suggest that the microprocessor (Drosha-DGCR8) complex can be recruited to chromatin to catalyze co-transcriptional processing of primary…”
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An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis by Hight, Suzie K., Mootz, Allison, Kollipara, Rahul K., McMillan, Elizabeth, Yenerall, Paul, Otaki, Yoichi, Li, Long-Shan, Avila, Kimberley, Peyton, Michael, Rodriguez-Canales, Jaime, Mino, Barbara, Villalobos, Pamela, Girard, Luc, Dospoy, Patrick, Larsen, Jill, White, Michael A., Heymach, John V., Wistuba, Ignacio I., Kittler, Ralf, Minna, John D.

“…Using a mini-library of 1062 lentiviral shRNAs targeting 40 nuclear hormone receptors and 70 of their co-regulators, we searched for potential therapeutic…”
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Diagnostic and Prognostic Markers for Pancreatitis and Pancreatic Ductal Adenocarcinoma by Kantheti, Havish S, Hale, Michael A, Pal Choudhuri, Shreoshi, Huang, Huocong, Wang, Xu-Dong, Zolghadri, Yalda, Innamorati, Giulio, Manikonda, Sai Prasada Rao, Reddy, Naviya, Reddy, Sarthak, Kollipara, Rahul K, Lumani, Valbona, Girard, Luc, Bezrukov, Yakov, Demenkov, Pavel, MacDonald, Raymond J, Brekken, Rolf A, Yu, Yonghao, Wilkie, Thomas M

“…Diagnostic markers are desperately needed for the early detection of pancreatic ductal adenocarcinoma (PDA). We describe sets of markers expressed in temporal…”
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Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma by Singh, Dinesh K., Kollipara, Rahul K., Vemireddy, Vamsidara, Yang, Xiao-Li, Sun, Yuxiao, Regmi, Nanda, Klingler, Stefan, Hatanpaa, Kimmo J., Raisanen, Jack, Cho, Steve K., Sirasanagandla, Shyam, Nannepaga, Suraj, Piccirillo, Sara, Mashimo, Tomoyuki, Wang, Shan, Humphries, Caroline G., Mickey, Bruce, Maher, Elizabeth A., Zheng, Hongwu, Kim, Ryung S., Kittler, Ralf, Bachoo, Robert M.

“…Efforts to identify and target glioblastoma (GBM) drivers have primarily focused on receptor tyrosine kinases (RTKs). Clinical benefits, however, have been…”
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Repression by PRDM13 is critical for generating precision in neuronal identity by Mona, Bishakha, Uruena, Ana, Kollipara, Rahul K, Ma, Zhenzhong, Borromeo, Mark D, Chang, Joshua C, Johnson, Jane E

“…The mechanisms that activate some genes while silencing others are critical to ensure precision in lineage specification as multipotent progenitors become…”
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ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer by Pozo, Karine, Kollipara, Rahul K., Kelenis, Demetra P., Rodarte, Kathia E., Ullrich, Morgan S., Zhang, Xiaoyang, Minna, John D., Johnson, Jane E.

“…Lineage-defining transcription factors (LTFs) play key roles in small-cell lung cancer (SCLC) pathophysiology. Delineating the LTF-regulated genes operative in…”
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The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer by Wang, Shan, Kollipara, Rahul K, Humphries, Caroline G, Ma, Shi-Hong, Hutchinson, Ryan, Li, Rui, Siddiqui, Javed, Tomlins, Scott A, Raj, Ganesh V, Kittler, Ralf

“…Ets related gene (ERG) is a transcription factor that is overexpressed in 40% of prostate tumors due to a gene fusion between ERG and TMPRSS2. Because ERG…”
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Ablation of EWS-FLI1 by USP9X inhibition suppresses cancer cell growth in Ewing sarcoma by Wang, Shan, Huo, Xiaofang, Yang, Yiping, Mo, Yingxi, Kollipara, Rahul K., Kittler, Ralf

“…The neomorphic transcription factor EWS-FLI1 is a key driver of Ewing sarcoma. Ablation of EWS-FLI1 may present a promising therapeutic strategy for this…”
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An integrated functional genomic analysis identifies the antitumorigenic mechanism of action for PPARγ in lung cancer cells by Kollipara, Rahul K., Kittler, Ralf

“…Integrating the analysis of the cistrome of a transcription factor by ChIP-Seq with the study of its transcriptional output by microarray or RNA-Seq analysis…”
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A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics by Ocal, Ozhan, Pashkov, Victor, Kollipara, Rahul K, Zolghadri, Yalda, Cruz, Victoria H, Hale, Michael A, Heath, Blake R, Artyukhin, Alex B, Christie, Alana L, Tsoulfas, Pantelis, Lorens, James B, Swift, Galvin H, Brekken, Rolf A, Wilkie, Thomas M

“…Pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related deaths in the United States, and is projected to be second by 2025. It has…”
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