Search Results - "Koller, H."

Expert’s comment concerning Grand Rounds case entitled “Management of a pseudarthrosis with sagittal malalignment in a patient with ochronotic spondyloarthropathy” by Alkasem W, Boissiere L, Obeid I, Bourghli A (Eur Spine J; 2019: doi.org/10.1007/s00586-019-06020-2) by Koller, H.

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Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation by Kaushal, V, Dye, R, Pakavathkumar, P, Foveau, B, Flores, J, Hyman, B, Ghetti, B, Koller, B H, LeBlanc, A C

“…Neuronal active Caspase-6 (Casp6) is associated with Alzheimer disease (AD), cognitive impairment, and axonal degeneration. Caspase-1 (Casp1) can activate…”
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Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65 by Huang, Xi-Ping, Karpiak, Joel, Kroeze, Wesley K., Zhu, Hu, Chen, Xin, Moy, Sheryl S., Saddoris, Kara A., Nikolova, Viktoriya D., Farrell, Martilias S., Wang, Sheng, Mangano, Thomas J., Deshpande, Deepak A., Jiang, Alice, Penn, Raymond B., Jin, Jian, Koller, Beverly H., Kenakin, Terry, Shoichet, Brian K., Roth, Bryan L.

“…At least 120 non-olfactory G-protein-coupled receptors in the human genome are ‘orphans’ for which endogenous ligands are unknown, and many have no selective…”
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Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice by Conde, Eva, Bertrand, Romain, Balbino, Bianca, Bonnefoy, Jonathan, Stackowicz, Julien, Caillot, Noémie, Colaone, Fabien, Hamdi, Samir, Houmadi, Raïssa, Loste, Alexia, Kamphuis, Jasper B. J., Huetz, François, Guilleminault, Laurent, Gaudenzio, Nicolas, Mougel, Aurélie, Hardy, David, Snouwaert, John N., Koller, Beverly H., Serra, Vincent, Bruhns, Pierre, Grouard-Vogel, Géraldine, Reber, Laurent L.

“…Allergic asthma is characterized by elevated levels of IgE antibodies, type 2 cytokines such as interleukin-4 (IL-4) and IL-13, airway hyperresponsiveness…”
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Human ACE2 expression, a major tropism determinant for SARS-CoV-2, is regulated by upstream and intragenic elements by Snouwaert, John N, Jania, Leigh A, Nguyen, Trang, Martinez, David R, Schäfer, Alexandra, Catanzaro, Nicholas J, Gully, Kendra L, Baric, Ralph S, Heise, Mark, Ferris, Martin T, Anderson, Elizabeth, Pressey, Katia, Dillard, Jacob A, Taft-Benz, Sharon, Baxter, Victoria K, Ting, Jenny P-Y, Koller, Beverly H

“…Angiotensin-converting enzyme 2 (ACE2), part of the renin-angiotensin system (RAS), serves as an entry point for SARS-CoV-2, leading to viral proliferation in…”
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NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice by Kovarova, Martina, Hesker, Pamela R, Jania, Leigh, Nguyen, MyTrang, Snouwaert, John N, Xiang, Zhidan, Lommatzsch, Stephen E, Huang, Max T, Ting, Jenny P-Y, Koller, Beverly H

“…Acute inflammation in response to both exogenous and endogenous danger signals can lead to the assembly of cytoplasmic inflammasomes that stimulate the…”
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Accurate prediction of spontaneous lumbar curve correction following posterior selective thoracic fusion in adolescent idiopathic scoliosis using logistic regression models and clinical rationale by Koller, H., Hitzl, W., Marks, M. C., Newton, P. O.

“…Introduction Accurate prediction of spontaneous lumbar curve correction (SLCC) after selective thoracic fusion (STF) remains difficult. This study sought to…”
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Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid by Lin, Lan, Hwang, Bin-Jin, Culton, Donna A., Li, Ning, Burette, Susan, Koller, Beverly H., Messingham, Kelly A., Fairley, Janet A., Lee, James J., Hall, Russell P., An, Lijia, Diaz, Luis A., Liu, Zhi

“…Eosinophils are typically associated with unique inflammatory settings, including allergic inflammation and helminth infections. However, new information…”
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Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii by Gorfu, Gezahegn, Cirelli, Kimberly M, Melo, Mariane B, Mayer-Barber, Katrin, Crown, Devorah, Koller, Beverly H, Masters, Seth, Sher, Alan, Leppla, Stephen H, Moayeri, Mahtab, Saeij, Jeroen P J, Grigg, Michael E

“…Induction of immunity that limits Toxoplasma gondii infection in mice is critically dependent on the activation of the innate immune response. In this study,…”
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Fate of arsenicals in mice carrying the human AS3MT gene exposed to environmentally relevant levels of arsenite in drinking water by Douillet, Christelle, Miller, Madison, Cable, Peter H., Shi, Qing, El-Masri, Hisham, Matoušek, Tomáš, Koller, Beverly H., Thomas, David J., Stýblo, Miroslav

“…Although mice are widely used to study adverse effects of inorganic arsenic (iAs), higher rates of iAs methylation in mice than in humans may limit their…”
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Phenotypic alleviation in LAMB3‐mutated severe junctional epidermolysis bullosa by Medek, K., Klausegger, A., Ude‐Schoder, K., Prodinger, C., Breitenbach–Koller, H., Bauer, J.W., Laimer, M.

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Species-specific NLRP3 regulation and its role in CNS autoinflammatory diseases by Koller, Beverly H., Nguyen, MyTrang, Snouwaert, John N., Gabel, Christopher A., Ting, Jenny P.-Y.

“…The NLRP3 inflammasome is essential for caspase-1 activation and the release of interleukin (IL)-1β, IL-18, and gasdermin-D in myeloid cells. However, research…”
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Sociodemographic, sexual, and reproductive variables associated with pregnancy among adolescents from low socioeconomic background by Canavarro, Maria Cristina, Silva, Neuza, Diniz, Eva, Pereira, Marco, Koller, Sílvia H., Pires, Raquel

“…Adolescent pregnancy remains a public health concern in both developed and developing countries. Portugal and Brazil represent some of the best examples of…”
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Reversal of social deficits by subchronic oxytocin in two autism mouse models by Teng, Brian L., Nikolova, Viktoriya D., Riddick, Natallia V., Agster, Kara L., Crowley, James J., Baker, Lorinda K., Koller, Beverly H., Pedersen, Cort A., Jarstfer, Michael B., Moy, Sheryl S.

“…Social deficits are a hallmark feature of autism spectrum disorder (ASD) and related developmental syndromes. Although there is no standard treatment for…”
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Brca1 Controls Homology-Directed DNA Repair by Moynahan, Mary Ellen, Chiu, Joanne W, Koller, Beverly H, Jasin, Maria

“…Germline mutations in BRCA1 confer a high risk of breast and ovarian tumors. The role of BRCA1 in tumor suppression is not yet understood, but both…”
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AT1A Angiotensin Receptors in the Renal Proximal Tubule Regulate Blood Pressure by Gurley, Susan B., Riquier-Brison, Anne D.M., Schnermann, Jurgen, Sparks, Matthew A., Allen, Andrew M., Haase, Volker H., Snouwaert, John N., Le, Thu H., McDonough, Alicia A., Koller, Beverley H., Coffman, Thomas M.

“…Hypertension affects more than 1.5 billion people worldwide but the precise cause of elevated blood pressure (BP) cannot be determined in most affected…”
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PGE₂ promotes apoptosis induced by cytokine deprivation through EP3 receptor and induces Bim in mouse mast cells by Kovarova, Martina, Koller, Beverly H

“…Increased mast cell numbers are observed at sites of allergic inflammation and restoration of normal mast cell numbers is critical to the resolution of these…”
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Characteristics of deformity surgery in patients with severe and rigid cervical kyphosis (CK): results of the CSRS-Europe multi-centre study project by Koller, H., Ames, C., Mehdian, H., Bartels, R., Ferch, R., Deriven, V., Toyone, H., Shaffrey, C., Smith, J., Hitzl, W., Schröder, J., Robinson, Yohan

“…Introduction and purpose Little information exists on surgical characteristics, complications and outcomes with corrective surgery for rigid cervical kyphosis…”
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Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock by Hagar, Jon A, Edin, Matthew L, Lih, Fred B, Thurlow, Lance R, Koller, Beverly H, Cairns, Bruce A, Zeldin, Darryl C, Miao, Edward A

“…Critically ill patients typically present with hyperglycemia. Treatment with conventional insulin therapy (targeting 144-180 mg/dl) improves patient survival;…”
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Beyond detoxification: Pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile by Behrens, Kelsey A, Jania, Leigh A, Snouwaert, John N, Nguyen, MyTrang, Moy, Sheryl S, Tikunov, Andrey P, Macdonald, Jeffrey M, Koller, Beverly H

“…Environmental and endogenous electrophiles cause tissue damage through their high reactivity with endogenous nucleophiles such as DNA, proteins, and lipids…”
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