Search Results - "Koliwad, Suneil K."

Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function by Valdearcos, Martin, Robblee, Megan M., Benjamin, Daniel I., Nomura, Daniel K., Xu, Allison W., Koliwad, Suneil K.

“…Diets rich in saturated fat produce inflammation, gliosis, and neuronal stress in the mediobasal hypothalamus (MBH). Here, we show that microglia mediate this…”
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Hypothalamic Inflammation in the Control of Metabolic Function by Valdearcos, Martin, Xu, Allison W, Koliwad, Suneil K

“…Diet-induced obesity leads to devastating and common chronic diseases, fueling ongoing interest in determining new mechanisms underlying both obesity and its…”
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Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis by Chitraju, Chandramohan, Mejhert, Niklas, Haas, Joel T., Diaz-Ramirez, L. Grisell, Grueter, Carrie A., Imbriglio, Jason E., Pinto, Shirly, Koliwad, Suneil K., Walther, Tobias C., Farese, Robert V.

“…Triglyceride (TG) storage in adipose tissue provides the major reservoir for metabolic energy in mammals. During lipolysis, fatty acids (FAs) are hydrolyzed…”
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Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility by Valdearcos, Martin, Douglass, John D., Robblee, Megan M., Dorfman, Mauricio D., Stifler, Daniel R., Bennett, Mariko L., Gerritse, Irene, Fasnacht, Rachael, Barres, Ben A., Thaler, Joshua P., Koliwad, Suneil K.

“…Dietary excess triggers accumulation of pro-inflammatory microglia in the mediobasal hypothalamus (MBH), but the components of this microgliosis and its…”
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Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis by Hasegawa, Yutaka, Ikeda, Kenji, Chen, Yong, Alba, Diana L., Stifler, Daniel, Shinoda, Kosaku, Hosono, Takashi, Maretich, Pema, Yang, Yangyu, Ishigaki, Yasushi, Chi, Jingyi, Cohen, Paul, Koliwad, Suneil K., Kajimura, Shingo

“…Adipose tissue fibrosis is a hallmark of malfunction that is linked to insulin resistance and type 2 diabetes; however, what regulates this process remains…”
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Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells by Robblee, Megan M., Kim, Charles C., Abate, Jess Porter, Valdearcos, Martin, Sandlund, Karin L.M., Shenoy, Meera K., Volmer, Romain, Iwawaki, Takao, Koliwad, Suneil K.

“…Diets rich in saturated fatty acids (SFAs) produce a form of tissue inflammation driven by “metabolically activated” macrophages. We show that SFAs, when in…”
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Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice by Feng, Xiaomei, Valdearcos, Martin, Uchida, Yosuke, Lutrin, David, Maze, Mervyn, Koliwad, Suneil K

“…Surgery can induce cognitive decline, a risk that increases with advancing age. In rodents, postoperative cognitive decline (POCD) is associated with the…”
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Microglial Lipid Biology in the Hypothalamic Regulation of Metabolic Homeostasis by Folick, Andrew, Koliwad, Suneil K, Valdearcos, Martin

“…In mammals, myeloid cells help maintain the homeostasis of peripheral metabolic tissues, and their immunologic dysregulation contributes to the progression of…”
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Metabolic factors in the regulation of hypothalamic innate immune responses in obesity by Folick, Andrew, Cheang, Rachel T., Valdearcos, Martin, Koliwad, Suneil K.

“…The hypothalamus is a central regulator of body weight and energy homeostasis. There is increasing evidence that innate immune activation in the mediobasal…”
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The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health by Ang, Qi Yan, Alba, Diana L, Upadhyay, Vaibhav, Bisanz, Jordan E, Cai, Jingwei, Lee, Ho Lim, Barajas, Eliseo, Wei, Grace, Noecker, Cecilia, Patterson, Andrew D, Koliwad, Suneil K, Turnbaugh, Peter J

“…East Asians (EAs) experience worse metabolic health outcomes compared to other ethnic groups at lower body mass indices; however, the potential role of the gut…”
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Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility by Valdearcos, Martin, Douglass, John D., Robblee, Megan M., Dorfman, Mauricio D., Stifler, Daniel R., Bennett, Mariko L., Gerritse, Irene, Fasnacht, Rachael, Barres, Ben A., Thaler, Joshua P., Koliwad, Suneil K.

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Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier by Yulyaningsih, Ernie, Rudenko, Ivan A., Valdearcos, Martin, Dahlén, Emma, Vagena, Eirini, Chan, Alvin, Alvarez-Buylla, Arturo, Vaisse, Christian, Koliwad, Suneil K., Xu, Allison W.

“…Neurons expressing agouti-related protein (AgRP) are essential for feeding. The majority of these neurons are located outside the blood-brain barrier (BBB),…”
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Hypothalamic microglia as potential regulators of metabolic physiology by Valdearcos, Martin, Myers, Martin G., Koliwad, Suneil K.

“…Tissue-resident myeloid cells initiate local inflammation in response to infectious or injurious stimuli. Sixteen years ago, macrophages in the adipose tissue…”
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Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria by Bess, Elizabeth N., Bisanz, Jordan E., Yarza, Fauna, Bustion, Annamarie, Rich, Barry E., Li, Xingnan, Kitamura, Seiya, Waligurski, Emily, Ang, Qi Yan, Alba, Diana L., Spanogiannopoulos, Peter, Nayfach, Stephen, Koliwad, Suneil K., Wolan, Dennis W., Franke, Adrian A., Turnbaugh, Peter J.

“…Plant-derived lignans, consumed daily by most individuals, are thought to protect against cancer and other diseases 1 ; however, their bioactivity requires gut…”
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Regulation of Hepatic Lipid Accumulation and Distribution by Agouti-Related Protein in Male Mice by Maier, Matthew T, Vilhelmsson, Anna, Louie, Sharon M, Vagena, Eirini, Nomura, Daniel K, Koliwad, Suneil K, Xu, Allison W

“…Proper regulation of energy metabolism requires neurons in the central nervous system to respond dynamically to signals that reflect the body's energy reserve,…”
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Angiopoietin-like 4 (ANGPTL4, Fasting-induced Adipose Factor) Is a Direct Glucocorticoid Receptor Target and Participates in Glucocorticoid-regulated Triglyceride Metabolism by Koliwad, Suneil K., Kuo, Taiyi, Shipp, Lauren E., Gray, Nora E., Backhed, Fredrik, So, Alex Yick-Lun, Farese, Robert V., Wang, Jen-Chywan

“…Glucocorticoids are important regulators of lipid homeostasis, and chronically elevated glucocorticoid levels induce hypertriglyceridemia, hepatic steatosis,…”
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Lack of association between either outpatient or inpatient glycemic control and COVID-19 illness severity or mortality in patients with diabetes by Mehta, Paras B, Kohn, Michael A, Koliwad, Suneil K, Rushakoff, Robert J

“…IntroductionTo evaluate whether outpatient insulin treatment, hemoglobin A1c (HbA1c), glucose on admission, or glycemic control during hospitalization is…”
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A gene–diet interaction controlling relative intake of dietary carbohydrates and fats by Nelson, Nnamdi G., Wu, Lili, Maier, Matthew T., Lam, Diana, Cheang, Rachel, Alba, Diana, Huang, Alyssa, Neumann, Drexel A., Hill, Tess, Vagena, Eirini, Barsh, Gregory S., Medina, Marisa W., Krauss, Ronald M., Koliwad, Suneil K., Xu, Allison W.

“…Preference for dietary fat vs. carbohydrate varies markedly across free-living individuals. It is recognized that food choice is under genetic and…”
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Acyl-CoA:Diacylglycerol Acyltransferase 1 Expression Level in the Hematopoietic Compartment Impacts Inflammation in the Vascular Plaques of Atherosclerotic Mice by Vujic, Nemanja, Porter Abate, Jess, Schlager, Stefanie, David, Tovo, Kratky, Dagmar, Koliwad, Suneil K

“…The final step of triacylglycerol synthesis is catalyzed by acyl-CoA:diacylglycerol acyltransferases (DGATs). We have previously shown that ApoE-/-Dgat1-/-…”
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Leptin potentiates astrogenesis in the developing hypothalamus by Rottkamp, Daniele M, Rudenko, Ivan A, Maier, Matthew T, Roshanbin, Sahar, Yulyaningsih, Ernie, Perez, Luz, Valdearcos, Martin, Chua, Streamson, Koliwad, Suneil K, Xu, Allison W

“…Abstract Background The proper establishment of hypothalamic feeding circuits during early development has a profound influence on energy homeostasis, and…”
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