Search Results - "Kolis, Stanley P."

Process Safety in the Pharmaceutical IndustryPart I: Thermal and Reaction Hazard Evaluation Processes and Techniques by Allian, Ayman D, Shah, Nisha P, Ferretti, Antonio C, Brown, Derek B, Kolis, Stanley P, Sperry, Jeffrey B

“…Process safety groups in the pharmaceutical industry are important components of active pharmaceutical ingredient (API) development through its life cycle from…”
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Uncovering the Most Kinetically Influential Reaction Pathway Driving the Generation of HCN from Oxyma/DIC Adduct: A Theoretical Study by Gui, Lingfeng, Adjiman, Claire S., Galindo, Amparo, Sayyed, Fareed Bhasha, Kolis, Stanley P., Armstrong, Alan

“…The combination of ethyl (hydroxyimino)­cyanoacetate (Oxyma) and diisopropylcarbodiimide (DIC) has demonstrated superior performance in amino acid activation…”
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Quantum Mechanical Methods for Thermal Hazard Risk Assessment in Early Phase Pharmaceutical Development by Sayyed, Fareed Bhasha, Kolis, Stanley P, Xia, Han

“…Quantum mechanical (QM) applications to predict heat of reaction (ΔH r) and thermal stability of strained aminocarbocylic salts, diazo compounds, and…”
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Generation of Hydrogen Cyanide from the Reaction of Oxyma (Ethyl Cyano(hydroxyimino)acetate) and DIC (Diisopropylcarbodiimide) by McFarland, Adam D, Buser, Jonas Y, Embry, Matthew C, Held, Charles B, Kolis, Stanley P

“…Evolution of hydrogen cyanide (HCN) during amino acid activation using the reagent combination ethyl cyano­(hydroxyimino)­acetate…”
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Hydrogen Evolution from Telescoped Miyaura Borylation and Suzuki Couplings Utilizing Diboron Reagents: Process Safety and Hazard Considerations by Merritt, Jeremy M, Borkar, Indrakant, Buser, Jonas Y, Brewer, Alison Campbell, Campos, Odilon, Fleming, Jeffrey, Hansen, Caoimhe, Humenik, Ashley, Jeffery, Stephen, Kokitkar, Prashant B, Kolis, Stanley P, Forst, Mindy B, Lambertus, Gordon R, Martinelli, Joseph R, McCartan, Ciaran, Moursy, Hossam, Murphy, Donal, Murray, Michael M, O’Donnell, Kevin, O’Sullivan, Rita, Richardson, Gary A, Xia, Han

“…The hazard assessment of a telescoped Miyaura borylation and Suzuki coupling reaction employing bis­(pinacolato)­diboron (BisPin), used in the developmental…”
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Synthesis of Aryl- and Heteroaryl[a]pyrrolo[3,4-c]carbazoles by Sanchez-Martinez, Concha, Faul, Margaret M, Shih, Chuan, Sullivan, Kevin A, Grutsch, John L, Cooper, Jeremy T, Kolis, Stanley P

“…Synthesis of aryl- and hetero[a]pyrrolo[3,4-c]carbazoles by photochemical oxidation and Heck cyclization are described. Photochemical oxidation of 2-naphthyl…”
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Continuous Platform To Generate Nitroalkanes On-Demand (in Situ) Using Peracetic Acid-Mediated Oxidation in a PFA Pipes-in-Series Reactor by Tsukanov, Sergey V, Johnson, Martin D, May, Scott A, Kolis, Stanley P, Yates, Matthew H, Johnston, Jeffrey N

“…The synthetic utility of the aza-Henry reaction can be diminished on scale by potential hazards associated with the use of peracid to prepare nitroalkane…”
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Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid–Base Catalyst with Recycle by Tsukanov, Sergey V, Johnson, Martin D, May, Scott A, Rosemeyer, Morgan, Watkins, Michael A, Kolis, Stanley P, Yates, Matthew H, Johnston, Jeffrey N

“…A stereoselective aza-Henry reaction between an arylnitromethane and Boc-protected aryl aldimine using a homogeneous Brønsted acid–base catalyst was translated…”
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Synthesis of BACE Inhibitor LY2886721. Part II. Isoxazolidines as Precursors to Chiral Aminothiazines, Selective Peptide Coupling, and a Controlled Reactive Crystallization by Hansen, Marvin M, Jarmer, Daniel J, Arslantas, Enver, DeBaillie, Amy C, Frederick, Andrea L, Harding, Molly, Hoard, David W, Hollister, Adrienne, Huber, Dominique, Kolis, Stanley P, Kuehne-Willmore, Jennifer E, Kull, Thomas, Laurila, Michael E, Linder, Ryan J, Martin, Thomas J, Martinelli, Joseph R, McCulley, Michael J, Richey, Rachel N, Starkey, Derek R, Ward, Jeffrey A, Zaborenko, Nikolay, Zweifel, Theo

“…An efficient synthesis of LY2886721 (1) in five steps and 46% overall yield from the chiral nitrone cycloadduct 2 is presented. Minimizing formation of a…”
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Synthesis of BACE Inhibitor LY2886721. Part I. An Asymmetric Nitrone Cycloaddition Strategy by Kolis, Stanley P, Hansen, Marvin M, Arslantas, Enver, Brändli, Lukas, Buser, Jonas, DeBaillie, Amy C, Frederick, Andrea L, Hoard, David W, Hollister, Adrienne, Huber, Dominique, Kull, Thomas, Linder, Ryan J, Martin, Thomas J, Richey, Rachel N, Stutz, Alfred, Waibel, Michael, Ward, Jeffrey A, Zamfir, Alexandru

“…A scalable, asymmetric synthesis of (3aS,6aS)-6a-(5-bromo-2-fluorophenyl)-1-((R)-1-phenylpropyl)­tetrahydro-1H,3H-furo­[3,4-c]­isoxazole, a key intermediate in…”
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(S)-N-{3-[1-Cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: A Potent, Nonsteroidal, Functional Antagonist of the Mineralocorticoid Receptor by Bell, Michael G, Gernert, Douglas L, Grese, Timothy A, Belvo, Matthew D, Borromeo, Peter S, Kelley, Sally A, Kennedy, Joseph H, Kolis, Stanley P, Lander, Peter A, Richey, Rachel, Sharp, V. Scott, Stephenson, Gregory A, Williams, Jeffrey D, Yu, Hannah, Zimmerman, Karen M, Steinberg, Mitchell I, Jadhav, Prabhakar K

“…A novel, potent series of indole analogs were recently developed as MR antagonists, culminating in 14. This compound represents the first MR antagonist in this…”
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Development of a Practical Synthesis of an Aminoindanol-Derived M1 Agonist by Hansen, Marvin M, Borders, Sandra S. K, Clayton, Marcella T, Heath, Perry C, Kolis, Stanley P, Larsen, Samuel D, Linder, Ryan J, Reutzel-Edens, Susan M, Smith, Justin C, Tameze, Shella L, Ward, Jeffrey A, Weigel, Leland O

“…An efficient and scalable synthesis of the clinical candidate 1 is described. The first-generation synthesis built the enantioenriched nitro-aminoindanol core…”
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Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7- a]pyrrolo[3,4- c]carbazoles by Engler, Thomas A., Furness, Kelly, Malhotra, Sushant, Sanchez-Martinez, Concha, Shih, Chuan, Xie, Walter, Zhu, Guoxin, Zhou, Xun, Conner, Scott, Faul, Margaret M., Sullivan, Kevin A., Kolis, Stanley P., Brooks, Harold B., Patel, Bharvin, Schultz, Richard M., DeHahn, Tammy B., Kirmani, Kashif, Spencer, Charles D., Watkins, Scott A., Considine, Eileen L., Dempsey, Jack A., Ogg, Catherine A., Stamm, Nancy B., Anderson, Bryan D., Campbell, Robert M., Vasudevan, Vasu, Lytle, Michelle L.

“…The synthesis and CDK inhibitory properties of a series of indolo[6,7- a]pyrrolo[3,4- c]carbazoles is reported. In addition to their potent CDK activity, the…”
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Synthetic Approaches to Indolo[6,7-a]pyrrolo[3,4-c]carbazoles:  Potent Cyclin D1/CDK4 Inhibitors by Faul, Margaret M, Engler, Thomas A, Sullivan, Kevin A, Grutsch, John L, Clayton, Marcella T, Martinelli, Michael J, Pawlak, Joseph M, LeTourneau, Michael, Coffey, D. Scott, Pedersen, Steven W, Kolis, Stanley P, Furness, Kelly, Malhotra, Sushant, Al-awar, Rima S, Ray, James E

“…Synthesis of indolo[6,7-a]pyrrolo[3,4-c]carbazoles 1, a new class of cyclin D1/CDK4 inhibitors, by oxidation of the corresponding aryl indolylmaleimides 2,…”
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Zr-Catalyzed Olefin Alkylations and Allylic Substitution Reactions with Electrophiles by de Armas, Judith, Kolis, Stanley P, Hoveyda, Amir H

“…Disubstituted aryl olefins undergo efficient alkylations in the presence of 5 mol % Cp2ZrCl2, n-BuMgCl, and alkyl tosylates or alkyl bromides. In one class of…”
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Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors by Al-awar, Rima S, Ray, James E, Hecker, Kyle A, Joseph, Sajan, Huang, Jianping, Shih, Chuan, Brooks, Harold B, Spencer, Charles D, Watkins, Scott A, Schultz, Richard M, Considine, Eileen L, Faul, Margaret M, Sullivan, Kevin A, Kolis, Stanley P, Carr, Michael A, Zhang, Faming

“…The synthesis of a novel series of aza-1,7-annulated indoles is described along with their conversion to indolocarbazoles that proved to be potent kinase…”
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Synthesis of 7-cyano- and 7-acetamido-indoles via cyanocarbonation/hydrogenation of 7-formyl indole by Kolis, Stanley P., Clayton, Marcella T., Grutsch, John L., Faul, Margaret M.

“…A procedure for the synthesis of 7-cyano and 7-acetamido indoles via cyanocarbonation/hydrogenation of 7-formyl indole is presented. The process can be…”
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1,7-Annulated indolocarbazoles as cyclin-dependent kinase inhibitors by Al-awar, Rima S., Ray, James E., Hecker, Kyle A., Huang, Jianping, Waid, Philip P., Shih, Chuan, Brooks, Harold B., Spencer, Charles D., Watkins, Scott A., Patel, Bharvin R., Stamm, Nancy B., Ogg, Catherine A., Schultz, Richard M., Considine, Eileen L., Faul, Margaret M., Sullivan, Kevin A., Kolis, Stanley P., Grutsch, John L., Joseph, Sajan

“…A series of novel 1,7-annulated indolocarbazoles was prepared and evaluated for kinase inhibitory activity. The synthesis and kinase inhibitory activity of a…”
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Integrating model-based design of experiments and computer-aided solvent design by Gui, Lingfeng, Yu, Yijun, Oliyide, Titilola O., Siougkrou, Eirini, Armstrong, Alan, Galindo, Amparo, Sayyed, Fareed Bhasha, Kolis, Stanley P., Adjiman, Claire S.

“…Computer-aided molecular design (CAMD) methods can be used to generate promising solvents with enhanced reaction kinetics, given a reliable model of solvent…”
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Activation of Styrenes toward Diels−Alder Cycloadditions by Osmium(II):  Synthesis of Stereodefined Decalin Ring Systems by Kolis, Stanley P, Chordia, Mahendra D, Liu, Ronggang, Kopach, Michael E, Harman, W. Dean

“…The complex [Os(NH3)5(η2-anisole)]2+ reacts with acetals or Michael acceptors to form 4-methoxystyrene complexes that are exclusively coordinated at the arene…”
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