Search Results - "Koliesnik, Ievgen"

Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist by Glassman, Caleb R, Su, Leon, Majri-Morrison, Sonia S, Winkelmann, Hauke, Mo, Fei, Li, Peng, Pérez-Cruz, Magdiel, Ho, Peggy P, Koliesnik, Ievgen, Nagy, Nadine, Hnizdilova, Tereza, Picton, Lora K, Kovar, Marek, Bollyky, Paul, Steinman, Lawrence, Meyer, Everett, Piehler, Jacob, Leonard, Warren J, Garcia, K Christopher

“…Interleukin-2 is a pleiotropic cytokine that mediates both pro- and anti-inflammatory functions. Immune cells naturally differ in their sensitivity to IL-2 due…”
Get full text

Alternative NF-κB signaling controls peripheral homeostasis and function of regulatory T cells by Koliesnik, Ievgen O., Andreas, Nico, Thuy, Andreas, Sreekantapuram, Sravya, Haenold, Ronny, Weih, Falk

“…•P100-deficient Tregs have unrestricted alternative NF-κB signaling activation and demonstrate perturbed homeostasis and reduced competitiveness in…”
Get full text

The Heparan Sulfate Mimetic PG545 Modulates T Cell Responses and Prevents Delayed-Type Hypersensitivity by Koliesnik, Ievgen O, Kuipers, Hedwich F, Medina, Carlos O, Zihsler, Svenja, Liu, Dan, Van Belleghem, Jonas D, Bollyky, Paul L

“…The heparan sulfate mimetic PG545 (pixatimod) is under evaluation as an inhibitor of angiogenesis and metastasis including in human clinical trials. We have…”
Get full text

Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue by Martinez, Hunter A., Koliesnik, Ievgen, Kaber, Gernot, Reid, Jacqueline K., Nagy, Nadine, Barlow, Graham, Falk, Ben A., Medina, Carlos O., Hargil, Aviv, Zihsler, Svenja, Vlodavsky, Israel, Li, Jin-Ping, Pérez-Cruz, Magdiel, Tang, Sai-Wen, Meyer, Everett H., Wrenshall, Lucile E., Lord, James D., Garcia, K. Christopher, Palmer, Theo D., Steinman, Lawrence, Nepom, Gerald T., Wight, Thomas N., Bollyky, Paul L., Kuipers, Hedwich F.

“…Although FOXP3 + regulatory T cells (Treg) depend on IL-2 produced by other cells for their survival and function, the levels of IL-2 in inflamed tissue are…”
Get full text

Humanized Mouse Models for the Advancement of Innate Lymphoid Cell-Based Cancer Immunotherapies by Horowitz, Nina B, Mohammad, Imran, Moreno-Nieves, Uriel Y, Koliesnik, Ievgen, Tran, Quan, Sunwoo, John B

“…Innate lymphoid cells (ILCs) are a branch of the immune system that consists of diverse circulating and tissue-resident cells, which carry out functions…”
Get full text

RelB regulates Th17 differentiation in a cell-intrinsic manner by Koliesnik, Ievgen O., Andreas, Nico, Romanov, Vasily S., Sreekantapuram, Sravya, Krljanac, Branislav, Haenold, Ronny, Weih, Falk

“…The role of the alternative NF-κB pathway is mainly attributed to the lymphoid organ formation and blood cancer. However, its involvement in lymphocyte…”
Get full text

Natural Tr1-like cells do not confer long-term tolerogenic memory by Yadava, Koshika, Medina, Carlos Obed, Ishak, Heather, Gurevich, Irina, Kuipers, Hedwich, Shamskhou, Elya Ali, Koliesnik, Ievgen O, Moon, James J, Weaver, Casey, Nadeau, Kari Christine, Bollyky, Paul L

“…IL-10-producing Tr1 cells promote tolerance but their contributions to tolerogenic memory are unclear. Using 10BiT mice that carry a Foxp3-eGFP reporter and…”
Get full text

Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging by Tang, Duozhuang, Tao, Si, Chen, Zhiyang, Koliesnik, Ievgen Oleksandrovich, Calmes, Philip Gerald, Hoerr, Verena, Han, Bing, Gebert, Nadja, Zörnig, Martin, Löffler, Bettina, Morita, Yohei, Rudolph, Karl Lenhard

“…Dietary restriction (DR) improves health, delays tissue aging, and elongates survival in flies and worms. However, studies on laboratory mice and nonhuman…”
Get full text

Calix[4]arene methylenebisphosphonic acids as inhibitors of fibrin polymerization by Lugovskoy, Eduard V, Gritsenko, Pavel G, Koshel, Tatyana A, Koliesnik, Ievgen O, Cherenok, Serhey O, Kalchenko, Olga I, Kalchenko, Vitaliy I, Komisarenko, Serhey V

“…Calix[4]arenes bearing two or four methylenebisphosphonic acid groups at the macrocyclic upper rim have been studied with respect to their effects on fibrin…”
Get full text

Identification of undescribed Relb expression domains in the murine brain by new Relb:cre‐katushka reporter mice by Engelmann, Christian, Riemann, Marc, Carlstedt, Swen, Grimlowski, Randy, Andreas, Nico, Koliesnik, Ievgen, Meier, Elke, Austerfield, Phillip, Haenold, Ronny

“…Background Noncanonical NF‐κB signaling through activation of the transcription factor RelB acts as key regulator of cell lineage determination and…”
Get full text

The mononuclear phagocyte system obscures the accurate diagnosis of infected joint replacements by Manasherob, Robert, Warren, Shay I., Arora, Prerna, Heo, Lyong, Haddock, Naomi L., Koliesnik, Ievgen, Furukawa, Diasuke, Otieno-Ayayo, Z. Ngalo, Maloney, William J., Lowenberg, David W., Goodman, Stuart B., Amanatullah, Derek F.

“…Abstract Introduction Diagnosing infected joint replacements relies heavily on assessing the neutrophil response to bacteria. Bacteria form biofilms on joint…”
Get full text

Correction: Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging by Tang, Duozhuang, Tao, Si, Chen, Zhiyang, Koliesnik, Ievgen Oleksandrovich, Calmes, Philip Gerald, Hoerr, Verena, Han, Bing, Gebert, Nadja, Zörnig, Martin, Löffler, Bettina, Morita, Yohei, Rudolph, Karl Lenhard

Get full text

A new RelB‐dependent CD117+CD172a+ murine DC subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo by Andreas, Nico, Riemann, Marc, Castro, Carla N., Groth, Marco, Koliesnik, Ievgen, Engelmann, Christian, Sparwasser, Tim, Kamradt, Thomas, Haenold, Ronny, Weih, Falk

“…The NF‐κB transcription factor subunit RelB is important for the full activation of conventional dendritic cells (cDCs) during T‐cell‐dependent immune…”
Get full text

NF‐κB2/p100 deficiency impairs immune responses to T‐cell‐independent type 2 antigens by Krljanac, Branislav, Weih, Debra, Jacobsen, Ilse D., Hu, Desheng, Koliesnik, Ievgen, Reppe, Katrin, Witzenrath, Martin, Weih, Falk

“…Formation of the splenic marginal zone (MZ) depends on the alternative NF‐κB signaling pathway. Recently, we reported that unrestricted activation of this…”
Get full text

Abstract 1833: Novel IL-12 Partial Agonist For Cancer Immunotherapy Avoids NK-cell Mediated Toxicity by Koliesnik, Ievgen, Emmerich, Jan, Tran, Kim Q., Bauer, Michele, Totagrande, Michael, Jayaraman, Bhargavi, Buffone, Cindy, Balasubrahmanyam, Priyanka, Rokkam, Deepti, Malefyt, Rene de Waal, Zuniga, Luis, Greb, Heiko, Ratti, Navneet, Vivona, Sandro, Oft, Martin, Lupardus, Patrick J., Kastelein, Robert A.

“…Abstract Here we report on a novel human IL-12 partial agonist (hIL-12v) that has diminished binding to IL-12Rb1. IL-12v is designed to more selectively engage…”
Get full text

Abstract 1801: STK-012, an a/b-selective IL-2 activates tumor antigen specific CD25+ CD8 T cells to reject tumors without acute vascular toxicity by Oft, Martin, Ratti, Navneet, Vivona, Sandro, Emmerich, Jan, Riener, Romina, Koliesnik, Ievgen O., McCauley, Scott, Bauer, Michele, Semana, Marie, Rokkam, Deepti, Jayaraman, Bhargavi, Malefyt, Rene de Waal, Aspuria, Paul-Joseph, Totagrande, Michael, Mehta-Damani, Anita, Lupardus, Patrick J., Kastelein, Rob A.

“…Abstract High-dose Interleukin-2 (IL-2) monotherapy induces complete responses in cancer patients but its use is limited by acute vascular toxicities including…”
Get full text

NF-[kappa]B2/p100 deficiency impairs immune responses to T-cell-independent type 2 antigens by Krljanac, Branislav, Weih, Debra, Jacobsen, Ilse D, Hu, Desheng, Koliesnik, Ievgen, Reppe, Katrin, Witzenrath, Martin, Weih, Falk

“…Formation of the splenic marginal zone (MZ) depends on the alternative NF-[kappa]B signaling pathway. Recently, we reported that unrestricted activation of…”
Get full text