Search Results - "Kolev, N."

Mechanism-Guided Design and Discovery of Efficient Cytochrome P450-Derived C-H Amination Biocatalysts by Steck, Viktoria, Kolev, Joshua N, Ren, Xinkun, Fasan, Rudi

“…Cytochromes P450 have been recently identified as a promising class of biocatalysts for mediating C-H aminations via nitrene transfer, a valuable…”
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Merlin deficiency predicts FAK inhibitor sensitivity: a synthetic lethal relationship by Shapiro, Irina M, Kolev, Vihren N, Vidal, Christian M, Kadariya, Yuwaraj, Ring, Jennifer E, Wright, Quentin, Weaver, David T, Menges, Craig, Padval, Mahesh, McClatchey, Andrea I, Xu, Qunli, Testa, Joseph R, Pachter, Jonathan A

“…The goal of targeted therapy is to match a selective drug with a genetic lesion that predicts for drug sensitivity. In a diverse panel of cancer cell lines, we…”
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Enhancing the Efficiency and Regioselectivity of P450 Oxidation Catalysts by Unnatural Amino Acid Mutagenesis by Kolev, Joshua N., Zaengle, Jacqueline M., Ravikumar, Rajesh, Fasan, Rudi

“…The development of effective strategies for modulating the reactivity and selectivity of cytochrome P450 enzymes represents a key step toward expediting the…”
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Discovery of Potent Parthenolide-Based Antileukemic Agents Enabled by Late-Stage P450-Mediated CH Functionalization by Kolev, Joshua N, O’Dwyer, Kristen M, Jordan, Craig T, Fasan, Rudi

“…The sesquiterpene lactone parthenolide has recently attracted considerable attention owing to its promising antitumor properties, in particular in the context…”
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Assessment of students' satisfaction with virtual robotic surgery training by Kalinov, T., Georgiev, T., Bliznakova, K., Zlatarov, A., Kolev, N.

“…Nowadays, in Bulgaria there is a trend of increasing entry into the surgical field of robot-assisted surgery operations, which suggests a need for the…”
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Design of an in vitro biocatalytic cascade for the manufacture of islatravir by Huffman, Mark A, Fryszkowska, Anna, Alvizo, Oscar, Borra-Garske, Margie, Campos, Kevin R, Canada, Keith A, Devine, Paul N, Duan, Da, Forstater, Jacob H, Grosser, Shane T, Halsey, Holst M, Hughes, Gregory J, Jo, Junyong, Joyce, Leo A, Kolev, Joshua N, Liang, Jack, Maloney, Kevin M, Mann, Benjamin F, Marshall, Nicholas M, McLaughlin, Mark, Moore, Jeffrey C, Murphy, Grant S, Nawrat, Christopher C, Nazor, Jovana, Novick, Scott, Patel, Niki R, Rodriguez-Granillo, Agustina, Robaire, Sandra A, Sherer, Edward C, Truppo, Matthew D, Whittaker, Aaron M, Verma, Deeptak, Xiao, Li, Xu, Yingju, Yang, Hao

“…Enzyme-catalyzed reactions have begun to transform pharmaceutical manufacturing, offering levels of selectivity and tunability that can dramatically improve…”
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A rare case of isolated lung metastasis in the kidney by Stoykov, B., Genov, P., Kirilov, I., Yanev, K., Kolev, N., Dunev, V.

“…Renal metastases are very rare condition in the clinical practice. The treatment is individualized and it depends on general status of the patient, involving…”
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Lidar and spectroradiometer measurements of atmospheric aerosol optical characteristics over an urban area in Sofia, Bulgaria by Evgenieva, Ts. T., Kolev, N. I., Ts. Iliev, I., Savov, Pl. B., Kaprielov, B. K., Devara, P. C. S., Kolev, I. N.

“…A series of campaigns involving a systematic investigation of the atmosphere over an urban area of Sofia city were carried out. A European Aerosol Research…”
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A rare case of extramedullary hematopoiesis in adrenal mass by Kolev, N.H., Genov, P.P., Dunev, V.R., Stoykov, B.A.

“…Extramedullary hematopoiesis (EMH) is a compensatory mechanism for deficient formation or function of red blood cells. Very rarely, extramedullary…”
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Enzymatic C(sp3)‑H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones by Singh, Ritesh, Kolev, Joshua N, Sutera, Philip A, Fasan, Rudi

“…Cytochrome P450 enzymes can effectively promote the activation and cyclization of carbonazidate substrates to yield oxazolidinones via an intramolecular…”
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Premature ejaculation-operative management after failure of conservative treatment by Genov, P.P., Kolev, N.H., Dunev, V.R.

“…We report 1 case of microsurgical denervation of penis in men with lifelong premature ejaculation after failing to be treated conservatively. Although…”
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A rare case of Bellini duct carcinoma by Genov, P.P., Kolev, N.H., Dunev, V.R.

“…We present a rare clinical case of renal cell carcinoma from the collection tubules-carcinoma of Bellini. A 69 years old patient, enters in our department with…”
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Management and diagnosis of Nutcracker syndrome-a case report by Genov, P.P., Kirilov, I.V., Hristova, I.A., Kolev, N.H., Dunev, V.R., Stoykov, B.A.

“…Nutcracker syndrome (NCS), also known as left renal vein (LRV) entrapment syndrome is a condition that leads to stenosis of the aorto-mesenteric region of the…”
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APOLLO2 and TRIPOLI4 solutions of the OECD VVER-1000 LEU and MOX assembly benchmark by Petrov, N., Todorova, G., Kolev, N.P.

“…► APOLLO2 MOC calculation schemes were tested for VVER UGd and MOXGd assemblies. ► Depletion and branch calculations were performed. ► The results are close to…”
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Third Brazilian conference on statistical modelling in insurance and finance First announcement — Call for papers by Kolev, N.

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A rare clinical case of penile gangrene in a patient with chronic renal failure and diabetes mellitus by Dunev, V.R., Kolev, N.H., Genov, P.P.

“…We report here a case of penile gangrene due to penile calciphylaxis in a patient with diabetes mellitus and chronic renal failure. Initially the patient…”
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Three-point observation in the troposphere over Sofia-Plana Mountain, Bulgaria by Evgenieva, T, Wiman, B. L. B, Kolev, N. I, Savov, P. B, Donev, E. H, Ivanov, D. I, Danchovski, V, Kaprielov, B. K, Grigorieva, V. N, Iliev, I, Kolev, I. N

“…Based on a novel combination of approaches and instruments, this article presents campaign-based results from atmospheric boundary layer (ABL) height and…”
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Influence of the boundary layer development on the ozone concentration over an urban area by Kolev, N. I., Savov, P. B., Kaprielov, B. K., Grigorieva, V. N., Kolev, I. N.

“…Results obtained during two campaigns (summer 2004 and autumn 2005) of observation of the planetary boundary layer dynamics over the Sofia city urban area are…”
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Classical form of Kaposi sarcoma localized in penis by Dunev, V.R., Kolev, N.H., Genov, P.P., Sachdeva, M., Karaivanov, M.P.

“…We present you a case of 43 year old man with classical form of Kaposi sarcoma (KS) localized to the Penis who was HIV negative. Detailed pathological and…”
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Color dynamics of cooked sausages after nitrite reduction and incorporation of biologically active substances by Kolev, N. D., Vlahova-Vangelova, D. B., Balev, D. K., Dragoev, S. G.

“…   In most cases, the color of meat products is the factor influencing consumer choice. It’s formation and preservation is the highest priority. Sodium nitrite…”
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