Search Results - "Koletsky, Richard J"

Decreased transport of leptin across the blood–brain barrier in rats lacking the short form of the leptin receptor by Kastin, Abba J, Pan, Weihong, Maness, Lawrence M, Koletsky, Richard J, Ernsberger, Paul

“…Leptin is produced in adipose tissue in the periphery, but its satiety effect is exerted in the CNS that it reaches by a saturable transport system across the…”
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Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat by Takaya, K. (Kyoto University, Kyoto, Japan.), Ogawa, Y, Hiraoka, J, Hosoda, K, Yamori, Y, Nakao, K

“…The obese (ob) gene encodes a fat cell-derived blood-borne satiety factor (also known as leptin) that is involved in the regulation of energy homeostasis. Mice…”
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Reduced insulin receptor signaling in the obese spontaneously hypertensive Koletsky rat by Friedman, J.E, Ishizuka, T, Liu, S, Farrrell, C.J, Bedol, D, Koletsky, R.J, Kaung, H.L, Ernsberger, P

“…Insulin resistance is associated with both obesity and hypertension. However, the cellular mechanisms of insulin resistance in genetic models of…”
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Sitagliptin lowers glucagon and improves glucose tolerance in prediabetic obese SHROB rats by Chen, Brian, Moore, Alex, Escobedo, Liza V S, Koletsky, Matthew S, Hou, Diana, Koletsky, Richard J, Ernsberger, Paul

“…The SHROB (spontaneously hypertensive rat - obese strain) is a model of prediabetes and metabolic syndrome with insulin resistance, glucose intolerance and…”
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Metabolic actions of angiotensin receptor antagonists: PPAR-γ agonist actions or a class effect? by Ernsberger, Paul, Koletsky, Richard J

“…Accumulating basic and clinical data support the hypothesis that angiotensin receptor blockers have beneficial effects on glucose and lipid metabolism that are…”
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Therapeutic Actions of Allylmercaptocaptopril and Captopril in a Rat Model of Metabolic Syndrome by Ernsberger, Paul, Johnson, Janean L., Rosenthal, Talma, Mirelman, David, Koletsky, Richard J.

“…Hypertension often coexists with hyperlipidemia, insulin resistance, and glucose intolerance in metabolic syndrome. Allylmercaptocaptopril is a conjugate of…”
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Metabolic effects of antihypertensive agents: role of sympathoadrenal and renin-angiotensin systems by Ernsberger, Paul, Koletsky, Richard J

“…Reports of beneficial, neutral and adverse impacts of antihypertensive drug classes on glucose and lipid metabolism can be found in human data. Furthermore,…”
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Molecular Pathology in the Obese Spontaneous Hypertensive Koletsky Rat: A Model of Syndrome X by ERNSBERGER, PAUL, KOLETSKY, RICHARD J., FRIEDMAN, JACOB E.

“…The SHROB rat is a unique strain with genetic obesity, hypertriglyceridemia, hyperinsulinemia, renal disease with proteinuria, and genetically determined…”
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Biomedical Rationale for a Wellness Approach to Obesity: An Alternative to a focus on Weight Loss by Ernsberger, Paul, Koletsky, Richard J.

“…The direct medical hazards of obesity, although real, have been overstated. Because current remedies for obesity have little long‐term effectiveness, no…”
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Ventilation and metabolism among rat strains by Strohl, Kingman P, Thomas, Agnes J, St. Jean, Pamela, Schlenker, Evelyn H, Koletsky, Richard J, Schork, Nicholas J

“…Kingman P. Strohl 1 , Agnes J. Thomas 1 , Pamela St. Jean 1 , Evelyn H. Schlenker 2 , Richard J. Koletsky 1 , and Nicholas J. Schork 1 1  Departments of…”
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Plasma glucagon and free fatty acid responses to a glucose load in the obese spontaneous hypertensive rat (SHROB) model of metabolic syndrome X by Velliquette, Rodney A, Koletsky, Richard J, Ernsberger, Paul

“…Metabolic Syndrome X is a cluster of abnormalities including insulin resistance, hyperlipidemia, hypertension, and obesity. We sought to determine if excess…”
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Mechanisms of antihyperglycemic effects of moxonidine in the obese spontaneously hypertensive Koletsky rat (SHROB) by Ernsberger, P, Ishizuka, T, Liu, S, Farrell, C J, Bedol, D, Koletsky, R J, Friedman, J E

“…Increased activity of the sympathetic nervous system may be a critical factor in the development of impaired insulin secretion and insulin resistance. We…”
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Phenotypic consequences of a nonsense mutation in the leptin receptor gene (fak) in obese spontaneously hypertensive Koletsky rats (SHROB) by Ishizuka, T, Ernsberger, P, Liu, S, Bedol, D, Lehman, T M, Koletsky, R J, Friedman, J E

“…The genetically obese Koletsky rat (SHROB, fak) has a novel point mutation of the leptin receptor at amino acid +763, resulting in a premature stop codon in…”
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Refeeding Hypertension in Obese Spontaneously Hypertensive Rats by Ernsberger, Paul, Koletsky, Richard J, Baskin, Jon S, Foley, Mary

“…Very-low-calorie diets lower blood pressure acutely in obese humans and rats. However, refeeding after dietary restriction produces mild hypertension in rats…”
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Effects of weight cycling on urinary catecholamines: sympathoadrenal role in refeeding hypertension by Ernsberger, Paul, Koletsky, Richard J, Kilani, Ahmad, Viswan, Gita, Bedol, David

“…OBJECTIVESWe sought to determine whether the sympathetic nervous system plays a role in the hypertensive response to refeeding from a very low-calorie diet…”
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The I1-imidazoline receptor: from binding site to therapeutic target in cardiovascular disease by Ernsberger, Paul, Friedman, Jacob E, Koletsky, Richard J

“…OBJECTIVETo review previous work and present additional evidence characterizing the I1-imidazoline receptor and its role in cellular signaling, central…”
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Hydrochlorothiazide exacerbates metabolic syndrome in the SHROB rat model by Ernsberger, Paul, Agarwal, Akshita, Lute, Beth, Koletsky, Richard J

“…Abstract only Metabolic syndrome consists of hypertension, insulin resistance, dyslipidemia and fatty liver. Thiazides are the leading treatment for…”
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Weight Cycling and Mortality: Support From Animal Studies by Ernsberger, Paul, Koletsky, Richard J

“…To the Editor.—Lee and Paffenbarger1 demonstrate that weight loss increases cardiovascular mortality, even in overweight subjects. Weight fluctuation increased…”
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Augmentation ofobese(ob) Gene Expression and Leptin Secretion in Obese Spontaneously Hypertensive Rats (Obese SHR or Koletsky Rats) by Hiraoka, Junko, Hosoda, Kiminori, Ogawa, Yoshihiro, Ikeda, Katsumi, Nara, Yasuo, Masuzaki, Hiroaki, Takaya, Kazuhiko, Nakagawa, Kiyoshi, Mashimo, Tomoshi, Sawamura, Makoto, Koletsky, Richard J., Yamori, Yukio, Nakao, Kazuwa

“…To explore the pathophysiologic roles of theobese(ob) gene product, leptin, in the development of obesity and hypertension, we examinedobgene expression and…”
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Renal Angiotensin Receptor Mapping in Obese Spontaneously Hypertensive Rats by Ernsberger, Paul, Koletsky, Richard J, Collins, Laura A, Douglas, Janice G

“…Obese spontaneously hypertensive rats (SHR) develop nephropathy with severe proteinuria, but lean littermates do not develop renal disease. Intrarenal…”
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