Search Results - "Kolbe, Ludger"

How Much Sun Protection Is Needed?: Are We on the Way to Full-Spectrum Protection? by Kolbe, Ludger

“…The skin-damaging effects of the UV part of solar radiation are well known and therefore are a focus of photobiological research. However, UVR is only a small…”
Get full text

Inhibition of Human Tyrosinase Requires Molecular Motifs Distinctively Different from Mushroom Tyrosinase by Mann, Tobias, Gerwat, Wolfram, Batzer, Jan, Eggers, Kerstin, Scherner, Cathrin, Wenck, Horst, Stäb, Franz, Hearing, Vincent J., Röhm, Klaus-Heinrich, Kolbe, Ludger

“…Tyrosinase is the rate-limiting enzyme of melanin production and, accordingly, is the most prominent target for inhibiting hyperpigmentation. Numerous…”
Get full text

Structure-Activity Relationships of Thiazolyl Resorcinols, Potent and Selective Inhibitors of Human Tyrosinase by Mann, Tobias, Scherner, Cathrin, Röhm, Klaus-Heinrich, Kolbe, Ludger

“…Tyrosinase inhibitors are of great clinical interest as agents for the treatment of hyperpigmentary disorders; however, most compounds described in the…”
Get full text

Usefulness of alkaline hydrogen peroxide oxidation to analyze eumelanin and pheomelanin in various tissue samples: application to chemical analysis of human hair melanins by Ito, Shosuke, Nakanishi, Yukiko, Valenzuela, Robert K., Brilliant, Murray H., Kolbe, Ludger, Wakamatsu, Kazumasa

“…Summary Eumelanin and pheomelanin in tissue samples can be specifically measured as the markers pyrrole‐2,3,5‐tricarboxylic acid (PTCA) and…”
Get full text

UVA-induced oxidative degradation of melanins: fission of indole moiety in eumelanin and conversion to benzothiazole moiety in pheomelanin by Wakamatsu, Kazumasa, Nakanishi, Yukiko, Miyazaki, Narimi, Kolbe, Ludger, Ito, Shosuke

“…Summary Eumelanin is photoprotective while pheomelanin is phototoxic to pigmented tissues. Ultraviolet A (UVA)‐induced tanning seems to result from the…”
Get full text

Thiamidol® in moderate‐to‐severe melasma: 24‐week, randomized, double‐blind, vehicle‐controlled clinical study with subsequent regression phase by Roggenkamp, Dennis, Sammain, Adel, Fürstenau, Manuela, Kausch, Martina, Passeron, Thierry, Kolbe, Ludger

“…Thiamidol® was the most potent inhibitor of human tyrosinase out of 50 000 screened substances. In vivo, it was well tolerated and improved melasma…”
Get full text

Molecular and histological characterization of age spots by Choi, Wonseon, Yin, Lanlan, Smuda, Christoph, Batzer, Jan, Hearing, Vincent J., Kolbe, Ludger

“…Age spots, also called solar lentigines and lentigo senilis, are light brown to black pigmented lesions of various sizes that typically develop in chronically…”
Get full text

Human tyrosinase is able to oxidize both enantiomers of rhododendrol by Ito, Shosuke, Gerwat, Wolfram, Kolbe, Ludger, Yamashita, Toshiharu, Ojika, Makoto, Wakamatsu, Kazumasa

“…Summary Racemic RS‐4‐(4‐hydroxyphenyl)‐2‐butanol (rhododendrol, RD) was used as a topical skin‐whitening agent until it was recently reported to induce…”
Get full text

Regulation of Human Skin Pigmentation in situ by Repetitive UV Exposure: Molecular Characterization of Responses to UVA and/or UVB by Choi, Wonseon, Miyamura, Yoshinori, Wolber, Rainer, Smuda, Christoph, Reinhold, William, Liu, Hongfang, Kolbe, Ludger, Hearing, Vincent J.

“…UV radiation is a major environmental factor that affects pigmentation in human skin and can eventually result in various types of UV-induced skin cancers. The…”
Get full text

fibroblast-derived paracrine factor neuregulin-1 has a novel role in regulating the constitutive color and melanocyte function in human skin by Choi, Wonseon, Wolber, Rainer, Gerwat, Wolfram, Mann, Tobias, Batzer, Jan, Smuda, Christoph, Liu, Hongfang, Kolbe, Ludger, Hearing, Vincent J

“…Interactions between melanocytes and neighboring cells in the skin are important in regulating skin color in humans. We recently demonstrated that the less…”
Get full text

Concomitant DNA methylation and transcriptome signatures define epidermal responses to acute solar UV radiation by Holzscheck, Nicholas, Söhle, Jörn, Schläger, Torsten, Falckenhayn, Cassandra, Grönniger, Elke, Kolbe, Ludger, Wenck, Horst, Terstegen, Lara, Kaderali, Lars, Winnefeld, Marc, Gorges, Katharina

“…The simultaneous analysis of different regulatory levels of biological phenomena by means of multi-omics data integration has proven an invaluable tool in…”
Get full text

The deceptive nature of UVA tanning versus the modest protective effects of UVB tanning on human skin by Miyamura, Yoshinori, Coelho, Sergio G., Schlenz, Kathrin, Batzer, Jan, Smuda, Christoph, Choi, Wonseon, Brenner, Michaela, Passeron, Thierry, Zhang, Guofeng, Kolbe, Ludger, Wolber, Rainer, Hearing, Vincent J.

“…Summary The relationship between human skin pigmentation and protection from ultraviolet (UV) radiation is an important element underlying differences in skin…”
Get full text

Photoaging of human retinal pigment epithelium is accompanied by oxidative modifications of its eumelanin by Ito, Shosuke, Pilat, Anna, Gerwat, Wolfram, Skumatz, Christine M. B., Ito, Miho, Kiyono, Atsumi, Zadlo, Andrzej, Nakanishi, Yukiko, Kolbe, Ludger, Burke, Janice M., Sarna, Tadeusz, Wakamatsu, Kazumasa

“…Summary Although photodegradation of the retinal pigment epithelium (RPE) melanin may contribute to the etiology of age‐related macular degeneration, the…”
Get full text

Anti-inflammatory efficacy of licochalcone a : correlation of clinical potency and in vitro effects by KOLBE, Ludger, IMMEYER, Jeannine, WENCK, Horst, BATZER, Jan, WENSORRA, Ursula, TORN DIECK, Karen, MUNDT, Claudia, WOLBER, Rainer, STÄB, Franz, SCHÖNROCK, Uwe, CEILLEY, Roger I

“…Licochalcone A (LicA), a major phenolic constituent of the licorice species Glycyrrhiza inflata, has recently been reported to have anti-inflammatory as well…”
Get full text

UV radiation induces the release of angiopoietin-2 from dermal microvascular endothelial cells by Navid, Fatemeh, Kolbe, Ludger, Stäb, Franz, Korff, Thomas, Neufang, Gitta

“…:  In human skin, ultraviolet radiation (UVR)‐induced erythema is characterized by the inflammatory and angiogenic activation of dermal endothelial cells…”
Get full text

Short- and long-term effects of UV radiation on the pigmentation of human skin by Coelho, Sergio G, Choi, Wonseon, Brenner, Michaela, Miyamura, Yoshinori, Yamaguchi, Yuji, Wolber, Rainer, Smuda, Christoph, Batzer, Jan, Kolbe, Ludger, Ito, Shosuke, Wakamatsu, Kazumasa, Zmudzka, Barbara Z, Beer, Janusz Z, Miller, Sharon A, Hearing, Vincent J

“…The incidence of skin cancer, including cutaneous melanoma, has risen substantially in recent years, and epidemiological and laboratory studies show that UV…”
Get more information

Corticosteroid-induced atrophy and barrier impairment measured by non-invasive methods in human skin by Kolbe, L, Kligman, A M, Schreiner, V, Stoudemayer, T

“…Atrophy is a distressing side effect of potent corticosteroids. After open application of a high potency steroid, we monitored atrophogenicity by a variety of…”
Get more information

Natural Arctium lappa fruit extract improves the clinical signs of aging skin by Knott, Anja, Reuschlein, Katja, Mielke, Heiko, Wensorra, Ursula, Mummert, Christopher, Koop, Urte, Kausch, Martina, Kolbe, Ludger, Peters, Nils, Stäb, Franz, Wenck, Horst, Gallinat, Stefan

“…Summary Background  Subclinical, chronic tissue inflammation involving the generation of cytokines (e.g., interleukin‐6 and tumor necrosis factor‐alpha) might…”
Get full text

Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo by Germann, T, Bongartz, M, Dlugonska, H, Hess, H, Schmitt, E, Kolbe, L, Kölsch, E, Podlaski, F J, Gately, M K, Rüde, E

“…The influence of the cytokine interleukin-12 (IL-12) on humoral immune responses was studied in vivo. CBA/J mice immunized with protein antigens (keyhole…”
Get more information

Impact of visible light on skin health: The role of antioxidants and free radical quenchers in skin protection by Lim, Henry W., Kohli, Indermeet, Ruvolo, Eduardo, Kolbe, Ludger, Hamzavi, Iltefat H.

“…Until recently, the primary focus of photobiology has centered on the impact of UV radiation on skin health, including DNA damage and oncogenesis; however, the…”
Get full text