Search Results - "Kolb, Hartmuth C."

The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities by Walsh, Joseph C, Lebedev, Artem, Aten, Edward, Madsen, Kathleen, Marciano, Liane, Kolb, Hartmuth C

“…Tumor hypoxia is a well-established biological phenomenon that affects the curability of solid tumors, regardless of treatment modality. Especially for head…”
Get more information

Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future by Ariza, Manuela, Kolb, Hartmuth C, Moechars, Dieder, Rombouts, Frederik, Andrés, José Ignacio

“…Alzheimer’s disease (AD) is a chronic neurodegenerative disorder and the most common cause of dementia among the elderly population. The good correlation of…”
Get full text

[18 F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease by Xia, Chun-Fang, Arteaga, Janna, Chen, Gang, Gangadharmath, Umesh, Gomez, Luis F, Kasi, Dhanalakshmi, Lam, Chung, Liang, Qianwa, Liu, Changhui, Mocharla, Vani P, Mu, Fanrong, Sinha, Anjana, Su, Helen, Szardenings, A. Katrin, Walsh, Joseph C, Wang, Eric, Yu, Chul, Zhang, Wei, Zhao, Tieming, Kolb, Hartmuth C

“…Abstract Objective We wished to develop a highly selective positron emission tomography (PET) imaging agent targeting PHF-tau in human Alzheimer's disease (AD)…”
Get full text

The growing impact of click chemistry on drug discovery by Kolb, Hartmuth C, Sharpless, K.Barry

“…Click chemistry is a modular approach that uses only the most practical and reliable chemical transformations. Its applications are increasingly found in all…”
Get full text

Click Chemistry: Diverse Chemical Function from a Few Good Reactions by Kolb, Hartmuth C., Finn, M. G., Sharpless, K. Barry

“…Examination of nature's favorite molecules reveals a striking preference for making carbon–heteroatom bonds over carbon–carbon bonds—surely no surprise given…”
Get full text

Evaluation of [18F]-JNJ-64326067-AAA tau PET tracer in humans by Baker, Suzanne L, Provost, Karine, Thomas, Wesley, Whitman, AJ, Janabi, Mustafa, Schmidt, Mark E, Timmers, Maarten, Kolb, Hartmuth C, Rabinovici, Gil D, Jagust, William J

“…The [18F]-JNJ-64326067-AAA ([18F]-JNJ-067) tau tracer was evaluated in healthy older controls (HCs), mild cognitive impairment (MCI), Alzheimer’s disease (AD),…”
Get full text

Diagnostic and prognostic performance to detect Alzheimer's disease and clinical progression of a novel assay for plasma p-tau217 by Groot, Colin, Cicognola, Claudia, Bali, Divya, Triana-Baltzer, Gallen, Dage, Jeffrey L, Pontecorvo, Michael J, Kolb, Hartmuth C, Ossenkoppele, Rik, Janelidze, Shorena, Hansson, Oskar

“…Recent advances in disease-modifying treatments highlight the need for accurately identifying individuals in early Alzheimer's disease (AD) stages and for…”
Get full text

A highly selective and specific PET tracer for imaging of tau pathologies by Zhang, Wei, Arteaga, Janna, Cashion, Daniel K, Chen, Gang, Gangadharmath, Umesh, Gomez, Luis F, Kasi, Dhanalakshmi, Lam, Chung, Liang, Qianwa, Liu, Changhui, Mocharla, Vani P, Mu, Fanrong, Sinha, Anjana, Szardenings, A Katrin, Wang, Eric, Walsh, Joseph C, Xia, Chunfang, Yu, Chul, Zhao, Tieming, Kolb, Hartmuth C

“…Senile plaques and neurofibrillary tangles are prominent neuropathological hallmarks in Alzheimer's disease and are considered to be targets for therapeutic…”
Get more information

In Situ Selection of Lead Compounds by Click Chemistry:  Target-Guided Optimization of Acetylcholinesterase Inhibitors by Krasiński, Antoni, Radić, Zoran, Manetsch, Roman, Raushel, Jessica, Taylor, Palmer, Sharpless, K. Barry, Kolb, Hartmuth C.

“…The target-guided, in situ click chemistry approach to lead discovery has been successfully employed for discovering acetylcholinesterase (AChE) inhibitors by…”
Get full text

Inhibitors of HIV-1 Protease by Using In Situ Click Chemistry by Whiting, Matthew, Muldoon, John, Lin, Ying-Chuan, Silverman, Steven M., Lindstrom, William, Olson, Arthur J., Kolb, Hartmuth C., Finn, M. G., Sharpless, K. Barry, Elder, John H., Fokin, Valery V.

“…Twice poor equals potent: HIV‐1 Protease assembles its own potent inhibitor through formation of the triazole linkage from azide‐ and alkyne‐containing…”
Get full text

Development and validation of a high‐sensitivity assay for measuring p217+tau in plasma by Triana‐Baltzer, Gallen, Moughadam, Setareh, Slemmon, Randy, Van Kolen, Kristof, Theunis, Clara, Mercken, Marc, Kolb, Hartmuth C.

“…Introduction Diagnosis of Alzheimer's disease (AD) based on amyloid beta (A), pathologic tau (T), and neurodegeneration (N) biomarkers in peripheral fluids…”
Get full text

Preclinical evaluation and validation of [18F]HX4, a promising hypoxia marker for PET imaging by Dubois, Ludwig J, Lieuwes, Natasja G, Janssen, Marco H. M, Peeters, Wenny J. M, Windhorst, Albert D, Walsh, Joseph C, Kolb, Hartmuth C, Öllers, Michel C, Bussink, Johan, van Dongen, Guus A. M. S, van der Kogel, Albert, Lambin, Philippe

“…Hypoxia has been shown to be an important microenvironmental parameter influencing tumor progression and treatment efficacy. Patient guidance for…”
Get full text

Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics by Lee, Chung-Cheng, Sui, Guodong, Elizarov, Arkadij, Shu, Chengyi Jenny, Shin, Young-Shik, Dooley, Alek N, Huang, Jiang, Daridon, Antoine, Wyatt, Paul, Stout, David, Kolb, Hartmuth C, Witte, Owen N, Satyamurthy, Nagichettiar, Heath, James R, Phelps, Michael E, Quake, Stephen R, Tseng, Hsian-Rong

“…Microreactor technology has shown potential for optimizing synthetic efficiency, particularly in preparing sensitive compounds. We achieved the synthesis of an…”
Get full text

Freeze-Frame Inhibitor Captures Acetylcholinesterase in a Unique Conformation by Bourne, Yves, Kolb, Hartmuth C., Radić, Zoran, Sharpless, K. Barry, Taylor, Palmer, Marchot, Pascale

“…The 1,3-dipolar cycloaddition reaction between unactivated azides and acetylenes proceeds exceedingly slowly at room temperature. However, considerable rate…”
Get full text

Correction: Diagnostic and prognostic performance to detect Alzheimer's disease and clinical progression of a novel assay for plasma p-tau217 by Groot, Colin, Cicognola, Claudia, Bali, Divya, Triana-Baltzer, Gallen, Dage, Jeffrey L, Pontecorvo, Michael J, Kolb, Hartmuth C, Ossenkoppele, Rik, Janelidze, Shorena, Hansson, Oskar

Get full text

Integrated Microfluidics for Parallel Screening of an In Situ Click Chemistry Library by Wang, Jinyi, Sui, Guodong, Mocharla, Vani P., Lin, Rachel J., Phelps, Michael E., Kolb, Hartmuth C., Tseng, Hsian-Rong

“…State‐of‐the‐art: Automated chemical reaction circuits have been demonstrated to serve as a miniaturized operation platform for the parallel screening of 32 in…”
Get full text

Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis by Elizarov, Arkadij M, van Dam, R. Michael, Shin, Young Shik, Kolb, Hartmuth C, Padgett, Henry C, Stout, David, Shu, Jenny, Huang, Jiang, Daridon, Antoine, Heath, James R

“…An integrated elastomeric microfluidic device, with a footprint the size of a postage stamp, has been designed and optimized for multistep radiosynthesis of…”
Get full text

In Situ Click Chemistry: Enzyme-Generated Inhibitors of Carbonic Anhydrase II by Mocharla, Vani P., Colasson, Benoit, Lee, Lac V., Röper, Stefanie, Sharpless, K. Barry, Wong, Chi-Huey, Kolb, Hartmuth C.

“…Target‐guided synthesis: Rather than making and screening thousands of compounds for lead discovery, in situ click chemistry employs the biological target…”
Get full text

Personalized whole-brain neural mass models reveal combined Aβ and tau hyperexcitable influences in Alzheimer’s disease by Sanchez-Rodriguez, Lazaro M., Bezgin, Gleb, Carbonell, Felix, Therriault, Joseph, Fernandez-Arias, Jaime, Servaes, Stijn, Rahmouni, Nesrine, Tissot, Cécile, Stevenson, Jenna, Karikari, Thomas K., Ashton, Nicholas J., Benedet, Andréa L., Zetterberg, Henrik, Blennow, Kaj, Triana-Baltzer, Gallen, Kolb, Hartmuth C., Rosa-Neto, Pedro, Iturria-Medina, Yasser

“…Neuronal dysfunction and cognitive deterioration in Alzheimer’s disease (AD) are likely caused by multiple pathophysiological factors. However, mechanistic…”
Get full text

Applications of click chemistry in radiopharmaceutical development by Walsh, Joseph C, Kolb, Hartmuth C

“…Click chemistry, a concept that employs only practical and reliable transformations for compound synthesis, has made a significant impact in several areas of…”
Get full text