Search Results - "Kolaja, KL"

Opportunities for Use of Human iPS Cells in Predictive Toxicology by Anson, BD, Kolaja, KL, Kamp, TJ

“…Toxicity assessment is a major challenge in cost‐effective drug development, and there is a great need for better tools to accurately predict adverse drug…”
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Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action by Ganter, Brigitte, Tugendreich, Stuart, Pearson, Cecelia I., Ayanoglu, Eser, Baumhueter, Susanne, Bostian, Keith A., Brady, Lindsay, Browne, Leslie J., Calvin, John T., Day, Gwo-Jen, Breckenridge, Naiomi, Dunlea, Shane, Eynon, Barrett P., Furness, L. Mike, Ferng, Joe, Fielden, Mark R., Fujimoto, Susan Y., Gong, Li, Hu, Christopher, Idury, Radha, Judo, Michael S.B., Kolaja, Kyle L., Lee, May D., McSorley, Christopher, Minor, James M., Nair, Ramesh V., Natsoulis, Georges, Nguyen, Peter, Nicholson, Simone M., Pham, Hang, Roter, Alan H., Sun, Dongxu, Tan, Siqi, Thode, Silke, Tolley, Alexander M., Vladimirova, Antoaneta, Yang, Jian, Zhou, Zhiming, Jarnagin, Kurt

“…Successful drug discovery requires accurate decision making in order to advance the best candidates from initial lead identification to final approval…”
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The Role of Oxidative Stress in Chemical Carcinogenesis by Klaunig, James E., Xu, Yong, Isenberg, Jason S., Bachowski, Stephen, Kolaja, Kyle L., Jiang, Jiazhong, Stevenson, Donald E., Walborg, Earl F.

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A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity by Fielden, Mark R., Eynon, Barrett P., Natsoulis, Georges, Jarnagin, Kurt, Banas, Deborah, Kolaja, Kyle L.

“…One application of genomics in drug safety assessment is the identification of biomarkers to predict compound toxicity before it is detected using traditional…”
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Investigation of mechanism of drug‐induced cardiac injury and torsades de pointes in cynomolgus monkeys by Misner, DL, Frantz, C, Guo, L, Gralinski, MR, Senese, PB, Ly, J, Albassam, M, Kolaja, KL

“…BACKGROUND AND PURPOSE Drug candidates must be thoroughly investigated for their potential cardiac side effects. During the course of routine toxicological…”
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4-Hydroxynonenal and Malondialdehyde Hepatic Protein Adducts in Rats Treated with Carbon Tetrachloride: Immunochemical Detection and Lobular Localization by Hartley, Dylan P., Kolaja, Kyle L., Reichard, John, Petersen, Dennis R.

“…The metabolism of CCl4 initiates the peroxidation of polyunsaturated fatty acids producing α,β-unsaturated aldehydes, such as 4-hydroxynonenal (4-HNE) and…”
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Acute Molecular Markers of Rodent Hepatic Carcinogenesis Identified by Transcription Profiling by Kramer, Jeffrey A, Curtiss, Sandra W, Kolaja, Kyle L, Alden, Carl L, Blomme, Eric A. G, Curtiss, William C, Davila, Julio C, Jackson, Carmen J, Bunch, Roderick T

“…Currently, the only way to identify nongenotoxic hepatocarcinogens is through long-term repeat dose studies such as the 2 year rodent carcinogenicity assay…”
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Transcription Profiling Distinguishes Dose-Dependent Effects in the Livers of Rats Treated with Clofibrate by Kramer, Jeffrey A., Blomme, Eric A.G., Bunch, Roderick T., Davila, Julio C., Jackson, Carmen J., Jones, Patrick F., Kolaja, Kyle L., Curtiss, Sandra W.

“…Peroxisome proliferators such as the fibrates act via the peroxisome proliferator activated receptor (PPAR)-α as hypolipidemic agents. Many peroxisome…”
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Dose-Response Examination of UDP-Glucuronosyltransferase Inducers and Their Ability to Increase both TGF-β Expression and Thyroid Follicular Cell Apoptosis by Kolaja, Kyle L., Klaassen, Curtis D.

“…Exposure to certain microsomal enzyme inducers that increase UDP-glucuronosyltransferase (UDP-GT) activity decreases thyroid hormone levels, which may lead to…”
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Differential Display in Rat Livers Treated for 13 Weeks with Phenobarbital Implicates a Role for Metabolic and Oxidative Stress in Nongenotoxic Carcinogenicity by Elrick, Mollisa M., Kramer, Jeffrey A., Alden, Carl L., Blomme, Eric A. G., Bunch, Roderick T., Cabonce, Marc A., Curtiss, Sandra W., Kier, Larry D., Kolaja, Kyle L., Rodi, Charles P., Morris, Dale L.

“…Hepatic enzyme inducers such as phenobarbital are often nongenotoxic rodent hepatocarcinogens. Currently, nongenotoxic hepatocarcinogens can only be…”
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Dose dependence of phenobarbital promotion of preneoplastic hepatic lesions in F344 rats and B6C3F1 mice: effects on DNA synthesis and apoptosis by Kolaja, K L, Stevenson, D E, Walborg, Jr, E F, Klaunig, J E

“…Phenobarbital (PB), a non-genotoxic hepatocarcinogen in rodents, has been studied extensively but its mechanism of carcinogenic action is unclear. PB appears…”
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Inhibition of gap-junctional-intercellular communication in intact rat liver by nongenotoxic hepatocarcinogens by Kolaja, Kyle L, Engelken, Dustin T, Klaassen, Curtis D

“…Many nongenotoxic hepatocarcinogens can induce cell proliferation, and inhibit apoptosis and gap-junctional-intercellular communication (GJIC). GJIC, the…”
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Preclinical drug safety analysis by chemogenomic profiling in the liver by Fielden, Mark R, Pearson, Cecelia, Brennan, Richard, Kolaja, Kyle L

“…The economic hurdles of drug development and the emergence of genomic technologies such as chemogenomics are combining to shift the existing paradigms in…”
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Vitamin E modulation of hepatic focal lesion growth in mice by Kolaja, K.L. (Indiana University School of Medicine, Indianapolis, IN.), Klauning, J.E

“…The effect of DL-alpha-tocopherol acetate (vitamin E) on hepatic focal lesion growth in male B6C3F1 mice previously treated with diethylnitrosamine (DEN) was…”
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Inhibition of tumor promotion and hepatocellular growth by dietary restriction in mice by Kolaja, Kyle L., Bunting, Kyle A., Klaunig, James E.

“…The effects of dietary restriction on the growth of hepatic focal lesions in phenobarbital (PB) promoted mice were examined. Dietary restriction which can…”
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Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone by ISENBERG, J. S, KOLAJA, K. L, AYOUBI, S. A, WATKINS, J. B, KLAUNIG, J. E

“…The effect of rotenone treatment on [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid (WY-14,643) hepatic lesion growth in male B6C3F1 mice was…”
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Inhibition of gap-junctional-intercellular communication in thyroid-follicular cells by propylthiouracil and low iodine diet by Kolaja, Kyle L, Petrick, Jay S, Klaassen, Curtis D

“…Propylthiouracil (PTU) or low-iodine diet (LID) treatment increases thyroid-follicular-cell proliferation, possibly by disrupting the movement of small…”
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Role of oxidative stress in the mechanism of dieldrin's hepatotoxicity by Bachowski, S, Kolaja, K L, Xu, Y, Ketcham, C A, Stevenson, D E, Walborg, Jr, E F, Klaunig, J E

“…The production of reactive oxygen species (ROS) by toxic chemicals has been implicated in acute and chronic disease states, including cancer. This increase in…”
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Comparative Effects of Dieldrin on Hepatic Ploidy, Cell Proliferation, and Apoptosis in Rodent Liver by Kamendulis, Lisa M., Kolaja, Kyle L., Stevenson, Donald E., Jr, Earl F. Walborg, Klaunig, James E.

“…Dieldrin-induced hepatocarcinogenesis, which is seen only in the mouse, apparently occurs through a nongenotoxic mechanism. Previous studies have demonstrated…”
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Selective dieldrin promotion of hepatic focal lesions in mice by Kolaja, Kyte L., Stevenson, Donald E., walborg, Earl F., Klaunig, James E.

“…Chronic exposure to a number of chlorinated pesticides, including dieldrin, results in an increased and/or multiplicityof hepatocellular neoplasia in mice,…”
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