Search Results - "Kol, Arjan"

MAPK pathway activity plays a key role in PD‐L1 expression of lung adenocarcinoma cells by Stutvoet, Thijs S, Kol, Arjan, Vries, Elisabeth GE, Bruyn, Marco, Fehrmann, Rudolf SN, Terwisscha van Scheltinga, Anton GT, Jong, Steven

“…Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD‐1) and programmed death‐ligand 1 (PD‐L1) have improved the survival of patients with…”
Get full text

Combined STING levels and CD103+ T cell infiltration have significant prognostic implications for patients with cervical cancer by Kol, Arjan, Lubbers, Joyce M., Terwindt, Anouk L.J., Workel, Hagma H., Plat, Annechien, Wisman, G. Bea A., Bart, Joost, Nijman, Hans W., De Bruyn, Marco

“…Activation of STimulator of INterferon Genes (STING) is important for induction of anti-tumor immunity. A dysfunctional STING pathway is observed in multiple…”
Get full text

Development of [89Zr]Zr-hCD103.Fab01A and [68Ga]Ga-hCD103.Fab01A for PET imaging to noninvasively assess cancer reactive T cell infiltration: Fab-based CD103 immunoPET by Fan, Xiaoyu, Ważyńska, Marta A., Kol, Arjan, Perujo Holland, Noemi, Fernandes, Bruna, van Duijnhoven, Sander M. J., Plat, Annechien, van Eenennaam, Hans, Elsinga, Philip H., Nijman, Hans W., de Bruyn, Marco

“…Background CD103 is an integrin specifically expressed on the surface of cancer-reactive T cells. The number of CD103+ T cells significantly increases during…”
Get full text

Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome by Brunekreeft, Kim L., Paijens, Sterre T., Wouters, Maartje C.A., Komdeur, Fenne L., Eggink, Florine A., Lubbers, Joyce M., Workel, Hagma H., Van Der Slikke, Elisabeth C., Pröpper, Noor E.J., Leffers, Ninke, Adam, Julien, Pijper, Harry, Plat, Annechien, Kol, Arjan, Nijman, Hans W., De Bruyn, Marco

“…Epithelial Ovarian cancer (EOC) is the most lethal gynecological malignancy and has limited curative therapeutic options. Immunotherapy for EOC is promising,…”
Get full text

Development of 89Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration by Kol, Arjan, Fan, Xiaoyu, Wazynska, Marta A., van Duijnhoven, Sander M.J., Giesen, Danique, Plat, Annechien, Van Eenennaam, Hans, Elsinga, Philip H., Nijman, Hans W., de Bruyn, Marco

“…PurposeCD103, an integrin specifically expressed on the surface of cancer-reactive T cells, is significantly increased during successful immunotherapy across…”
Get full text

Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells by Hoffmann, Roland F, Zarrintan, Sina, Brandenburg, Simone M, Kol, Arjan, de Bruin, Harold G, Jafari, Shabnam, Dijk, Freark, Kalicharan, Dharamdajal, Kelders, Marco, Gosker, Harry R, Ten Hacken, Nick Ht, van der Want, Johannes J, van Oosterhout, Antoon Jm, Heijink, Irene H

“…Cigarette smoking is the major risk factor for COPD, leading to chronic airway inflammation. We hypothesized that cigarette smoke induces structural and…”
Get full text

Low-dose triple drug combination targeting the PI3K/AKT/mTOR pathway and the MAPK pathway is an effective approach in ovarian clear cell carcinoma by Caumanns, Joseph J., van Wijngaarden, Anne, Kol, Arjan, Meersma, Gert J., Jalving, Mathilde, Bernards, René, van der Zee, Ate G.J., Wisman, G. Bea A., de Jong, Steven

“…Advanced stage ovarian clear cell carcinoma (OCCC) is poorly responsive to platinum-based chemotherapy and has an unfavorable prognosis. Previous studies…”
Get full text

ADCC responses and blocking of EGFR-mediated signaling and cell growth by combining the anti-EGFR antibodies imgatuzumab and cetuximab in NSCLC cells by Kol, Arjan, Terwisscha van Scheltinga, Anton, Pool, Martin, Gerdes, Christian, de Vries, Elisabeth, de Jong, Steven

“…Imgatuzumab is a novel glycoengineered anti-epidermal growth factor receptor (EGFR) monoclonal antibody optimized to induce both antibody-dependent cellular…”
Get full text

HER3, serious partner in crime. Therapeutic approaches and potential biomarkers for effect of HER3-targeting by KOL, Arjan, VAN SCHELTINGA, Anton G. T. Terwisscha, TIMMER-BOSSCHA, Hetty, LAMBERTS, Laetitia E, BENSCH, Frederike, DE VRIES, Elisabeth G. E, SCHRÖDER, Carolina P

“…The human epidermal growth factor receptor (HER) family members are targeted by a growing numbers of small molecules and monoclonal antibodies. Resistance…”
Get full text

Molecular Imaging of PD-L1 Expression and Dynamics with the Adnectin-Based PET Tracer 18 F-BMS-986192 by Stutvoet, Thijs S, van der Veen, Elly L, Kol, Arjan, Antunes, Inês F, de Vries, Erik F J, Hospers, Geke A P, de Vries, Elisabeth G E, de Jong, Steven, Lub-de Hooge, Marjolijn N

“…F-BMS-986192, an adnectin-based human programmed cell death ligand 1 (PD-L1) tracer, was developed to noninvasively determine whole-body PD-L1 expression by…”
Get full text

Molecular Imaging of PD-L1 Expression and Dynamics with the Adnectin-Based PET Tracer 18F-BMS-986192 by Stutvoet, Thijs S, van der Veen, Elly L, Kol, Arjan, Antunes, Inês F, de Vries, Erik FJ, Hospers, Geke AP, de Vries, Elisabeth GE, de Jong, Steven, Lub-de Hooge, Marjolijn N

“…18F-BMS-986192, an adnectin-based human programmed cell death ligand 1 (PD-L1) tracer, was developed to noninvasively determine whole-body PD-L1 expression by…”
Get full text

Development of 89 Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration by Kol, Arjan, Fan, Xiaoyu, Wazynska, Marta A, van Duijnhoven, Sander M J, Giesen, Danique, Plat, Annechien, Van Eenennaam, Hans, Elsinga, Philip H, Nijman, Hans W, de Bruyn, Marco

“…CD103, an integrin specifically expressed on the surface of cancer-reactive T cells, is significantly increased during successful immunotherapy across human…”
Get full text

Expression of CD39 Identifies Activated Intratumoral CD8+ T Cells in Mismatch Repair Deficient Endometrial Cancer by Lubbers, Joyce M, Ważyńska, Marta A, van Rooij, Nienke, Kol, Arjan, Workel, Hagma H, Plat, Annechien, Paijens, Sterre T, Vlaming, Martijn R, Spierings, Diana C J, Elsinga, Philip H, Bremer, Edwin, Nijman, Hans W, de Bruyn, Marco

“…Identification of human cancer-reactive CD8+ T cells is crucial for the stratification of patients for immunotherapy and determination of immune-therapeutic…”
Get full text

Abstract 4511: Differential effects of GA201 and cetuximab on EGFR expression and endosomal recycling in non-small cell lung cancer cell lines by Kol, Arjan, Jong, Steven de, Pool, Martin, Vries, Elisabeth G.E. de, Gerdes, Christian A., Scheltinga, Anton G.T. Terwisscha van

“…Abstract GA201 is a novel glycoengineered anti-epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) that is optimized to induce both…”
Get full text

Abstract LB-B11: Assessment of HER3 status during lapatinib treatment in HER3-positive breast cancer using 89Zr-anti-HER3 mAb by Kol, Arjan, Pool, Martin, de Jong, Steven, de Vries, Elisabeth GE, Lub-de Hooge, Marjolijn N., Terwisscha van Scheltinga, Anton GT

“…Abstract Treatment of human epidermal growth factor receptor 2 (HER2)-driven breast cancer with the HER-targeting tyrosine kinase inhibitor lapatinib can lead…”
Get full text

Abstract A86: Extracellular domain shedding influences specific tumor uptake and kinetics of EGFR PET tracer 89Zr-imgatuzumab by Pool, Martin, Kol, Arjan, Lub-de Hooge, Marjolijn N., Gerdes, Christian A., de Jong, Steven, de Vries, Elisabeth G.E., Terwisscha van Scheltinga, Anton G.T.

“…Abstract Background Overexpression and mutations of epidermal growth factor receptor (EGFR) are associated with tumor cell growth, differentiation,…”
Get full text

Abstract 4931: ImmunoPET and fluorescence imaging with Zirconium-89 and IRDye 800CW labeled glycoengineered epidermal growth factor receptor antibody GA201 by Pool, Martin, Kol, Arjan, Hooge, Marjolijn N. Lub-De, Gerdes, Christian A., Jong, Steven de, Vries, Elisabeth G.E. de, Scheltinga, Anton G.T. Terwisscha van

“…Abstract Background: GA201 is a novel epidermal growth factor receptor (EGFR) monoclonal antibody (mAb), glycoengineered for enhanced antibody dependent…”
Get full text

89Zr-Onartuzumab PET imaging of c-MET receptor dynamics by Pool, Martin, Terwisscha van Scheltinga, Anton G. T., Kol, Arjan, Giesen, Danique, de Vries, Elisabeth G. E., Lub-de Hooge, Marjolijn N.

“…Purpose c-MET and its ligand hepatocyte growth factor are often dysregulated in human cancers. Dynamic changes in c-MET expression occur and might predict drug…”
Get full text

HER3, serious partner in crime by Kol, Arjan, Terwisscha van Scheltinga, Anton G.T., Timmer-Bosscha, Hetty, Lamberts, Laetitia E., Bensch, Frederike, de Vries, Elisabeth G.E., Schröder, Carolina P.

Get full text

89 Zr-mAb3481 PET for HER3 tumor status assessment during lapatinib treatment by Pool, Martin, Kol, Arjan, de Jong, Steven, de Vries, Elisabeth G E, Lub-de Hooge, Marjolijn N, Terwisscha van Scheltinga, Anton G T

“…Treatment of human epidermal growth factor receptor 2 (HER2)-driven breast cancer with tyrosine kinase inhibitor lapatinib can induce a compensatory HER3…”
Get full text