Search Results - "Kol, A."

Chronic granulomatous disease: Overview and hematopoietic stem cell transplantation by Kang, Elizabeth M., MD, Marciano, Betty E., MD, DeRavin, SukSee, MD, PhD, Zarember, Kol A., PhD, Holland, Steven M., MD, Malech, Harry L., MD

“…Chronic granulomatous disease (CGD) still causes significant morbidity and mortality. The difficulty in considering high-risk yet curative treatments, such as…”
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Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency by De Ravin, Suk See, Wu, Xiaolin, Moir, Susan, Anaya-O'Brien, Sandra, Kwatemaa, Nana, Littel, Patricia, Theobald, Narda, Choi, Uimook, Su, Ling, Marquesen, Martha, Hilligoss, Dianne, Lee, Janet, Buckner, Clarissa M, Zarember, Kol A, O'Connor, Geraldine, McVicar, Daniel, Kuhns, Douglas, Throm, Robert E, Zhou, Sheng, Notarangelo, Luigi D, Hanson, I Celine, Cowan, Mort J, Kang, Elizabeth, Hadigan, Coleen, Meagher, Michael, Gray, John T, Sorrentino, Brian P, Malech, Harry L, Kardava, Lela

“…X-linked severe combined immunodeficiency (SCID-X1) is a profound deficiency of T, B, and natural killer (NK) cell immunity caused by mutations inIL2RGencoding…”
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CRISPR-Cas9 gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease by De Ravin, Suk See, Li, Linhong, Wu, Xiaolin, Choi, Uimook, Allen, Cornell, Koontz, Sherry, Lee, Janet, Theobald-Whiting, Narda, Chu, Jessica, Garofalo, Mary, Sweeney, Colin, Kardava, Lela, Moir, Susan, Viley, Angelia, Natarajan, Pachai, Su, Ling, Kuhns, Douglas, Zarember, Kol A, Peshwa, Madhusudan V, Malech, Harry L

“…Gene repair of CD34 hematopoietic stem and progenitor cells (HSPCs) may avoid problems associated with gene therapy, such as vector-related mutagenesis and…”
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Isolation and Functional Analysis of Human Neutrophils by Kuhns, Douglas B, Priel, Debra A Long, Chu, Jessica, Zarember, Kol A

“…This unit describes the isolation of human polymorphonuclear neutrophils (PMN) from blood using dextran sedimentation and Percoll or Ficoll-Paque density…”
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Th17 Pathway As a Target for Multipotent Stromal Cell Therapy in Dogs: Implications for Translational Research by Kol, A, Walker, N J, Nordstrom, M, Borjesson, D L

“…Detrimental Th17 driven inflammatory and autoimmune disease such as Crohn's disease, graft versus host disease and multiple sclerosis remain a significant…”
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Targeted gene addition in human CD34+ hematopoietic cells for correction of X-linked chronic granulomatous disease by De Ravin, Suk See, Reik, Andreas, Liu, Pei-Qi, Li, Linhong, Wu, Xiaolin, Su, Ling, Raley, Castle, Theobald, Narda, Choi, Uimook, Song, Alexander H, Chan, Andy, Pearl, Jocelynn R, Paschon, David E, Lee, Janet, Newcombe, Hannah, Koontz, Sherry, Sweeney, Colin, Shivak, David A, Zarember, Kol A, Peshwa, Madhusudan V, Gregory, Philip D, Urnov, Fyodor D, Malech, Harry L

“…Targeted genetic correction of hematopoietic stem cells is applied to X-linked chronic granulomatous disease. Gene therapy with genetically modified human CD34…”
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Residual NADPH Oxidase and Survival in Chronic Granulomatous Disease by Kuhns, Douglas B, Alvord, W. Gregory, Heller, Theo, Feld, Jordan J, Pike, Kristen M, Marciano, Beatriz E, Uzel, Gulbu, DeRavin, Suk See, Priel, Debra A. Long, Soule, Benjamin P, Zarember, Kol A, Malech, Harry L, Holland, Steven M, Gallin, John I

“…Survival in chronic granulomatous disease is related to the level of NADPH oxidase activity, which correlates with the altered site on the mutated gene…”
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Immunopathogenesis of canine chronic ulcerative stomatitis by Anderson, J G, Kol, A, Bizikova, P, Stapelton, B P, Ford, K, Villarreal, A, Jimenez, R J, Vasilatis, D, Murphy, B G

“…Canine Chronic Ulcerative Stomatitis is a spontaneously occurring inflammatory disease of the oral mucosa. An immune-mediated pathogenesis is suspected though…”
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Cytoskeletal abnormalities and neutrophil dysfunction in WDR1 deficiency by Kuhns, Douglas B., Fink, Danielle L., Choi, Uimook, Sweeney, Colin, Lau, Karen, Priel, Debra Long, Riva, Dara, Mendez, Laura, Uzel, Gulbu, Freeman, Alexandra F., Olivier, Kenneth N., Anderson, Victoria L., Currens, Robin, Mackley, Vanessa, Kang, Allison, Al-Adeli, Mehdi, Mace, Emily, Orange, Jordan S., Kang, Elizabeth, Lockett, Stephen J., Chen, De, Steinbach, Peter J., Hsu, Amy P., Zarember, Kol A., Malech, Harry L., Gallin, John I., Holland, Steven M.

“…Cell motility, division, and structural integrity depend on dynamic remodeling of the cellular cytoskeleton, which is regulated in part by actin polymerization…”
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TNF overproduction impairs epithelial staphylococcal response in hyper IgE syndrome by Myles, Ian A, Anderson, Erik D, Earland, Noah J, Zarember, Kol A, Sastalla, Inka, Williams, Kelli W, Gough, Portia, Moore, Ian N, Ganesan, Sundar, Fowler, Cedar J, Laurence, Arian, Garofalo, Mary, Kuhns, Douglas B, Kieh, Mark D, Saleem, Arhum, Welch, Pamela A, Darnell, Dirk A, Gallin, John I, Freeman, Alexandra F, Holland, Steven M, Datta, Sandip K

“…Autosomal dominant hyper IgE syndrome (AD-HIES), or Job's syndrome, is a primary immune deficiency caused by dominant-negative mutations in STAT3. Recurrent…”
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Genes differentially expressed in conidia and hyphae of Aspergillus fumigatus upon exposure to human neutrophils by Sugui, Janyce A, Kim, H Stanley, Zarember, Kol A, Chang, Yun C, Gallin, John I, Nierman, Willian C, Kwon-Chung, Kyung J

“…Aspergillus fumigatus is the most common etiologic agent of invasive aspergillosis in immunocompromised patients. Several studies have addressed the mechanism…”
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Granulibacter bethesdensis , a Pathogen from Patients with Chronic Granulomatous Disease, Produces a Penta-Acylated Hypostimulatory Glycero-D-talo-oct-2-ulosonic Acid-Lipid A Glycolipid (Ko-Lipid A) by Muszyński, Artur, Zarember, Kol A, Heiss, Christian, Shiloach, Joseph, Berg, Lars J, Audley, John, Kozyr, Arina, Greenberg, David E, Holland, Steven M, Malech, Harry L, Azadi, Parastoo, Carlson, Russell W, Gallin, John I

“…can infect patients with chronic granulomatous disease, an immunodeficiency caused by reduced phagocyte NADPH oxidase function. Intact ( ) is hypostimulatory…”
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Gliotoxin Is a Virulence Factor of Aspergillus fumigatus: gliP Deletion Attenuates Virulence in Mice Immunosuppressed with Hydrocortisone by Sugui, Janyce A, Pardo, Julian, Chang, Yun C, Zarember, Kol A, Nardone, Glenn, Galvez, Eva M, Müllbacher, Arno, Gallin, John I, Simon, Markus M, Kwon-Chung, Kyung J

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Hypomorphic Rag mutations can cause destructive midline granulomatous disease by De Ravin, Suk See, Cowen, Edward W., Zarember, Kol A., Whiting-Theobald, Narda L., Kuhns, Douglas B., Sandler, Netanya G., Douek, Daniel C., Pittaluga, Stefania, Poliani, Pietro L., Lee, Yu Nee, Notarangelo, Luigi D., Wang, Lei, Alt, Frederick W., Kang, Elizabeth M., Milner, Joshua D., Niemela, Julie E., Fontana-Penn, Mary, Sinal, Sara H., Malech, Harry L.

“…Destructive midline granulomatous disease characterized by necrotizing granulomas of the head and neck is most commonly caused by Wegener granulomatosis,…”
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Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury by Mason, Hannah, Rai, Ganesha, Kozyr, Arina, De Jonge, Nathaniel, Gliniewicz, Emily, Berg, Lars J., Wald, Gal, Dorrier, Cayce, Henderson, Mark J., Zakharov, Alexey, Dyson, Tristan, Audley, John, Pettinato, Anthony M., Padilha, Elias Carvalho, Shah, Pranav, Xu, Xin, Leto, Thomas L., Simeonov, Anton, Zarember, Kol A., McGavern, Dorian B., Gallin, John I.

“…NADPH oxidases (NOX's), and the reactive oxygen species (ROS) they produce, play an important role in host defense, thyroid hormone synthesis, apoptosis, gene…”
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Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines by Zarember, Kol A, Godowski, Paul J

“…Members of the Toll-like receptor (TLR) family mediate dorsoventral patterning and cellular adhesion in insects as well as immune responses to microbial…”
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An AAVS1-Targeted Minigene Platform for Correction of iPSCs From All Five Types of Chronic Granulomatous Disease by Merling, Randall K, Sweeney, Colin L, Chu, Jessica, Bodansky, Aaron, Choi, Uimook, Priel, Debra Long, Kuhns, Douglas B, Wang, Hongmei, Vasilevsky, Sam, De Ravin, Suk See, Winkler, Thomas, Dunbar, Cynthia E, Zou, Jizhong, Zarember, Kol A, Gallin, John I, Holland, Steven M, Malech, Harry L

“…There are five genetic forms of chronic granulomatous disease (CGD), resulting from mutations in any of five subunits of phagocyte oxidase, an enzyme complex…”
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Antifungal Activities of Natural and Synthetic Iron Chelators Alone and in Combination with Azole and Polyene Antibiotics against Aspergillus fumigatus by ZAREMBER, Kol A, CRUZ, Anna R, HUANG, Chiung-Yu, GAILIN, John I

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Human Polymorphonuclear Leukocytes Inhibit Aspergillus fumigatus Conidial Growth by Lactoferrin-Mediated Iron Depletion by Zarember, Kol A, Sugui, Janyce A, Chang, Yun C, Kwon-Chung, Kyung J, Gallin, John I

“…Aspergillus fumigatus, a common mold, rarely infects humans, except during prolonged neutropenia or in cases of chronic granulomatous disease (CGD), a primary…”
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Can montelukast sodium be an alternative treatment in the treatment of interstitial cystitis? by Gunizi, O, Kol, A, Gunizi, H

“…Background: The leukotriene D4 receptors have been detected in human bladder detrusor myocytes, and they can play the role of interstitial cystitis etiology…”
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