Genetic Controls of Susceptibility and Resistance to 4‐Nitroquinoline 1‐Oxide‐induced Tongue Carcinomas in Rats

Genetic Controls of Susceptibility and Resistance to 4‐Nitroquinoline 1‐Oxide‐induced Tongue Carcinomas in Rats

We analyzed the incidence of infiltrative mass‐type tongue carcinomas (IMTC) induced in 550 rats by continuous oral administration of 0.001% 4‐nitroquinoline 1‐oxide solution for 180 days. The study included various crosses of susceptible Dark‐Agouti rats (DA) and resistant Wistar/Furth rats (WF). D...

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Bibliographic Details
Published in:Japanese Journal of Cancer Research Vol. 87; no. 11; pp. 1097 - 1101
Main Authors: Kitano, Motoo, Hirayama, Yoshikazu, Tanuma, Jun‐ichi, Matsuuchi, Hiroaki, Miura, Yoshihiro, Li, Tie‐Jun, Semba, Ichiro, Ozaki, Hiroki S., Kokubu, Teiji, Hatano, Hiromichi, Tada, Mariko, Kobayashi, Yasuto, Shisa, Hayase
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Publishing Ltd 01-11-1996
Japanese Cancer Association
Subjects:
4-Nitroquinoline-1-oxide - toxicity
4‐Nitroquinoline 1‐oxide
Animals
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Carcinogens - toxicity
Chemical agents
Cocarcinogenesis
Disease Susceptibility
Drug Resistance, Neoplasm
Female
Genetic control
Male
Medical sciences
Rats
Rats, Inbred WF
Resistance
Susceptibility
Tongue carcinoma
Tongue Neoplasms - chemically induced
Tongue Neoplasms - genetics
Tumors
Tongue
Carcinoma
Genetic inheritance
Rat
Stomatology
Rodentia
Malignant tumor
Infiltrating tumor
Carcinogenesis
Carcinogen
Vertebrata
Experimental disease
Mammalia
Animal
Predisposition
Genetics
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Description
Summary:We analyzed the incidence of infiltrative mass‐type tongue carcinomas (IMTC) induced in 550 rats by continuous oral administration of 0.001% 4‐nitroquinoline 1‐oxide solution for 180 days. The study included various crosses of susceptible Dark‐Agouti rats (DA) and resistant Wistar/Furth rats (WF). DA showed a 93.6% incidence of IMTC measuring more than 5 mm in their largest diameter, while WF showed only a 4% incidence. Reciprocal F1 and F2 hybrids mated by DA and WF showed 47.5% and 45.8% incidences, respectively. Meanwhile, reciprocal backcrossed hybrids to DA and WF showed 73.7%, and 24.6% incidences, respectively. Segregation of the incidences suggests that there are two autosomal dominant genes, one linked to the susceptibility of DA and the other to the resistance of WF.
ISSN:0910-5050
1349-7006
1876-4673
DOI:10.1111/j.1349-7006.1996.tb03116.x