Search Results - "Kokotos, Alexandros C."

VAMP4 Is an Essential Cargo Molecule for Activity-Dependent Bulk Endocytosis by Nicholson-Fish, Jessica C., Kokotos, Alexandros C., Gillingwater, Thomas H., Smillie, Karen J., Cousin, Michael A.

“…The accurate formation of synaptic vesicles (SVs) and incorporation of their protein cargo during endocytosis is critical for the maintenance of…”
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Synaptic Vesicle Generation from Central Nerve Terminal Endosomes by Kokotos, Alexandros C., Cousin, Michael A.

“…Central nerve terminals contain a small number of synaptic vesicles (SVs) that must sustain the fidelity of neurotransmission across a wide range of…”
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The arrestin‐like protein ArtA is essential for ubiquitination and endocytosis of the UapA transporter in response to both broad‐range and specific signals by Karachaliou, Mayia, Amillis, Sotiris, Evangelinos, Minoas, Kokotos, Alexandros C., Yalelis, Vassilis, Diallinas, George

“…Summary We investigated the role of all arrestin‐like proteins of Aspergillus nidulans in respect to growth, morphology, sensitivity to drugs and specifically…”
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A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes by Peiris, Heshan, Duffield, Michael D, Fadista, Joao, Jessup, Claire F, Kashmir, Vinder, Genders, Amanda J, McGee, Sean L, Martin, Alyce M, Saiedi, Madiha, Morton, Nicholas, Carter, Roderick, Cousin, Michael A, Kokotos, Alexandros C, Oskolkov, Nikolay, Volkov, Petr, Hough, Tertius A, Fisher, Elizabeth M C, Tybulewicz, Victor L J, Busciglio, Jorge, Coskun, Pinar E, Becker, Ann, Belichenko, Pavel V, Mobley, William C, Ryan, Michael T, Chan, Jeng Yie, Laybutt, D Ross, Coates, P Toby, Yang, Sijun, Ling, Charlotte, Groop, Leif, Pritchard, Melanie A, Keating, Damien J

“…Type 2 diabetes (T2D) is a complex metabolic disease associated with obesity, insulin resistance and hypoinsulinemia due to pancreatic β-cell dysfunction…”
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iATPSnFR2: A high-dynamic-range fluorescent sensor for monitoring intracellular ATP by Marvin, Jonathan S, Kokotos, Alexandros C, Kumar, Mukesh, Pulido, Camila, Tkachuk, Ariana N, Yao, Jocelyn Shuxin, Brown, Timothy A, Ryan, Timothy A

“…We developed a significantly improved genetically encoded quantitative adenosine triphosphate (ATP) sensor to provide real-time dynamics of ATP levels in…”
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Saturated Hydroxy Fatty Acids Exhibit a Cell Growth Inhibitory Activity and Suppress the Cytokine-Induced β‑Cell Apoptosis by Kokotou, Maroula G, Kokotos, Alexandros C, Gkikas, Dimitrios, Mountanea, Olga G, Mantzourani, Christiana, Almutairi, Abdulaziz, Lei, Xiaoyong, Ramanadham, Sasanka, Politis, Panagiotis K, Kokotos, George

“…The field of bioactive lipids is ever expanding with discoveries of novel lipid molecules that promote human health. Adopting a lipidomic-assisted approach,…”
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Synaptophysin sustains presynaptic performance by preserving vesicular synaptobrevin‐II levels by Kokotos, Alexandros C., Harper, Callista B., Marland, Jamie R.K., Smillie, Karen J., Cousin, Michael A., Gordon, Sarah L.

“…The two most abundant molecules on synaptic vesicles (SVs) are synaptophysin and synaptobrevin‐II (sybII). SybII is essential for SV fusion, whereas…”
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N‑(2-Aminophenyl)-benzamide Inhibitors of Class I HDAC Enzymes with Antiproliferative and Antifibrotic Activity by Gerokonstantis, Dimitrios Triantafyllos, Mantzourani, Christiana, Gkikas, Dimitrios, Wu, Kai-Chen, Hoang, Huy N., Triandafillidi, Ierasia, Barbayianni, Ilianna, Kanellopoulou, Paraskevi, Kokotos, Alexandros C., Moutevelis-Minakakis, Panagiota, Aidinis, Vassilis, Politis, Panagiotis K., Fairlie, David P., Kokotos, George

“…Inhibitors of histone deacetylases (HDACs) have received special attention as novel anticancer agents. Among various types of synthetic inhibitors, benzamides…”
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Myosin II and dynamin control actin rings to mediate fission during activity-dependent bulk endocytosis by Kokotos, Alexandros C, Low, Darryl W

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Phosphoglycerate kinase is a central leverage point in Parkinson's disease-driven neuronal metabolic deficits by Kokotos, Alexandros C, Antoniazzi, Aldana M, Unda, Santiago R, Ko, Myung Soo, Park, Daehun, Eliezer, David, Kaplitt, Michael G, De Camilli, Pietro, Ryan, Timothy A

“…Although certain drivers of familial Parkinson's disease (PD) compromise mitochondrial integrity, whether metabolic deficits underly other idiopathic or…”
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A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to [beta]-Cell Mitochondrial Dysfunction in Type 2 Diabetes by Peiris, Heshan, Duffield, Michael D, Fadista, Joao, Jessup, Claire F, Kashmir, Vinder, Genders, Amanda J, McGee, Sean L, Martin, Alyce M, Saiedi, Madiha, Morton, Nicholas, Carter, Roderick, Cousin, Michael A, Kokotos, Alexandros C, Oskolkov, Nikolay, Volkov, Petr, Hough, Tertius A, Fisher, Elizabeth M. C, Tybulewicz, Victor L. J, Busciglio, Jorge, Coskun, Pinar E, Becker, Ann, Belichenko, Pavel V, Mobley, William C, Ryan, Michael T, Chan, Jeng Yie, Laybutt, D. Ross, Coates, P. Toby, Yang, Sijun, Ling, Charlotte, Groop, Leif, Pritchard, Melanie A, Keating, Damien J

“…Type 2 diabetes (T2D) is a complex metabolic disease associated with obesity, insulin resistance and hypoinsulinemia due to pancreatic [beta]-cell dysfunction…”
Get full text