Search Results - "Kokkoni, Nicoleta"

N-Methylated Peptide Inhibitors of β-Amyloid Aggregation and Toxicity. Optimization of the Inhibitor Structure by Kokkoni, Nicoleta, Stott, Kelvin, Amijee, Hozefa, Mason, Jody M, Doig, Andrew J

“…The key pathogenic event in the onset of Alzheimer's disease (AD) is believed to be the aggregation of the β-amyloid (Aβ) peptide into toxic oligomers…”
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Design strategies for anti-amyloid agents by Mason, Jody M, Kokkoni, Nicoleta, Stott, Kelvin, Doig, Andrew J

“…Numerous diseases have been linked to a common pathogenic process called amyloidosis, whereby proteins or peptides clump together in the brain or body to form…”
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Stabilizing Interactions between Aromatic and Basic Side Chains in α-Helical Peptides and Proteins. Tyrosine Effects on Helix Circular Dichroism by Andrew, Charles D, Bhattacharjee, Samita, Kokkoni, Nicoleta, Hirst, Jonathan D, Jones, Gareth R, Doig, Andrew J

“…Here we investigate the structures and energetics of interactions between aromatic (Phe or Tyr) and basic (Lys or Arg) amino acids in α-helices. Side chain…”
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P4-300: N-methylated peptide inhibitors of β-amyloid aggregation by Doig, Andrew, Kokkoni, Nicoleta, Stott, Kelvin, Amijee, Hozefa, Bottomley, Joanna, Mason, Jody, Treherne, Mark, Scopes, David

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N-methylated peptides for the treatment of alzheimer's disease and type ii diabetes by Kokkoni, Nicoleta

“…In this study N-methylated peptides were designed to inhibit and reverse the Aβ(1-40)/Aβ(1-42) and IAPP(1-37) peptide aggregation as well as their associated…”
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