Search Results - "Kokkonen, Nina"

BP180/Collagen XVII: A Molecular View by Tuusa, Jussi, Kokkonen, Nina, Tasanen, Kaisa

“…BP180 is a type II collagenous transmembrane protein and is best known as the major autoantigen in the blistering skin disease bullous pemphigoid (BP). The…”
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Elevated Golgi pH impairs terminal N-glycosylation by inducing mislocalization of Golgi glycosyltransferases by Rivinoja, Antti, Hassinen, Antti, Kokkonen, Nina, Kauppila, Annika, Kellokumpu, Sakari

“…Acidic pH of the Golgi lumen is known to be crucial for correct glycosylation, transport and sorting of proteins and lipids during their transit through the…”
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Gliptin-associated Bullous Pemphigoid and the Expression of Dipeptidyl Peptidase-4/CD26 in Bullous Pemphigoid by Lindgren, Outi, Varpuluoma, Outi, Tuusa, Jussi, Ilonen, Jorma, Huilaja, Laura, Kokkonen, Nina, Tasanen, Kaisa

“…Dipeptidyl peptidase-4 inhibitors (DPP-4i or gliptins) increase the risk of developing bullous pemphigoid (BP). To clarify, whether gliptin-associated BP has…”
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Use of gliptins reduces levels of SDF-1/CXCL12 in bullous pemphigoid and type 2 diabetes, but does not increase autoantibodies against BP180 in diabetic patients by Nätynki, Antti, Leisti, Päivi, Tuusa, Jussi, Varpuluoma, Outi, Huilaja, Laura, Izumi, Kentaro, Herukka, Sanna-Kaisa, Ukkola, Olavi, Junttila, Juhani, Kokkonen, Nina, Tasanen, Kaisa

“…The use of dipeptidyl peptidase 4 (DPP4) inhibitors, (also known as gliptins), is associated with an increased risk of bullous pemphigoid (BP), an autoimmune…”
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Significant Role of Collagen XVII And Integrin β4 in Migration and Invasion of The Less Aggressive Squamous Cell Carcinoma Cells by Moilanen, Jyri M., Löffek, Stefanie, Kokkonen, Nina, Salo, Sirpa, Väyrynen, Juha P., Hurskainen, Tiina, Manninen, Aki, Riihilä, Pilvi, Heljasvaara, Ritva, Franzke, Claus-Werner, Kähäri, Veli-Matti, Salo, Tuula, Mäkinen, Markus J., Tasanen, Kaisa

“…Collagen XVII and integrin α6β4 have well-established roles as epithelial adhesion molecules. Their binding partner laminin 332 as well as integrin α6β4 are…”
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Autoantibodies Against the Immunodominant Bullous Pemphigoid Epitopes Are Rare in Patients With Dermatitis Herpetiformis and Coeliac Disease by Nätynki, Antti, Tuusa, Jussi, Hervonen, Kaisa, Kaukinen, Katri, Lindgren, Outi, Huilaja, Laura, Kokkonen, Nina, Salmi, Teea, Tasanen, Kaisa

“…Dermatitis herpetiformis (DH) is an extraintestinal manifestation of coeliac disease (CD). Patients with DH have an elevated risk of development of another…”
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Collagen XVII expression correlates with the invasion and metastasis of colorectal cancer by Moilanen, Jyri M., MD, Kokkonen, Nina, PhD, Löffek, Stefanie, PhD, Väyrynen, Juha P., MD, PhD, Syväniemi, Erkki, MD, Hurskainen, Tiina, PhD, Mäkinen, Markus, MD, PhD, Klintrup, Kai, MD, PhD, Mäkelä, Jyrki, MD, PhD, Sormunen, Raija, PhD, Bruckner-Tuderman, Leena, MD, PhD, Autio-Harmainen, Helena, MD, PhD, Tasanen, Kaisa, MD, PhD

“…Summary Collagen XVII has a well-established role as an adhesion molecule and a cell surface receptor located in the type I hemidesmosome of stratified…”
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Defective Acidification of Intracellular Organelles Results in Aberrant Secretion of Cathepsin D in Cancer Cells by Kokkonen, Nina, Rivinoja, Antti, Kauppila, Annika, Suokas, Marko, Kellokumpu, Ilmo, Kellokumpu, Sakari

“…Aberrant secretion of lysosomal hydrolases such as (pro)cathepsin D (proCD) is a common phenotypic change in many human cancers. Here we explore the underlying…”
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Absence of NC14A Domain of COLXVII/BP180 in Mice Results in IL-17‒Associated Skin Inflammation by Lindgren, Outi, Le Menn, Gwenaëlle, Tuusa, Jussi, Chen, Zhi Jane, Tasanen, Kaisa, Kokkonen, Nina

“…The deletion of exon 18 from Col17a1 in transgenic ΔNC14A mice results in the absence of the NC14A domain. NC14A corresponds to the human NC16A domain, the…”
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Proteomic changes related to actin cytoskeleton function in the skin of vildagliptin-treated mice by Nätynki, Antti, Kokkonen, Nina, Tuusa, Jussi, Ohlmeier, Steffen, Bergmann, Ulrich, Tasanen, Kaisa

“…Vildagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4i) is a widely used type 2 diabetes medication that is associated with an up-to 10-fold increased risk…”
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Abnormal Golgi pH Homeostasis in Cancer Cells Impairs Apical Targeting of Carcinoembryonic Antigen by Inhibiting Its Glycosyl-Phosphatidylinositol Anchor-Mediated Association with Lipid Rafts by Kokkonen, Nina, Khosrowabadi, Elham, Hassinen, Antti, Harrus, Deborah, Glumoff, Tuomo, Kietzmann, Thomas, Kellokumpu, Sakari

“…Carcinoembryonic antigen (CEACAM5, CEA) is a known tumor marker for colorectal cancer that localizes in a polarized manner to the apical surface in normal…”
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Dipeptidyl Peptidase 4 Inhibitor‒Associated Bullous Pemphigoid Is Characterized by an Altered Expression of Cytokines in the Skin by Tuusa, Jussi, Kokkonen, Nina, Mattila, Anja, Huilaja, Laura, Varpuluoma, Outi, Rannikko, Sirpa, Glumoff, Virpi, Miettunen, Jouko, Tasanen, Kaisa

“…Dipeptidyl peptidase 4 inhibitors (DPP4is), commonly used drugs for treatment of type 2 diabetes, increase the risk for bullous pemphigoid (BP). Currently, the…”
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Functional Organization of Golgi N- and O-Glycosylation Pathways Involves pH-dependent Complex Formation That Is Impaired in Cancer Cells by Hassinen, Antti, Pujol, Francois M., Kokkonen, Nina, Pieters, Caroline, Kihlström, Minna, Korhonen, Kati, Kellokumpu, Sakari

“…Glycosylation is one of the most common modifications of proteins and lipids and also a major source of biological diversity in eukaryotes. It is critical for…”
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Increased Levels of the Bullous Pemphigoid BP180 Autoantibody Are Associated with More Severe Dementia in Alzheimer’s Disease by Kokkonen, Nina, Herukka, Sanna-Kaisa, Huilaja, Laura, Kokki, Merja, Koivisto, Anne M., Hartikainen, Päivi, Remes, Anne M., Tasanen, Kaisa

“…Bullous pemphigoid (BP) is a subepidermal blistering skin disease, which has shown a strong association with neurological diseases in epidemiological studies…”
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BP180 Autoantibodies Target Different Epitopes in Multiple Sclerosis or Alzheimer’s Disease than in Bullous Pemphigoid by Tuusa, Jussi, Lindgren, Outi, Tertsunen, Hanna-Mari, Nishie, Wataru, Kokkonen, Nina, Huilaja, Laura, Izumi, Kentaro, Herukka, Sanna-Kaisa, Miettunen, Jouko, Shimizu, Hiroshi, Remes, Anne M., Tasanen, Kaisa

“…Neurologic patients have an increased risk for bullous pemphigoid (BP), in which autoantibodies target BP180, a cutaneous basement membrane protein also…”
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Deletion of the Major Bullous Pemphigoid Epitope Region of Collagen XVII Induces Blistering, Autoimmunization, and Itching in Mice by Hurskainen, Tiina, Kokkonen, Nina, Sormunen, Raija, Jackow, Joanna, Löffek, Stefanie, Soininen, Raija, Franzke, Claus-Werner, Bruckner-Tuderman, Leena, Tasanen, Kaisa

“…Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering skin disease with a characteristic of pruritus and blistering. BP patients carry…”
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Elevated Golgi pH in breast and colorectal cancer cells correlates with the expression of oncofetal carbohydrate T-antigen by Rivinoja, Antti, Kokkonen, Nina, Kellokumpu, Ilmo, Kellokumpu, Sakari

“…Altered glycosylation has turned out to be a universal feature of cancer cells, and in many cases, to correlate with altered expression or localization of…”
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Clinical Efficiency of Topical Calcipotriol/Betamethasone Treatment in Psoriasis Relies on Suppression of the Inflammatory TNFα - IL-23 - IL-17 Axis by Kubin, Minna E, Kokkonen, Nina, Palatsi, Riitta, Hägg, Päivi M, Väyrynen, Juha P, Glumoff, Virpi, Haapasaari, Kirsi-Maria, Hurskainen, Tiina, Tasanen, Kaisa

“…The effects of topical calcipotriol/betamethasone combination therapy and betamethasone monotherapy on inflammatory T-cell numbers and molecular markers were…”
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The Association Between Frontotemporal Lobar Degeneration and Bullous Pemphigoid by Katisko, Kasper, Kokkonen, Nina, Krüger, Johanna, Hartikainen, Päivi, Koivisto, Anne M, Helisalmi, Seppo, Korhonen, Ville E, Kokki, Merja, Tuusa, Jussi, Herukka, Sanna-Kaisa, Solje, Eino, Haapasalo, Annakaisa, Tasanen, Kaisa, Remes, Anne M

“…Recent studies have shown an epidemiological and immunological association between bullous pemphigoid (BP) and several neurological or psychiatric diseases…”
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Glucocorticoid receptors GRα and GRβ are expressed in inflammatory dermatoses by Kubin, Minna E., Hägg, Päivi M., Kokkonen, Nina, Väyrynen, Juha P., Haapasaari, Kirsi-Maria, Moilanen, Jyri, Kallioinen, Matti, Hurskainen, Tiina, Tasanen, Kaisa

“…Background Glucocorticoids (GC) are the most commonly used antiinflammatory drugs in dermatology. The actions of GCs are mediated by the glucocorticoid…”
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