Search Results - "Kokiko‐cochran, Olga N"

Traumatic brain injury‐induced neuronal damage in the somatosensory cortex causes formation of rod‐shaped microglia that promote astrogliosis and persistent neuroinflammation by Witcher, Kristina G., Bray, Chelsea E., Dziabis, Julia E., McKim, Daniel B., Benner, Brooke N., Rowe, Rachel K., Kokiko‐Cochran, Olga N., Popovich, Phillip G., Lifshitz, Jonathan, Eiferman, Daniel S., Godbout, Jonathan P.

“…Microglia undergo dynamic structural and transcriptional changes during the immune response to traumatic brain injury (TBI). For example, TBI causes microglia…”
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Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain by Maphis, Nicole, Xu, Guixiang, Kokiko-Cochran, Olga N, Jiang, Shanya, Cardona, Astrid, Ransohoff, Richard M, Lamb, Bruce T, Bhaskar, Kiran

“…Pathological aggregation of tau is a hallmark of Alzheimer's disease and related tauopathies. We have previously shown that the deficiency of the microglial…”
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Traumatic Brain Injury Causes Chronic Cortical Inflammation and Neuronal Dysfunction Mediated by Microglia by Witcher, Kristina G, Bray, Chelsea E, Chunchai, Titikorn, Zhao, Fangli, O'Neil, Shane M, Gordillo, Alan J, Campbell, Warren A, McKim, Daniel B, Liu, Xiaoyu, Dziabis, Julia E, Quan, Ning, Eiferman, Daniel S, Fischer, Andy J, Kokiko-Cochran, Olga N, Askwith, Candice, Godbout, Jonathan P

“…Traumatic brain injury (TBI) can lead to significant neuropsychiatric problems and neurodegenerative pathologies, which develop and persist years after injury…”
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The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer's Disease by Kokiko-Cochran, Olga N, Godbout, Jonathan P

“…The post-injury inflammatory response is a key mediator in long-term recovery from traumatic brain injury (TBI). Moreover, the immune response to TBI, mediated…”
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Deplete and repeat: microglial CSF1R inhibition and traumatic brain injury by Boland, Rebecca, Kokiko-Cochran, Olga N

“…Traumatic brain injury (TBI) is a public health burden affecting millions of people. Sustained neuroinflammation after TBI is often associated with poor…”
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Regulation of Tau Pathology by the Microglial Fractalkine Receptor by Bhaskar, Kiran, Konerth, Megan, Kokiko-Cochran, Olga N., Cardona, Astrid, Ransohoff, Richard M., Lamb, Bruce T.

“…Aggregates of the hyperphosphorylated microtubule-associated protein tau (MAPT) are an invariant neuropathological feature of tauopathies. Here, we show that…”
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TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy by Bemiller, Shane M, McCray, Tyler J, Allan, Kevin, Formica, Shane V, Xu, Guixiang, Wilson, Gina, Kokiko-Cochran, Olga N, Crish, Samuel D, Lasagna-Reeves, Cristian A, Ransohoff, Richard M, Landreth, Gary E, Lamb, Bruce T

“…Genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) confer increased risk of developing late-onset Alzheimer's Disease (LOAD) and…”
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A Tilted Axis: Maladaptive Inflammation and HPA Axis Dysfunction Contribute to Consequences of TBI by Tapp, Zoe M, Godbout, Jonathan P, Kokiko-Cochran, Olga N

“…Each year approximately 1.7 million people sustain a traumatic brain injury (TBI) in the US alone. Associated with these head injuries is a high prevalence of…”
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A Levee to the Flood: Pre-injury Neuroinflammation and Immune Stress Influence Traumatic Brain Injury Outcome by Houle, Samuel, Kokiko-Cochran, Olga N

“…Increasing evidence demonstrates that aging influences the brain's response to traumatic brain injury (TBI), setting the stage for neurodegenerative pathology…”
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Context is key: glucocorticoid receptor and corticosteroid therapeutics in outcomes after traumatic brain injury by Taylor, Morgan A, Kokiko-Cochran, Olga N

“…Traumatic brain injury (TBI) is a global health burden, and survivors suffer functional and psychiatric consequences that can persist long after injury. TBI…”
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Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events by Bhaskar, Kiran, Maphis, Nicole, Xu, Guixiang, Varvel, Nicholas H, Kokiko-Cochran, Olga N, Weick, Jason P, Staugaitis, Susan M, Cardona, Astrid, Ransohoff, Richard M, Herrup, Karl, Lamb, Bruce T

“…Abstract Massive neuronal loss is a key pathological hallmark of Alzheimer's disease (AD). However, the mechanisms are still unclear. Here we demonstrate that…”
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Traumatic Brain Injury in hTau Model Mice: Enhanced Acute Macrophage Response and Altered Long-Term Recovery by Kokiko-Cochran, Olga N, Saber, Maha, Puntambekar, Shweta, Bemiller, Shane M, Katsumoto, Atsuko, Lee, Yu-Shang, Bhaskar, Kiran, Ransohoff, Richard M, Lamb, Bruce T

“…Traumatic brain injury (TBI) induces widespread neuroinflammation and accumulation of microtubule associated protein tau (MAPT): two key pathological features…”
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Lateral Fluid Percussion Injury Causes Sex-Specific Deficits in Anterograde but Not Retrograde Memory by Fitzgerald, Julie, Houle, Samuel, Cotter, Christopher, Zimomra, Zachary, Martens, Kris M, Vonder Haar, Cole, Kokiko-Cochran, Olga N

“…Cognitive impairment is a common symptom after traumatic brain injury (TBI). Memory, in particular, is often disrupted during chronic post-injury recovery. To…”
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Robust Transcriptional Profiling and Identification of Differentially Expressed Genes With Low Input RNA Sequencing of Adult Hippocampal Neural Stem and Progenitor Populations by Denninger, Jiyeon K, Walker, Logan A, Chen, Xi, Turkoglu, Altan, Pan, Alex, Tapp, Zoe, Senthilvelan, Sakthi, Rindani, Raina, Kokiko-Cochran, Olga N, Bundschuh, Ralf, Yan, Pearlly, Kirby, Elizabeth D

“…Multipotent neural stem cells (NSCs) are found in several isolated niches of the adult mammalian brain where they have unique potential to assist in tissue…”
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DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer's disease by Daily, Kylene P, Badr, Asmaa, Eltobgy, Mostafa, Estfanous, Shady, Whitham, Owen, Tan, Michelle H, Carafice, Cierra, Krause, Kathrin, McNamara, Andrew, Hamilton, Kaitlin, Houle, Samuel, Gupta, Spandan, Gupta, Gauruv A, Madhu, Shruthi, Fitzgerald, Julie, Saadey, Abbey A, Laster, Brooke, Yan, Pearlly, Webb, Amy, Zhang, Xiaoli, Pietrzak, Maciej, Kokiko-Cochran, Olga N, Ghoneim, Hazem E, Amer, Amal O

“…Alzheimer's disease (AD) is the sixth leading cause of death in the USA. It is established that neuroinflammation contributes to the synaptic loss, neuronal…”
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Divergent Spatial Learning, Enhanced Neuronal Transcription, and Blood–Brain Barrier Disruption Develop During Recovery from Post-Injury Sleep Fragmentation by Tapp, Zoe M., Ren, Cindy, Palmer, Kelsey, Kumar, Julia, Atluri, Ravitej R., Fitzgerald, Julie, Velasquez, John, Godbout, Jonathan, Sheridan, John, Kokiko-Cochran, Olga N.

“…Traumatic brain injury (TBI) causes pathophysiology that may significantly decrease quality of life over time. A major propagator of this response is chronic,…”
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Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy by Bemiller, Shane M, Maphis, Nicole M, Formica, Shane V, Wilson, Gina N, Miller, Crystal M, Xu, Guixiang, Kokiko-Cochran, Olga N, Kim, Ki-Wook, Jung, Steffen, Cannon, Judy L, Crish, Samuel D, Cardona, Astrid E, Lamb, Bruce T, Bhaskar, Kiran

“…Background Fractalkine (CX.sub.3CL1) and its receptor (CX.sub.3CR1) play an important role in regulating microglial function. We have previously shown that…”
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Sleep fragmentation after traumatic brain injury impairs behavior and conveys long-lasting impacts on neuroinflammation by Houle, Samuel, Tapp, Zoe, Dobres, Shannon, Ahsan, Sakeef, Reyes, Yvanna, Cotter, Christopher, Mitsch, Jessica, Zimomra, Zachary, Peng, Juan, Rowe, Rachel K., Lifshitz, Jonathan, Sheridan, John, Godbout, Jonathan, Kokiko-Cochran, Olga N.

“…Traumatic brain injury (TBI) causes a prolonged inflammatory response in the central nervous system (CNS) driven by microglia. Microglial reactivity is…”
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In vivo Mouse Intervertebral Disc Degeneration Models and Their Utility as Translational Models of Clinical Discogenic Back Pain: A Comparative Review by Tang, Shirley N., Walter, Benjamin A., Heimann, Mary K., Gantt, Connor C., Khan, Safdar N., Kokiko-Cochran, Olga N., Askwith, Candice C., Purmessur, Devina

“…Low back pain is a leading cause of disability worldwide and studies have demonstrated intervertebral disc (IVD) degeneration as a major risk factor. While…”
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Multiparity Differentially Affects Specific Aspects of the Acute Neuroinflammatory Response to Traumatic Brain Injury in Female Mice by Gilfarb, Rachel, Tapp, Zoe, Lemanski, Elise, Velasquez, John, Cornelius, Sydney, Kokiko-Cochran, Olga N., Leuner, Benedetta

“…•Parity did not differentially affect gliosis following traumatic brain injury (TBI).•Multiparous mice had diminished numbers of infiltrating leukocytes…”
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