Search Results - "Kokaia, Mérab"

Seizure-induced neurogenesis in the adult brain by Kokaia, Merab

“…It is well established that seizures increase adult neurogenesis in the subventricular and subgranular zones, the most neurogenic regions of the adult rodent…”
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Optogenetics for controlling seizure circuits for translational approaches by Ledri, Marco, Andersson, My, Wickham, Jenny, Kokaia, Merab

“…The advent of optogenetic tools has had a profound impact on modern neuroscience research, revolutionizing our understanding of the brain. These tools offer a…”
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Dynamic interaction of local and transhemispheric networks is necessary for progressive intensification of hippocampal seizures by Berglind, Fredrik, Andersson, My, Kokaia, Merab

“…The detailed mechanisms of progressive intensification of seizures often occurring in epilepsy are not well understood. Animal models of kindling, with…”
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Advances in the development of biomarkers for epilepsy by Pitkänen, Asla, Prof, Löscher, Wolfgang, Prof, Vezzani, Annamaria, Prof, Becker, Albert J, Prof, Simonato, Michele, Prof, Lukasiuk, Katarzyna, Prof, Gröhn, Olli, Prof, Bankstahl, Jens P, PhD, Friedman, Alon, Prof, Aronica, Eleonora, Prof, Gorter, Jan A, Prof, Ravizza, Teresa, PhD, Sisodiya, Sanjay M, Prof, Kokaia, Merab, Prof, Beck, Heinz, Prof

“…Summary Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy remains unsatisfactorily controlled despite the availability of…”
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Human stem cell-derived GABAergic neurons functionally integrate into human neuronal networks by Gonzalez-Ramos, Ana, Waloschková, Eliška, Mikroulis, Apostolos, Kokaia, Zaal, Bengzon, Johan, Ledri, Marco, Andersson, My, Kokaia, Merab

“…Gamma-aminobutyric acid (GABA)-releasing interneurons modulate neuronal network activity in the brain by inhibiting other neurons. The alteration or absence of…”
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Novel approaches to epilepsy treatment by Sørensen, Andreas T., Kokaia, Merab

“…Summary The aim of epilepsy treatment is to achieve complete seizure freedom. Nonetheless, numerous side effects and seizure resistance to antiepileptic drugs…”
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Human Stem Cell-Derived GABAergic Interneurons Establish Efferent Synapses onto Host Neurons in Rat Epileptic Hippocampus and Inhibit Spontaneous Recurrent Seizures by Waloschková, Eliška, Gonzalez-Ramos, Ana, Mikroulis, Apostolos, Kudláček, Jan, Andersson, My, Ledri, Marco, Kokaia, Merab

“…Epilepsy is a complex disorder affecting the central nervous system and is characterised by spontaneously recurring seizures (SRSs). Epileptic patients undergo…”
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Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats by Kandashvili, Manana, Gamkrelidze, Georgi, Tsverava, Lia, Lordkipanidze, Tamar, Lepsveridze, Eka, Lagani, Vincenzo, Burjanadze, Maia, Dashniani, Manana, Kokaia, Merab, Solomonia, Revaz

“…Epilepsy is a severe neurological disease characterized by spontaneous recurrent seizures (SRS). A complex pathophysiological process referred to as…”
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Translational approach for gene therapy in epilepsy: Model system and unilateral overexpression of neuropeptide Y and Y2 receptors by Nikitidou Ledri, Litsa, Melin, Esbjörn, Christiansen, Søren H, Gøtzsche, Casper R, Cifra, Alessandra, Woldbye, David P.D, Kokaia, Mérab

“…Abstract Although novel treatment strategies based on the gene therapy approach for epilepsy has been encouraging, there is still a gap in demonstrating a…”
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Optogenetic control of epileptiform activity by Tønnesen, Jan, Sørensen, Andreas T, Deisseroth, Karl, Lundberg, Cecilia, Kokaia, Merab

“…The optogenetic approach to gain control over neuronal excitability both in vitro and in vivo has emerged as a fascinating scientific tool to explore neuronal…”
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Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients by Wickham, Jenny, Ledri, Marco, Bengzon, Johan, Jespersen, Bo, Pinborg, Lars H., Englund, Elisabet, Woldbye, David P. D., Andersson, My, Kokaia, Merab

“…In epilepsy patients, drug-resistant seizures often originate in one of the temporal lobes. In selected cases, when certain requirements are met, this area is…”
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Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning by Mohapel, Paul, Leanza, Giampiero, Kokaia, Merab, Lindvall, Olle

“…Hippocampus-mediated learning enhances neurogenesis in the adult dentate gyrus (DG), and this process has been suggested to be involved in memory formation…”
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Environment Matters: Synaptic Properties of Neurons Born in the Epileptic Adult Brain Develop to Reduce Excitability by Jakubs, Katherine, Nanobashvili, Avtandil, Bonde, Sara, Ekdahl, Christine T., Kokaia, Zaal, Kokaia, Merab, Lindvall, Olle

“…Neural progenitors in the adult dentate gyrus continuously produce new functional granule cells. Here we used whole-cell patch-clamp recordings to explore…”
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GDNF Increases Inhibitory Synaptic Drive on Principal Neurons in the Hippocampus via Activation of the Ret Pathway by Mikroulis, Apostolos, Waloschková, Eliška, Bengzon, Johan, Woldbye, David, Pinborg, Lars H., Jespersen, Bo, Avila, Anna Sanchez, Laszlo, Zsofia I., Henstridge, Christopher, Ledri, Marco, Kokaia, Merab

“…Glial cell line-derived neurotrophic factor (GDNF) has been shown to counteract seizures when overexpressed or delivered into the brain in various animal…”
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Optogenetics Reveal Delayed Afferent Synaptogenesis on Grafted Human‐Induced Pluripotent Stem Cell‐Derived Neural Progenitors by Avaliani, Natalia, Sørensen, Andreas Toft, Ledri, Marco, Bengzon, Johan, Koch, Philipp, Brüstle, Oliver, Deisseroth, Karl, Andersson, My, Kokaia, Merab

“…Reprogramming of somatic cells into pluripotency stem cell state has opened new opportunities in cell replacement therapy and disease modeling in a number of…”
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Inflammation Regulates Functional Integration of Neurons Born in Adult Brain by Jakubs, Katherine, Bonde, Sara, Iosif, Robert E, Ekdahl, Christine T, Kokaia, Zaal, Kokaia, Merab, Lindvall, Olle

“…Inflammation influences several steps of adult neurogenesis, but whether it regulates the functional integration of the new neurons is unknown. Here, we…”
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VEGF receptor-2 (Flk-1) overexpression in mice counteracts focal epileptic seizures by Nikitidou, Litsa, Kanter-Schlifke, Irene, Dhondt, Joke, Carmeliet, Peter, Lambrechts, Diether, Kokaia, Mérab

“…Vascular endothelial growth factor (VEGF) was first described as an angiogenic agent, but has recently also been shown to exert various neurotrophic and…”
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Optogenetic inhibition of chemically induced hypersynchronized bursting in mice by Berglind, Fredrik, Ledri, Marco, Sørensen, Andreas Toft, Nikitidou, Litsa, Melis, Miriam, Bielefeld, Pascal, Kirik, Deniz, Deisseroth, Karl, Andersson, My, Kokaia, Merab

“…Abstract Synchronized activity is common during various physiological operations but can culminate in seizures and consequently in epilepsy in pathological…”
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Gene Therapy Vector Encoding Neuropeptide Y and Its Receptor Y2 for Future Treatment of Epilepsy: Preclinical Data in Rats by Szczygieł, Julia Alicja, Danielsen, Kira Iben, Melin, Esbjörn, Rosenkranz, Søren Hofman, Pankratova, Stanislava, Ericsson, Annika, Agerman, Karin, Kokaia, Merab, Woldbye, David Paul Drucker

“…Gene therapy to treat pharmacoresistant temporal lobe epilepsy in humans is now being developed using an AAV vector (CG01) that encodes the combination of…”
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Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice by Parish, Clare L, Castelo-Branco, Gonçalo, Rawal, Nina, Tonnesen, Jan, Sorensen, Andreas Toft, Salto, Carmen, Kokaia, Merab, Lindvall, Olle, Arenas, Ernest

“…Dopamine (DA) cell replacement therapy in Parkinson disease (PD) can be achieved using human fetal mesencephalic tissue; however, limited tissue availability…”
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