Search Results - "Koka, Saisudha"

High Mobility Group Box 1 Mediates TMAO-Induced Endothelial Dysfunction by Singh, Gurinder Bir, Zhang, Yang, Boini, Krishna M, Koka, Saisudha

“…The intestinal microbe-derived metabolite trimethylamine N-oxide (TMAO) is implicated in the pathogenesis of cardiovascular diseases (CVDs). The molecular…”
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Chronic inhibition of phosphodiesterase 5 with tadalafil affords cardioprotection in a mouse model of metabolic syndrome: role of nitric oxide by Koka, Saisudha, Xi, Lei, Kukreja, Rakesh C.

“…Patients with metabolic syndrome (MetS) often exhibit generalized endothelial and cardiac dysfunction with decreased nitric oxide (NO) production and/or…”
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Role of Gut Microbial Metabolites in Cardiovascular Diseases-Current Insights and the Road Ahead by Datta, Sayantap, Pasham, Sindhura, Inavolu, Sriram, Boini, Krishna M, Koka, Saisudha

“…Cardiovascular diseases (CVDs) are the leading cause of premature morbidity and mortality globally. The identification of novel risk factors contributing to…”
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Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia by Koka, Saisudha, Xia, Min, Chen, Yang, Bhat, Owais M., Yuan, Xinxu, Boini, Krishna M., Li, Pin-Lan

“…The NLRP3 inflammasome has been reported to be activated by atherogenic factors, whereby endothelial injury and consequent atherosclerotic lesions are…”
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Simvastatin improves lysosome function via enhancing lysosome biogenesis in endothelial cells by Zhang, Youzhi, Wang, Yun-Ting, Koka, Saisudha, Zhang, Yang, Hussain, Tahir, Li, Xiang

“…Nlrp3 inflammasomes were shown to play a critical role in triggering obesity-associated early onsets of cardiovascular complications such as endothelial…”
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TACE inhibition: a promising therapeutic intervention against AATF‐mediated steatohepatitis to hepatocarcinogenesis by Srinivas, Akshatha N., Suresh, Diwakar, Vishwanath, Prashant M., Satish, Suchitha, Santhekadur, Prasanna K., Koka, Saisudha, Kumar, Divya P.

“…Metabolic dysfunction‐associated steatohepatitis‐driven hepatocellular carcinoma (MASH‐HCC) is a global clinical challenge for which there is a limited…”
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Inflammatory Mediators in Obesity by Kumar, Divya P., Koka, Saisudha, Li, Chao, Rajagopal, Senthilkumar

“…[...]obesity, the accumulation of excessive fat, adversely affects nearly all the physiological functions of the body and has emerged as a serious public…”
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Podocyte NLRP3 Inflammasome Activation and Formation by Adipokine Visfatin by Koka, Saisudha, Xia, Min, Zhang, Chun, Zhang, Yang, Li, Pin-Lan, Boini, Krishna M

“…NLRP3 inflammasome activation has been reported to be an early mechanism responsible for glomerular inflammation and injury in obese mice. However, the precise…”
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Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide by Gulbins, Erich, Lang, Florian, Lang, Philipp A, Schenck, Marcus, Nicolay, Jan P, Becker, Jan Ulrich, Kempe, Daniela S, Lupescu, Adrian, Koka, Saisudha, Eisele, Kerstin, Klarl, Barbara A, Rübben, Herbert, Schmid, Kurt W, Mann, Klaus, Hildenbrand, Sibylle, Hefter, Harald, Huber, Stephan M, Wieder, Thomas, Erhardt, Andreas, Häussinger, Dieter

“…Wilson disease is caused by accumulation of Cu(2+) in cells, which results in liver cirrhosis and, occasionally, anemia. Here, we show that Cu(2+) triggers…”
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Suicide for Survival - Death of Infected Erythrocytes as a Host Mechanism to Survive Malaria by Föller, Michael, Bobbala, Diwakar, Koka, Saisudha, Huber, Stephan M., Gulbins, Erich, Lang, Florian

“…The pathogen of malaria, Plasmodium, enters erythrocytes and thus escapes recognition by the immune system. The pathogen induces oxidative stress to the host…”
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Anemia and splenomegaly in cGKI-deficient mice by Föller, Michael, Feil, Susanne, Ghoreschi, Kamran, Koka, Saisudha, Gerling, Andrea, Thunemann, Martin, Hofmann, Franz, Schuler, Beat, Vogel, Johannes, Pichler, Bernd, Kasinathan, Ravi S, Nicolay, Jan P, Huber, Stephan M, Lang, Florian, Feil, Robert

“…To explore the functional significance of cGMP-dependent protein kinase type I (cGKI) in the regulation of erythrocyte survival, gene-targeted mice lacking…”
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A simple and sensitive HPLC fluorescence method for determination of tadalafil in mouse plasma by Farthing, Christine A., Farthing, Don E., Koka, Saisudha, Larus, Terri, Fakhry, Itaf, Xi, Lei, Kukreja, Rakesh C., Sica, Domenic, Gehr, Todd W.B.

“…A simple and sensitive high-performance liquid chromatographic (HPLC) method utilizing fluorescence detection was developed for the determination of the…”
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Non-Selective Cation Channel-Mediated Ca2+-Entry and Activation of Ca2+/Calmodulin-Dependent Kinase II Contribute to G2/M Cell Cycle Arrest and Survival of Irradiated Leukemia Cells by Heise, Nicole, Palme, Daniela, Misovic, Milan, Koka, Saisudha, Rudner, Justine, Lang, Florian, Salih, Helmut R., Huber, Stephan M., Henke, Guido

“…Genotoxic stress induces cell cycle arrest and DNA repair which may enable tumor cells to survive radiation therapy. Here, we defined the role of Ca 2+…”
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Characterization and Activation of NLRP3 Inflammasomes in the Renal Medulla in Mice by Xia, Min, Abais, Justine M., Koka, Saisudha, Meng, Nan, Gehr, Todd W., Boini, Krishna M., Li, Pin-Lan

“…Abstract Background/Aims: Recent studies have indicated that local inflammatory mediators are importantly involved in the regulation of renal function…”
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Enhanced insulin sensitivity of gene-targeted mice lacking functional KCNQ1 by Boini, Krishna M, Graf, Dirk, Hennige, Anita M, Koka, Saisudha, Kempe, Daniela S, Wang, Kan, Ackermann, Teresa F, Föller, Michael, Vallon, Volker, Pfeifer, Karl, Schleicher, Erwin, Ullrich, Susanne, Häring, Hans-Ulrich, Häussinger, Dieter, Lang, Florian

“…The pore-forming K+-channel alpha-subunit KCNQ1 is expressed in a wide variety of tissues including heart, skeletal muscle, liver, and epithelia. Most recent…”
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Accelerated suicidal erythrocyte death in Klotho-deficient mice by Kempe, Daniela S., Ackermann, Teresa F., Fischer, Stephanie S., Koka, Saisudha, Boini, Krishna M., Mahmud, Hasan, Föller, Michael, Rosenblatt, Kevin P., Kuro-o, Makoto, Lang, Florian

“…Klotho, a membrane protein mainly expressed in parathyroid glands, kidney, and choroid plexus, counteracts aging and increases the life span. Accordingly, life…”
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Identification of proteomic alterations in TMAO‐Induced Cardiac Injury by Boini, Krishna, Koka, Saisudha

“…Gut microbial metabolite, trimethylamine N‐oxide (TMAO), increases the risk of cardiovascular diseases. The present study was designed to determine the effects…”
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Enhanced susceptibility to suicidal death of erythrocytes from transgenic mice overexpressing erythropoietin by Föller, Michael, Kasinathan, Ravi S, Koka, Saisudha, Huber, Stephan M, Schuler, Beat, Vogel, Johannes, Gassmann, Max, Lang, Florian

“…Eryptosis, a suicidal death of mature erythrocytes, is characterized by decrease of cell volume, cell membrane blebbing, and breakdown of cell membrane…”
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Azathioprine favourably influences the course of malaria by Bobbala, Diwakar, Koka, Saisudha, Geiger, Corinna, Föller, Michael, Huber, Stephan M, Lang, Florian

“…Azathioprine triggers suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and exposure of phosphatidylserine at the erythrocyte surface…”
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SKQ1 Improves Trimethylamine-N-Oxide-Induced Endothelial Dysfunction by Attenuating Oxidative Stress and Restoring Junctional Proteins by Koka, Saisudha, Powers, Zachary, Boini, Krishna

“…Abstract only In recent years, the role of microbiota and microbial metabolites in the progress of aging and age-related diseases has been attracting increased…”
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