Search Results - "Kok-Pian Ang"

10H-3,6-Diazaphenothiazine induces G2/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NF-κB and (BIRC6-XIAP) complexes by Zhang, Jianxin, Chen, Ming, Zhang, Wenzhi, Patrick Nwabueze Okechukwu, Morak-Młodawska, Beata, Pluta, Krystian, Jeleń, Malgorzata, Abdah Md Akim, Kok-Pian Ang, Kah Kooi Ooi

“…The asymptomatic properties and high treatment resistance of ovarian cancer result in poor treatment outcomes and high mortality rates. Although the…”
Get full text

Cytotoxicity of bismuth(III) dithiocarbamate derivatives by promoting a mitochondrial-dependent apoptotic pathway and suppressing MCF-7 breast adenocarcinoma cell invasion by Chan, Pit Foong, Ang, Kok Pian, Hamid, Roslida Abd

“…We previously reported that the bismuth(III) dithiocarbamate derivative, bismuth diethyldithiocarbamate ( 1 ) exhibited greater cytotoxicity while inducing…”
Get full text

A bismuth diethyldithiocarbamate compound induced apoptosis via mitochondria-dependent pathway and suppressed invasion in MCF-7 breast cancer cells by Chan, Pit Foong, Ang, Kok Pian, Hamid, Roslida Abd

“…Interest in bismuth(III) dithiocarbamate complexes as potential drug candidates is increasing due to their low toxicity compared to other group 15 elements…”
Get full text

Antiproliferative activity exerted by tricyclohexylphosphanegold(I) n-mercaptobenzoate against MCF-7 and A2780 cell lines: the role of p53 signaling pathways by Ang, Kok Pian, Chan, Pit Foong, Hamid, Roslida Abd

“…Based on the recent studies depicting the potential of heterometallic gold complexes as potent antiproliferative agents, herein we first reported the…”
Get full text

Induction of apoptosis on ovarian adenocarcinoma cells, A2780 by tricyclohexylphosphanegold (I) mercaptobenzoate derivatives via intrinsic and extrinsic pathways by Ang, Kok Pian, Chan, Pit Foong, Hamid, Roslida Abd

“…Tricyclohexylphosphanegold(I) n -mercaptobenzoate ( n  = 2, 3, 4) labelled as 1 – 3 were previously reported to significantly suppress thioredoxin reductase…”
Get full text

10H‐3,6‐Diazaphenothiazines triggered the mitochondrial‐dependent and cell death receptor‐dependent apoptosis pathways and further increased the chemosensitivity of MCF‐7 breast cancer cells via inhibition of AKT1 pathways by Ren, Guanghui, Hao, Xiaoyan, Yang, Shuyi, Chen, Jun, Qiu, Guobin, Ang, Kok Pian, Mohd Tamrin, Mohd Islahuddin

“…Breast cancer is one of the leading causes of death in cancer categories, followed by lung, colorectal, and ovarian among the female gender across the world…”
Get full text

P3J20-9 Anti-inflammatory activity and vascular permeability reduction by aqueous extract of Bixa orellana leaves by Yoke Keong Yong, Roslida A. Hamid, Muhammad Nazrul Hakim Abdullah, Kok Pian Ang, Zuraini Ahmad

Get full text

Phosphanegold(I) dithiocarbamates, R3PAu[SC(S)N(iPr)CH2CH2OH] for R = Ph, Cy and Et: Role of phosphane-bound R substituents upon in vitro cytotoxicity against MCF-7R breast cancer cells and cell death pathways by Jamaludin, Nazzatush Shimar, Goh, Zheng-Jie, Cheah, Yoke Kqueen, Ang, Kok-Pian, Sim, Jiun Horng, Khoo, Chai Hoon, Fairuz, Zainal Abidin, Halim, Siti Nadiah Binti Abdul, Ng, Seik Weng, Seng, Hoi-Ling, Tiekink, Edward R.T.

“…The synthesis and characterisation of R3PAu[S2CN(iPr)CH2CH2OH], for R = Ph (1), Cy (2) and Et (3)4, is reported. Compounds 1–3 are cytotoxic against the…”
Get full text

A bismuth diethyldithiocarbamate compound promotes apoptosis in HepG2 carcinoma, cell cycle arrest and inhibits cell invasion through modulation of the NF-κB activation pathway by Ishak, Dayang Hazwani Abang, Ooi, Kah Kooi, Ang, Kok-Pian, Akim, Abdah Md, Cheah, Yoke-Kqueen, Nordin, Norshariza, Halim, Siti Nadiah Binti Abdul, Seng, Hoi-Ling, Tiekink, Edward R.T.

“…The compound with R=CH2CH3 in Bi(S2CNR2)3 (1) is highly cytotoxic against a range of human carcinoma, whereas that with R=CH2CH2OH (2) is considerably less so…”
Get full text

Phosphanegold(I) thiolates, Ph3PAu[SC(OR)=NC6H4Me-4] for R = Me, Et and iPr, induce apoptosis, cell cycle arrest and inhibit cell invasion of HT-29 colon cancer cells through modulation of the nuclear factor-κB activation pathway and ubiquitination by Ooi, Kah Kooi, Yeo, Chien Ing, Ang, Kok-Pian, Akim, Abdah Md, Cheah, Yoke-Kqueen, Halim, Siti Nadiah Abdul, Seng, Hoi-Ling, Tiekink, Edward R. T.

“…The phosphanegold(I) carbonimidothioates, Ph 3 PAu{SC(OR)=NC 6 H 4 Me-4} for R = Me ( 1 ), Et ( 2 ) and iPr ( 3 ), feature linear P–Au–S coordination…”
Get full text

Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro by Ahmad, Zuraini, Ng, Chin Theng, Fong, Lai Yen, Bakar, Nurul Ain Abu, Hussain, Nor Hayuti Mohd, Ang, Kok Pian, Ee, Gwendoline Cheng Lian, Hakim, Muhammad Nazrul

“…Endothelial dysfunction has been implicated in the pathogenesis of atherosclerosis. Salvia miltiorrhiza (danshen) is a traditional Chinese medicine that has…”
Get full text

Pathogenic Gram-positive bacteria are highly sensitive to triphenylphosphanegold(O-alkylthiocarbamates), Ph3PAu[SC(OR)=N(p-tolyl)] (R = Me, Et and iPr) by Yeo, Chien Ing, Sim, Jiun-Horng, Khoo, Chai-Hoon, Goh, Zheng-Jie, Ang, Kok-Pian, Cheah, Yoke-Kqueen, Fairuz, Zainal Abidin, Halim, Siti Nadiah Binti Abdul, Ng, Seik Weng, Seng, Hoi-Ling, Tiekink, Edward R. T.

“…The phosphanegold(I) thiocarbamides, Ph 3 PAu{SC(OR)=NC 6 H 4 Me-4} for R = Me ( 1 ), Et ( 2 ) and iPr ( 3 ), have been shown to have essentially linear gold…”
Get full text

Cryptotanshinone attenuates in vitro oxLDL-induced pre-lesional atherosclerotic events by Ang, Kok-Pian, Tan, Heng-Kean, Selvaraja, Malarvilli, Kadir, Arifah A, Somchit, Muhammad N, Akim, Abdah M, Zakaria, Zainul A, Ahmad, Zuraini

“…Development of early stage atherosclerosis involves the activation of endothelial cells by oxidized low-density lipoprotein (oxLDL) with subsequent increases…”
Get more information

S-phase arrest and apoptosis in human breast adenocarcinoma MCF-7 cells via mitochondrial dependent pathway induced by tricyclohexylphosphine gold (I) n-mercaptobenzoate complexes by Pian, Ang Kok, Foong, Chan Pit, Hamid, Roslida Abd

“…We have previously reported the inhibition of thioredoxin reductase (TrxR) and invasion by tricyclohexylphosphine gold (I) n-mercaptobenzoate (n = 2, 3, 4)…”
Get full text

Molecular mechanisms of apoptosis and cell selectivity of zinc dithiocarbamates functionalized with hydroxyethyl substituents by Tan, Yee Seng, Ooi, Kah Kooi, Ang, Kok Pian, Akim, Abdah Md, Cheah, Yoke-Kqueen, Halim, Siti Nadiah Abdul, Seng, Hoi-Ling, Tiekink, Edward R.T.

“…In the solid state each of three binuclear zinc dithiocarbamates bearing hydroxyethyl groups, {Zn[S2CN(R)CH2CH2OH]2}2 for R=iPr (1), CH2CH2OH (2), and Me (3),…”
Get full text

10 H ‐3,6‐Diazaphenothiazines triggered the mitochondrial‐dependent and cell death receptor‐dependent apoptosis pathways and further increased the chemosensitivity of MCF‐7 breast cancer cells via inhibition of AKT1 pathways by Ren, Guanghui, Hao, Xiaoyan, Yang, Shuyi, Chen, Jun, Qiu, Guobin, Ang, Kok Pian, Mohd Tamrin, Mohd Islahuddin

“…Breast cancer is one of the leading causes of death in cancer categories, followed by lung, colorectal, and ovarian among the female gender across the world…”
Get full text

Metabolic utilization of human osteoblast cell line hFOB 1.19 under normoxic and hypoxic conditions: A phenotypic microarray analysis by Cui, Yan Chao, Qiu, Yu Sheng, Wu, Qiong, Bu, Gang, Peli, Amira, Teh, Seoh Wei, Ang, Kok Pian, Joseph, Narcisse MS, Koh, Avin Ee-Hwan, Farhana, Aisha, Alzahrani, Badr, Khan, Mohammed Safwan Ali, Samrot, Antony V, Mok, Pooi Ling, Subbiah, Suresh Kumar

“…Osteoblasts play an important role in bone regeneration and repair. The hypoxia condition in bone occurs when bone undergoes fracture, and this will trigger a…”
Get full text

G2/M cell cycle arrest on HT-29 cancer cells and toxicity assessment of triphenylphosphanegold(I) carbonimidothioates, Ph3PAu[SC(OR)=NPh], R=Me, Et, and iPr, during zebrafish development by Ooi, Kah Kooi, Yeo, Chien Ing, Mahandaran, Theventhiran, Ang, Kok Pian, Akim, Abdah Md, Cheah, Yoke-Kqueen, Seng, Hoi-Ling, Tiekink, Edward R.T.

“…Phosphanegold(I) thiolates, Ph3PAu[SC(OR)=NPh], R=Me (1), Et (2) and iPr (3), were previously shown to be significantly cytotoxic toward HT-29 cancer cells and…”
Get full text

Zinc (II) complex with a cationic Schiff base ligand: Synthesis, characterization, and biological studies by Lee, Sze Koon, Tan, Kong Wai, Ng, Seik Weng, Ooi, Kah Kooi, Ang, Kok Pian, Abdah, Md Akim

“…A cationic Schiff base ligand, TSB (L) and its Zn (II) complex (1) have been synthesized and characterized. Their interactions with topoisomerase I,…”
Get full text

G 2 /M cell cycle arrest on HT-29 cancer cells and toxicity assessment of triphenylphosphanegold(I) carbonimidothioates, Ph 3 PAu[SC(OR)=NPh], R=Me, Et, and iPr, during zebrafish development by Ooi, Kah Kooi, Yeo, Chien Ing, Mahandaran, Theventhiran, Ang, Kok Pian, Akim, Abdah Md, Cheah, Yoke-Kqueen, Seng, Hoi-Ling, Tiekink, Edward R T

“…Phosphanegold(I) thiolates, Ph PAu[SC(OR)=NPh], R=Me (1), Et (2) and iPr (3), were previously shown to be significantly cytotoxic toward HT-29 cancer cells and…”
Get full text