Search Results - "Kok, RJ"

Glomerular and tubular induction of the transcription factor c-Jun in human renal disease by De Borst, MH, Prakash, J, Melenhorst, WBWH, van den Heuvel, MC, Kok, RJ, Navis, G, van Goor, H

“…The transcription factor c-Jun regulates the expression of genes involved in proliferation and inflammation in many cell types but its role in human renal…”
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RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature by Temming, Kai, Schiffelers, Raymond M., Molema, Grietje, Kok, Robbert J.

“…During the past decade, RGD-peptides have become a popular tool for the targeting of drugs and imaging agents to α vβ 3-integrin expressing tumour vasculature…”
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Docosahexaenoic acid liposomes for targeting chronic inflammatory diseases and cancer: an in vitro assessment by Alaarg, Amr, Jordan, Nan Yeun, Verhoef, Johan Jf, Metselaar, Josbert M, Storm, Gert, Kok, Robbert J

“…Inflammation, oxidative stress, and uncontrolled cell proliferation are common key features of chronic inflammatory diseases, such as atherosclerosis and…”
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The influence of forward-scattered light in transmission measurements of (exo)planetary atmospheres by de Kok, R.J., Stam, D.M.

“…► We simulate atmospheric transmission measurements with a Monte Carlo model. ► Forward-scattered light can change exoplanet transit depths significantly. ►…”
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Covalently Linked Au Nanoparticles to a Viral Vector:  Potential for Combined Photothermal and Gene Cancer Therapy by Everts, Maaike, Saini, Vaibhav, Leddon, Jennifer L, Kok, Robbert J, Stoff-Khalili, Mariam, Preuss, Meredith A, Millican, C. Leigh, Perkins, Guy, Brown, Joshua M, Bagaria, Hitesh, Nikles, David E, Johnson, Duane T, Zharov, Vladimir P, Curiel, David T

“…Hyperthermia can be produced by near-infrared laser irradiation of gold nanoparticles present in tumors and thus induce tumor cell killing via a bystander…”
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Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin by Schiffelers, Raymond M, Koning, Gerben A, ten Hagen, Timo L.M, Fens, Marcel H.A.M, Schraa, Astrid J, Janssen, Adriënne P.C.A, Kok, Robbert J, Molema, Grietje, Storm, Gert

“…Angiogenesis is a key process in the growth and metastasis of a tumor. Disrupting this process is considered a promising treatment strategy. Therefore, a drug…”
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A novel strategy to modify adenovirus tropism and enhance transgene delivery to activated vascular endothelial cells in vitro and in vivo by Ogawara, Ken-ichi, Rots, Marianne G, Kok, Robbert J, Moorlag, Henk E, Van Loenen, Anne-Miek, Meijer, Dirk K F, Haisma, Hidde J, Molema, Grietje

“…To assess the possibilities of retargeting adenovirus to activated endothelial cells, we conjugated bifunctional polyethylene glycol (PEG) onto the adenoviral…”
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Preparation and functional evaluation of RGD-modified proteins as alpha(v)beta(3) integrin directed therapeutics by Kok, Robbert J, Schraa, Astrid J, Bos, Erwin J, Moorlag, Henk E, Asgeirsdóttir, Sigridur A, Everts, Maaike, Meijer, Dirk K F, Molema, Grietje

“…Tumor blood vessels can be selectively targeted by RGD-peptides that bind to alpha(v)beta(3) integrin on angiogenic endothelial cells. By inhibiting the…”
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Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells by Dolman, M E M, Harmsen, Stefan, Pieters, Ebel H E, Sparidans, Rolf W, Lacombe, Marie, Szokol, Bálint, Orfi, László, Kéri, György, Storm, Gert, Hennink, Wim E, Kok, Robbert J

“…Activated proximal tubular cells play an important role in renal fibrosis. We investigated whether sunitinib and a kidney-targeted conjugate of sunitinib were…”
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In vitro cellular handling and in vivo targeting of E-selectin-directed immunoconjugates and immunoliposomes used for drug delivery to inflamed endothelium by EVERTS, Maaike, KONING, Gerben A, KOK, Robbert J, ASGEIRSDOTTIR, Sigridur A, VESTWEBER, Dietmar, MEIJER, Dirk K. F, STORM, Gert, MOLEMA, Grietje

“…Drug targeting to activated endothelial cells is now being explored as a new approach to interfere with chronic inflammation. This study compares a…”
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Studies on the targeted delivery of the antifibrogenic compound mycophenolic acid to the hepatic stellate cell by Greupink, Rick, Bakker, Hester I., Reker-Smit, Catharina, van Loenen-Weemaes, Anne-miek, Kok, Robbert-Jan, Meijer, Dirk K.F., Beljaars, Leonie, Poelstra, Klaas

“…Hepatic stellate cell (HSC) activation and proliferation are key events in the pathology of liver fibrosis. Inhibiting these parameters, therefore, is a…”
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Design, synthesis, and biological evaluation of a dual tumor-specific motive containing integrin-targeted plasmin-cleavable doxorubicin prodrug by de Groot, Franciscus M H, Broxterman, Henk J, Adams, Hans P H M, van Vliet, Alexandra, Tesser, Godefridus I, Elderkamp, Yvonne W, Schraa, Astrid J, Kok, Robert Jan, Molema, Grietje, Pinedo, Herbert M, Scheeren, Hans W

“…The design, synthesis, and initial biological evaluation of a doxorubicin prodrug that contains a dual tumor specific moiety, which allows enhanced tumor…”
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Peptide-targeted PEG-liposomes in anti-angiogenic therapy by Janssen, A.P.C.A, Schiffelers, R.M, ten Hagen, T.L.M, Koning, G.A, Schraa, A.J, Kok, R.J, Storm, G, Molema, G

“…Peptides with the RGD amino acid sequence show affinity for the alpha(v)beta(3) integrin, an integrin which is over-expressed on angiogenic endothelium and…”
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Targeting of RGD‐modified proteins to tumor vasculature: A pharmacokinetic and cellular distribution study by Schraa, Astrid J., Kok, Robbert J., Moorlag, Henk E., Bos, Erwin J., Proost, Johannes H., Meijer, Dirk K.F., de Leij, Lou F.M.H., Molema, Grietje

“…Angiogenesis‐associated integrin αvβ3 represents an attractive target for therapeutic intervention because it becomes highly upregulated on angiogenic…”
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Selective Intracellular Delivery of Dexamethasone into Activated Endothelial Cells Using an E-Selectin-Directed Immunoconjugate by Everts, Maaike, Kok, Robbert J, Asgeirsdottir, Sigridur A, Melgert, Barbro N, Moolenaar, Tom J. M, Koning, Gerben A, van Luyn, Marja J. A, Meijer, Dirk K. F, Molema, Grietje

“…In chronic inflammatory diseases, the endothelium is an attractive target for pharmacological intervention because it plays an important role in leukocyte…”
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Endothelial cells internalize and degrade RGD-modified proteins developed for tumor vasculature targeting by Schraa, Astrid J, Kok, Robbert J, Berendsen, Agnes D, Moorlag, Henk E, Bos, Erwin J, Meijer, Dirk K.F, de Leij, Lou F.M.H, Molema, Grietje

“…Tumor vasculature can be targeted by peptides containing an RGD (Arg–Gly–Asp) sequence, which bind to α vβ 3 and α vβ 5 integrins on angiogenic endothelial…”
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RENAL-SELECTIVE DELIVERY AND ANGIOTENSIN-CONVERTING ENZYME INHIBITION BY SUBCUTANEOUSLY ADMINISTERED CAPTOPRIL-LYSOZYME by PRAKASH, Jai, VAN LOENEN-WEEMAES, Annemiek M, HAAS, Marijke, PROOST, Johannes H, MEIJER, Dirk K. F, MOOLENAAR, Frits, POELSTRA, Klaas, KOK, Robbert J

“…In previous studies, we have demonstrated that the low molecular weight protein lysozyme can be used as a renal-selective drug carrier for delivery of the…”
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Delivery of pharmacologically active dexamethasone into activated endothelial cells by dexamethasone–anti-E-selectin immunoconjugate by Ásgeirsdóttir, Sigridur A., Kok, Robbert J., Everts, Maaike, Meijer, Dirk K.F., Molema, Grietje

“…To deliver selectively anti-inflammatory agents into activated endothelial cells, drug-targeting conjugates were developed. Dexamethasone (Dexa) was covalently…”
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Cellular handling of a dexamethasone-anti-E-selectin immunoconjugate by activated endothelial cells: Comparison with free dexamethasone by KOK, Robbert J, EVERTS, Maaike, ASGEIRSDOTTIR, Sigridur A, MEIJER, Dirk K. F, MOLEMA, Grietje

“…For selective inhibition of endothelial cell activation in chronic inflammation, we have developed a dexamethasone-anti-E-selectin immunoconjugate. The present…”
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Bioanalysis and pharmacokinetics of the p38 MAPkinase inhibitor SB202190 in rats by Prakash, Jai, Saluja, Vinay, Visser, Jan, Moolenaar, Frits, Meijer, Dirk K.F., Poelstra, Klaas, Kok, Robbert J.

“…We have developed a sensitive and reproducible high performance liquid chromatography (HPLC)-UV method for the quantification of the p38 MAPkinase inhibitor…”
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