Search Results - "Kok, Miranda G.M."

Volumetric absorptive microsampling: Current advances and applications by Kok, Miranda G.M., Fillet, Marianne

“…[Display omitted] •First critical and comprehensive review on volumetric absorptive microsampling.•Practical aspects of VAMS handling are…”
Get full text

Anionic metabolic profiling of urine from antibiotic-treated rats by capillary electrophoresis–mass spectrometry by Kok, Miranda G. M., Ruijken, Marco M. A., Swann, Jonathan R., Wilson, Ian D., Somsen, Govert W., de Jong, Gerhardus J.

“…A recently developed capillary electrophoresis (CE)-negative-ionisation mass spectrometry (MS) method was used to profile anionic metabolites in a…”
Get full text

Beyond dried blood spot: Current microsampling techniques in the context of biomedical applications by Nys, Gwenaël, Kok, Miranda G.M., Servais, Anne-Catherine, Fillet, Marianne

“…Dried blood spot (DBS) has been used for more than 50 years for the screening of inborn errors of metabolism in newborns. Although DBS has remained the…”
Get full text

Targeted metabolomics of whole blood using volumetric absorptive microsampling by Kok, Miranda G.M., Nix, Cindy, Nys, Gwenaël, Fillet, Marianne

“…Volumetric absorptive microsampling (VAMS) enables the collection of small and accurate quantities of biological fluids. Therefore, this sampling technique is…”
Get full text

A Novel and Sensitive Method for the Analysis of Fatty Acid Biosignatures by Capillary Electrophoresis-Mass Spectrometry by Kok, Miranda G. M., Mora, Maria F., Noell, Aaron C., Parker, Ceth W., Willis, Peter A.

“…Fatty acids are a well-established class of compounds targeted as biosignatures for future missions to look for evidence of life on ocean worlds such as Europa…”
Get full text

Bioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion in the framework of the Three Rs rule by Thiry, Justine, Kok, Miranda G.M., Collard, Laurence, Frère, Antoine, Krier, Fabrice, Fillet, Marianne, Evrard, Brigitte

“…Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer…”
Get full text

Sampling only ten microliters of whole blood for the quantification of poorly soluble drugs: Itraconazole as case study by Thiry, Justine, Evrard, Brigitte, Nys, Gwenaël, Fillet, Marianne, Kok, Miranda G.M.

“…•Quantification of itraconazole using only 10μL of whole blood.•The method has been validated and the stability of itraconazole has been assessed.•The…”
Get full text

The role of capillary electrophoresis in metabolic profiling studies employing multiple analytical techniques by Kok, Miranda G.M., Somsen, Govert W., de Jong, Gerhardus J.

“…•Capillary electrophoresis (CE) in metabolomics with multiple analytical techniques.•CE coupled to mass spectrometry compared with other analytical…”
Get full text

Whole blood microsampling for the quantitation of estetrol without derivatization by liquid chromatography-tandem mass spectrometry by Nys, Gwenaël, Gallez, Anne, Kok, Miranda G.M., Cobraiville, Gaël, Servais, Anne-Catherine, Piel, Géraldine, Pequeux, Christel, Fillet, Marianne

“…[Display omitted] •A UHPLC–MS/MS method is proposed for the analysis of estetrol without derivatization.•NH4F as LC additive is used to reach needed…”
Get full text

Comparison of capillary electrophoresis–mass spectrometry and hydrophilic interaction chromatography–mass spectrometry for anionic metabolic profiling of urine by Kok, Miranda G.M., Somsen, Govert W., de Jong, Gerhardus J.

“…In order to assess the utility of a recently developed capillary electrophoresis–mass spectrometry (CE–MS) method for the study of anionic metabolites in…”
Get full text

Capillary electrophoresis-mass spectrometry for targeted and untargeted analysis of the sub-5 kDa urine metabolome of patients with prostate or bladder cancer: A feasibility study by MacLennan, Matthew S., Kok, Miranda G.M., Soliman, Laiel, So, Alan, Hurtado-Coll, Antonio, Chen, David D.Y.

“…Targeted and untargeted analyses of the sub-5 kDa urine metabolome of genitourinary cancer patients (prostate and/or bladder) were performed without chemical…”
Get full text

Comparison of nanofluidic and ultra-high performance liquid chromatography-tandem mass spectrometry for high sensitive pharmacokinetic studies of estrogens starting from whole blood microsampling by Nys, Gwenaël, Cobraiville, Gaël, Kok, Miranda G.M., Wéra, Odile, Servais, Anne-Catherine, Fillet, Marianne

“…•A nanofluidic LC–MS/MS method is developed and compared to a reference UHPLC–MS/MS.•Two estrogens are chosen as model analytes and collected by whole blood…”
Get full text

Sensitivity enhancement in capillary electrophoresis-mass spectrometry of anionic metabolites using a triethylamine-containing background electrolyte and sheath liquid by Kok, Miranda G. M., de Jong, Gerhardus J., Somsen, Govert W.

“…Analyte responses in CE‐ESI‐MS using negative ionization are frequently relatively low, thereby limiting sensitivity in metabolomics applications. In order to…”
Get full text

Hydrophilic interaction chromatography–mass spectrometry for anionic metabolic profiling of urine from antibiotic-treated rats by Kok, Miranda G.M., Swann, Jonathan R., Wilson, Ian D., Somsen, Govert W., de Jong, Gerhardus J.

“…•HILIC–MS in negative ionization mode allows study of microbial–host co-metabolism.•Using PCA, urine samples from rats receiving different antibiotic…”
Get full text