Search Results - "Kojima, Mitsuaki"

Exosomes in postshock mesenteric lymph are key mediators of acute lung injury triggering the macrophage activation via Toll‐like receptor 4 by Kojima, Mitsuaki, Gimenes‐Junior, Joao A., Chan, Theresa W., Eliceiri, Brian P., Baird, Andrew, Costantini, Todd W., Coimbra, Raul

“…Acute lung injury (ALI) is a common cause of morbidity in patients after severe injury due to dysregulated inflammation, which is believed to be driven by…”
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Profiles of lipid, protein and microRNA expression in exosomes derived from intestinal epithelial cells after ischemia-reperfusion injury in a cellular hypoxia model by Senda, Atsushi, Kojima, Mitsuaki, Watanabe, Arisa, Kobayashi, Tetsuyuki, Morishita, Koji, Aiboshi, Junichi, Otomo, Yasuhiro

“…Intestinal ischemia-reperfusion injury leads to proinflammatory responses via gut-derived mediators, and accumulating evidence suggests that exosomes secreted…”
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Open-chest versus closed-chest cardiopulmonary resuscitation in trauma patients with signs of life upon hospital arrival: a retrospective multicenter study by Endo, Akira, Kojima, Mitsuaki, Hong, Zhi-Jie, Otomo, Yasuhiro, Coimbra, Raul

“…Abstract Background The effectiveness and indications of open-chest cardiopulmonary resuscitation (OCCPR) have been still debatable. Although current…”
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Profiles of lipid, protein and microRNA expression in exosomes derived from intestinal epithelial cells after ischemia-reperfusion injury in a cellular hypoxia model by Atsushi Senda, Mitsuaki Kojima, Arisa Watanabe, Tetsuyuki Kobayashi, Koji Morishita, Junichi Aiboshi, Yasuhiro Otomo

“…Intestinal ischemia-reperfusion injury leads to proinflammatory responses via gut-derived mediators, and accumulating evidence suggests that exosomes secreted…”
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Gut epithelial cell-derived exosomes trigger posttrauma immune dysfunction by Kojima, Mitsuaki, Costantini, Todd W, Eliceiri, Brian P, Chan, Theresa W, Baird, Andrew, Coimbra, Raul

“…Exosomes are extracellular vesicles that act as endogenous mediators of the immune response. We have previously shown that exosomes released into mesenteric…”
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Enteric glia cells are critical to limiting the intestinal inflammatory response after injury by Langness, Simone, Kojima, Mitsuaki, Coimbra, Raul, Eliceiri, Brian P, Costantini, Todd W

“…Vagal nerve stimulation (VNS) has been shown to limit intestinal inflammation following injury; however, a direct connection between vagal terminals and…”
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Association between the plasma-to-red blood cell ratio and survival in geriatric and non-geriatric trauma patients undergoing massive transfusion: a retrospective cohort study by Kojima, Mitsuaki, Endo, Akira, Shiraishi, Atsushi, Shoko, Tomohisa, Otomo, Yasuhiro, Coimbra, Raul

“…The benefits of a high plasma-to-red blood cell (RBC) ratio on the survival of injured patients who receive massive transfusions remain unclear, especially in…”
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Physician-led prehospital management is associated with reduced mortality in severe blunt trauma patients: a retrospective analysis of the Japanese nationwide trauma registry by Endo, Akira, Kojima, Mitsuaki, Uchiyama, Saya, Shiraishi, Atsushi, Otomo, Yasuhiro

“…Although the results of previous studies suggested the effectiveness of physician-led prehospital trauma management, it has been uncertain because of the…”
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The role of mesenteric lymph exosomal lipid mediators following intestinal ischemia-reperfusion injury on activation of inflammation by Senda, Atsushi, Morishita, Koji, Kojima, Mitsuaki, Doki, Sanae, Taylor, Beth, Yagi, Masayuki, Watanabe, Arisa, Kobayashi, Tetsuyuki, Aiboshi, Junichi, Coimbra, Raul, Otomo, Yasuhiro

“…Intestinal ischemia caused by hemorrhagic shock is known to induce systemic inflammatory responses. Previous studies have shown that mesenteric lymph (ML)…”
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Vagus nerve stimulation modulates arachidonic acid production in the mesenteric lymph following intestinal ischemia-reperfusion injury by Nakatsutsumi, Keita, Morishita, Koji, Yagi, Masayuki, Doki, Sanae, Watanabe, Arisa, Ikegami, Nahoko, Kobayashi, Testuyuki, Kojima, Mitsuaki, Senda, Atsushi, Yamamoto, Kouhei, Aiboshi, Junichi, Coimbra, Raul, Otomo, Yasuhiro

“…BACKGROUND Inflammatory lipid mediators in mesenteric lymph (ML), including arachidonic acid (AA), are considered to play an important role in the pathogenesis…”
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Electrical stimulation of the vagus nerve improves intestinal blood flow after trauma and hemorrhagic shock by Yagi, Masayuki, Morishita, Koji, Ueno, Akinori, Nakamura, Hajime, Akabori, Hiroya, Senda, Atsushi, Kojima, Mitsuaki, Aiboshi, Junichi, Costantini, Todd, Coimbra, Raul, Otomo, Yasuhiro

“…Gut damage after trauma/hemorrhagic shock contributes to multiple organ dysfunction syndrome. Electrical vagal nerve stimulation is known to prevent gut damage…”
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Extracorporeal cardiopulmonary resuscitation in hypothermic cardiac arrest: A secondary analysis of multicenter extracorporeal cardiopulmonary resuscitation registry data in Japan by Tanizawa, Shu, Kojima, Mitsuaki, Shoko, Tomohisa, Inoue, Akihiko, Hifumi, Toru, Sakamoto, Tetsuya, Kuroda, Yasuhiro

“…Extracorporeal cardiopulmonary resuscitation (ECPR) is used to resuscitate patients with cardiac arrest; however, its effect in treating hypothermic cardiac…”
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Association between body mass index and clinical outcomes in patients with out-of-hospital cardiac arrest undergoing extracorporeal cardiopulmonary resuscitation: A multicenter observational study by Kojima, Mitsuaki, Mochida, Yuzuru, Shoko, Tomohisa, Inoue, Akihiko, Hifumi, Toru, Sakamoto, Tetsuya, Kuroda, Yasuhiro

“…[Display omitted] We examined the association between body mass index (BMI) and outcomes in patients with out-of-hospital cardiac arrest (OHCA) undergoing…”
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Renal arteriovenous malformation treated using glue embolization under inflow and outflow control by balloon occlusion by Suzuki, Tensei, Yamaguchi, Hidenori, Kojima, Mitsuaki, Kariyasu, Toshiya, Nakamoto, Raira, Nishikawa, Makiko, Machida, Haruhiko, Shoko, Tomohisa

“…A 45-year-old female presented with gross hematuria. Right renal arteriovenous malformation on abdominal contrast-enhanced computed tomography necessitated…”
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A case of blindness caused by Lemierre's syndrome by Suzuki, Tensei, Kojima, Mitsuaki, Nakamoto, Raira, Kuriyama, Keiichi, Tanizawa, Shu, Mochida, Yuzuru, Asakura, Yuri, Shibano, Ayaka, Shoko, Tomohisa

“…Key Clinical Message We describe a patient who lost her vision because of Lemierre's syndrome. Ophthalmologic complications of Lemierre's syndrome are rare,…”
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Life‐saving case of cardiopulmonary arrest by secondary aortoenteric fistula formed in the anastomotic site between the inferior mesenteric artery and aortic graft by Yagi, Masayuki, Aiboshi, Junichi, Kojima, Mitsuaki, Yoshikawa, Shunsuke, Morishita, Koji, Kaji, Masahito, Otomo, Yasuhiro

“…Background Secondary aortoenteric fistula is a fatal cause of gastrointestinal bleeding after aortic reconstructive surgery with a prosthesis. In most cases,…”
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Optimal target blood pressure in elderly with septic shock (OPTPRESS) trial: study protocol for a randomized controlled trial by Endo, Akira, Yamakawa, Kazuma, Tagami, Takashi, Umemura, Yutaka, Takahashi, Kyosuke, Nagasawa, Hiroki, Araki, Yuichi, Kojima, Mitsuaki, Sera, Toshiki, Yagi, Masayuki, Yamamoto, Ryo, Takahashi, Jiro, Nakane, Masaki, Takeda, Chikashi, Narita, Chihiro, Kazuma, Satoshi, Okura, Hiroko, Takahashi, Hiroyuki, Wada, Takeshi, Tahara, Shu, Matsuoka, Ayaka, Masaki, Todani, Shiraishi, Atsushi, Shimoyama, Keiichiro, Yokokawa, Yuta, Nakamura, Rintaro, Sageshima, Hisako, Yanagida, Yuichiro, Takahashi, Kunihiko, Otomo, Yasuhiro

“…Abstract Background Hemodynamic stabilization is a core component in the resuscitation of septic shock. However, the optimal target blood pressure remains…”
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Discrete roles of intracellular phospholipases A2 in human neutrophil cytotoxicity by Mikami, Saori, Aiboshi, Junichi, Kobayashi, Tetsuyuki, Kojima, Mitsuaki, Morishita, Koji, Otomo, Yasuhiro

“…The role of calcium-independent phospholipase A2 (iPLA2), a component of the three major PLA2 families, in acute/chronic inflammatory processes remains…”
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Age-Related Characteristics and Outcomes for Patients With Severe Trauma: Analysis of Japan’s Nationwide Trauma Registry by Kojima, Mitsuaki, Endo, Akira, Shiraishi, Atsushi, Otomo, Yasuhiro

“…Although geriatric trauma patients are becoming more common, few large-scale analyses have comprehensively evaluated geriatric-specific characteristics in…”
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Does frailty impact failure-to-rescue in geriatric trauma patients? by Kojima, Mitsuaki, Morishita, Koji, Shoko, Tomohisa, Zakhary, Bishoy, Costantini, Todd, Haines, Laura, Coimbra, Raul

“…Failure-to-rescue (FTR), defined as death following a major complication, is a metric of trauma quality. The impact of patient frailty on FTR has not been…”
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