Search Results - "Koizumi, Shinichi"

Prostaglandin E Receptor 4 Antagonist in Cancer Immunotherapy: Mechanisms of Action by Take, Yukinori, Koizumi, Shinichi, Nagahisa, Atsushi

“…A highly expressed prostaglandin E (PGE ) in tumor tissues suppresses antitumor immunity in the tumor microenvironment (TME) and causes tumor immune evasion…”
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Differences in survival‐promoting effects and intracellular signaling properties of BDNF and IGF‐1 in cultured cerebral cortical neurons by Yamada, Masashi, Tanabe, Keiko, Wada, Kazuyo, Shimoke, Koji, Ishikawa, Yasuyuki, Ikeuchi, Toshihiko, Koizumi, Shinichi, Hatanaka, Hiroshi

“…Brain‐derived neurotrophic factor (BDNF) and insulin‐like growth factor‐1 (IGF‐1) act on various neurons of the CNS as neurotrophic factors promoting neuronal…”
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Mutation is the Main Driving Force in the Diversification of the Vibrio splendidus Clade by Sawabe, Tomoo, Koizumi, Shinichi, Fukui, Youhei, Nakagawa, Satoshi, Ivanova, Elena P., Kita-Tsukamoto, Kumiko, Kogure, Kazuhiro, Thompson, Fabiano L.

“…The Vibrio splendidus clade is the biggest in Vibrionales composed of 11 described species (25). Diversification of these species may have occurred 260 million…”
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Discrimination between phosphotyrosine-mediated signaling properties of conventional and neuronal Shc adapter molecules by NAKAMURA, Takeshi, KOMIYA, Misako, GOTOH, Noriko, KOIZUMI, Shinichi, SHIBUYA, Masabumi, MORI, Nozomu

“…The phosphotyrosine (pTyr) adapter Shc/ShcA is a major connector in various tyrosine kinase signalings following a variety of stimulation such as growth…”
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Acetylcholine Triggers L-Glutamate Exocytosis via Nicotinic Receptors and Inhibits Melatonin Synthesis in Rat Pinealocytes by Yamada, Hiroshi, Ogura, Akihiko, Koizumi, Shinichi, Yamaguchi, Akihito, Moriyama, Yoshinori

“…Rat pinealocytes, melatonin-secreting endocrine cells, contain peripheral glutaminergic systems. L-Glutamate is a negative regulator of melatonin synthesis…”
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Nerve Growth Factor Enhances Neurotransmitter Release from PC12 Cells by Increasing Ca2+-Responsible Secretory Vesicles through the Activation of Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase by Amino, Shinya, Itakura, Makoto, Ohnishi, Hiroshi, Tsujimura, Jun, Koizumi, Shinichi, Takei, Nobuyuki, Takahashi, Masami

“…Neurotrophins play important roles in the differentiation and survival of neurons during development, and in the regulation of synaptic transmission in adult…”
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A Neuroprotective Compound, Aurin Tricarboxylic Acid, Stimulates the Tyrosine Phosphorylation Cascade in PC12 Cells by Okada, Noriko, Koizumi, Shinichi

“…Aurin tricarboxylic acid (ATA), a general nuclease inhibitor, was reported to prevent PC12 cells from cell death caused by serum starvation(1). In our study,…”
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Midkine, a Heparin-Binding Growth/Differentiation Factor, Exhibits Nerve Cell Adhesion and Guidance Activity for Neurite Outgrowth In Vitro by Kaneda, Norio, Talukder, Amjad H., Nishiyama, Hiroko, Koizumi, Shinichi, Muramatsu, Takashi

“…By means of a baculovirus expression system, a large amount of mouse midkine (MK) was produced. The protein was purified to homogeneity by heparin-Sepharose…”
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Induction of a Distinct Morphology and Signal Transduction in TrkB/PC12 Cells by Nerve Growth Factor and Brain‐Derived Neurotrophic Factor by Iwasaki, Yasuno, Ishikawa, Mitsue, Okada, Noriko, Koizumi, Shinichi

“…: A clonal cell line stably expressing trkB (TrkB/PC12) was established from rat pheochromocytoma PC12 cells. Brain‐derived neurotrophic factor (BDNF), as well…”
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Tyrosine Phosphorylation of ErbB4 Is Stimulated by Aurintricarboxylic Acid in Human Neuroblastoma SH-SY5Y Cells by Okada, Noriko, Koizumi, Shinichi

“…Aurintricarboxylic acid (ATA) has been reported to protect PC12 cells and cultured neuronal cells from serum starvation-induced cell death, and hippocampal…”
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Analysis of Tyrosine Phosphorylation-Dependent Protein-Protein Interactions in TrkB-Mediated Intracellular Signaling Using Modified Yeast Two-Hybrid System by Yamada, Masashi, Suzuki, Kenji, Mizutani, Masaharu, Asada, Akiko, Matozaki, Takashi, Ikeuchi, Toshihiko, Koizumi, Shinichi, Hatanaka, Hiroshi

“…Activated receptor tyrosine kinases induce a large number of tyrosine phosphorylation-dependent protein-protein interactions through which they mediate their…”
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Nerve growth factor induces resistance of PC12 cells to nitric oxide cytotoxicity by Wada, Kazuyo, Okada, Noriko, Yamamura, Takaki, Koizumi, Shinichi

“…Nitric oxide (NO) donors, sodium nitroprusside and NOC 7, caused pheochromocytoma (PC12) cell death in a concentration and time-dependent manner. This…”
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Effects of imagery ability and speech anxiety on imagery vividness of imaginary of speech scene by Koizumi, S

“…Effects of imagery ability and speech anxiety on imagery vividness of imaginary of speech scene were examined. Subjects were divided into four groups in terms…”
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Lysophospholipase I identified as a ghrelin deacylation enzyme in rat stomach by Shanado, Yuka, Kometani, Motohiko, Uchiyama, Hidefumi, Koizumi, Shinichi, Teno, Naoki

“…Ghrelin, discovered in rat stomach as an endogenous growth hormone secretagogue, is octanoylated at the Ser3 residue. Since this octanoylation is essential for…”
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Intracluster Reactions of (CS2) n - and (OCS) n - Induced by Surface Impact by Koizumi, Shin'ichi, Yasumatsu, Hisato, Otani, Shigeki, Kondow, Tamotsu

“…We investigated an intracluster reaction induced by impact of (CS2) n - (n = 1−8) onto silicon and (La0.7Ce0.3)B6 surfaces at collision energies of 100−2000 eV…”
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Discovery of Orally Bioavailable Cathepsin S Inhibitors for the Reversal of Neuropathic Pain by Irie, Osamu, Kosaka, Takatoshi, Ehara, Takeru, Yokokawa, Fumiaki, Kanazawa, Takanori, Hirao, Hajime, Iwasaki, Astuko, Sakaki, Junichi, Teno, Naoki, Hitomi, Yuko, Iwasaki, Genji, Fukaya, Hiroaki, Nonomura, Kazuhiko, Tanabe, Keiko, Koizumi, Shinichi, Uchiyama, Noriko, Bevan, Stuart J, Malcangio, Marzia, Gentry, Clive, Fox, Alyson J, Yaqoob, Mohammed, Culshaw, Andrew J, Hallett, Allan

“…Cathepsin S inhibitors are well-known to be an attractive target as immunological therapeutic agents. Recently, our gene expression analysis identified that…”
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Energy Redistribution in I2 -(CO2) n Collision on Silicon Surface by Yasumatsu, Hisato, Koizumi, Shin'ichi, Terasaki, Akira, Kondow, Tamotsu

“…A process of energy redistribution in the collision of I2 -(CO2) n (n = 1−50) with a silicon surface was investigated by measuring the surface-parallel…”
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Association of the Src Family Tyrosine Kinase Fyn with TrkB by Iwasaki, Yasuno, Gay, Brigitte, Wada, Kazuyo, Koizumi, Shinichi

“…: Fyn tyrosine kinase, a member of the Src family, was recently reported to be present in neurons and glia cells. We investigated whether Fyn is involved in…”
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Nerve growth factor enhances neurotransmitter release from PC12 cells by increasing Ca(2+)-responsible secretory vesicles through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase by Amino, Shinya, Itakura, Makoto, Ohnishi, Hiroshi, Tsujimura, Jun, Koizumi, Shinichi, Takei, Nobuyuki, Takahashi, Masami

“…Neurotrophins play important roles in the differentiation and survival of neurons during development, and in the regulation of synaptic transmission in adult…”
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Inhibition of phenylalanine hydroxylase, a pterin-requiring monooxygenase, by oudenone and its derivatives by Koizumi, S, Nagatsu, T, Iinuma, H, Ohno, M, Takeuchi, T, Umezawa, H

“…Phenylalanine hydroxylase was shown to be inhibited by oudenone and its derivatives in vitro. At a concentration of 2.3 x 10(-3) M, oudenone inhibited…”
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